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公开(公告)号:US11926663B2
公开(公告)日:2024-03-12
申请号:US17195518
申请日:2021-03-08
申请人: AB2 BIO SA
发明人: Greg Del Val , Eduardo Schiffrin
CPC分类号: C07K16/244 , A61K38/1709 , G01N33/6869 , A61K2039/505 , A61K2039/545 , C07K2317/30 , C07K2317/76 , C07K2317/92 , G01N2333/54
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.
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公开(公告)号:US20230250164A1
公开(公告)日:2023-08-10
申请号:US18054936
申请日:2022-11-14
申请人: AB2 Bio SA
发明人: Andrea Pfeifer , Greg Del Val
IPC分类号: C07K16/24 , C07K14/715 , C07K14/54 , A61K38/00 , G01N33/564 , G01N33/68
CPC分类号: C07K16/244 , C07K14/7155 , C07K14/54 , A61K38/00 , G01N33/564 , G01N33/6869 , C07K14/705
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the indications.
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公开(公告)号:US11530263B2
公开(公告)日:2022-12-20
申请号:US16883735
申请日:2020-05-26
申请人: AB2 BIO SA
发明人: Andrea Pfeifer , Greg Del Val
IPC分类号: C07K14/54 , C07K14/715 , A61K38/00 , C07K16/24 , G01N33/564 , G01N33/68 , C07K14/705 , A61K39/00
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the indications.
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公开(公告)号:US10858426B2
公开(公告)日:2020-12-08
申请号:US14916917
申请日:2014-09-05
申请人: AB2 BIO SA
发明人: Andrea Pfeifer , Greg Del Val
IPC分类号: C07K16/24 , G01N33/68 , C07K14/54 , C07K14/715 , G01N33/564 , C07K14/705 , A61K39/00
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the indications.
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公开(公告)号:US11820817B2
公开(公告)日:2023-11-21
申请号:US16883906
申请日:2020-05-26
申请人: AB2 BIO SA
发明人: Greg Del Val , Eduardo Schiffrin
CPC分类号: C07K16/244 , A61K38/1709 , G01N33/6869 , A61K2039/505 , A61K2039/545 , C07K2317/30 , C07K2317/76 , C07K2317/92 , G01N2333/54
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.
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公开(公告)号:US20230173021A1
公开(公告)日:2023-06-08
申请号:US17998021
申请日:2021-05-06
申请人: AB2 Bio SA
发明人: Eduardo Schiffrin
CPC分类号: A61K38/1709 , A61P11/00 , A61P31/14 , A61P29/00 , A61K45/06
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated respiratory diseases and disorders, particularly means and methods for treating virus-induced IL-18 associated respiratory diseases. In particular, the present invention discloses IL-18 inhibitors such as, for example, the IL-18 binding protein (IL-18BP) for use in the treatment of Interleukin 18 (IL-18)-associated respiratory diseases and disorders such as virus-induced ARDS.
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公开(公告)号:US10882905B2
公开(公告)日:2021-01-05
申请号:US15555446
申请日:2016-03-03
申请人: AB2 BIO SA
发明人: Greg Del Val , Eduardo Schiffrin
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders, in particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.
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公开(公告)号:US20240190952A1
公开(公告)日:2024-06-13
申请号:US18436802
申请日:2024-02-08
申请人: AB2 BIO SA
发明人: Greg Del Val , Eduardo Schiffrin
CPC分类号: C07K16/244 , A61K38/1709 , G01N33/6869 , A61K2039/505 , A61K2039/545 , C07K2317/30 , C07K2317/76 , C07K2317/92 , G01N2333/54
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.
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公开(公告)号:US20200377586A1
公开(公告)日:2020-12-03
申请号:US16883906
申请日:2020-05-26
申请人: AB2 BIO SA
发明人: Greg DEL VAL , Eduardo SCHIFFRIN
摘要: The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.
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公开(公告)号:US20220401476A1
公开(公告)日:2022-12-22
申请号:US17442115
申请日:2021-07-23
申请人: AB2 BIO SA
发明人: Eduardo SCHIFFRIN , Michael SOLDAN
摘要: The present invention provides compounds and compositions for use in the treatment of cancer as part of a Chimeric Antigen Receptor T-cell (CAR-T) therapy. In particular, the present invention discloses IL-18 binding molecules such as, for example, the IL-18 binding protein (IL-18BP) for use in Chimeric Antigen Receptor T-cell (CAR-T) therapy as a modulator to avoid or minimize side effects.
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