CAR-T-CELL THERAPY
    10.
    发明申请

    公开(公告)号:US20220401476A1

    公开(公告)日:2022-12-22

    申请号:US17442115

    申请日:2021-07-23

    申请人: AB2 BIO SA

    IPC分类号: A61K35/17 A61P35/00 C07K16/24

    摘要: The present invention provides compounds and compositions for use in the treatment of cancer as part of a Chimeric Antigen Receptor T-cell (CAR-T) therapy. In particular, the present invention discloses IL-18 binding molecules such as, for example, the IL-18 binding protein (IL-18BP) for use in Chimeric Antigen Receptor T-cell (CAR-T) therapy as a modulator to avoid or minimize side effects.