公开(公告)号：US4477460A

公开(公告)日：1984-10-16

申请号：US435195

申请日：1982-10-19

Applicant: L. David Waterbury ,  A. Peter Roszkowski

Inventor： L. David Waterbury ,  A. Peter Roszkowski

IPC: A61K31/425

CPC classification number: A61K31/425 ,  Y10S514/912

Abstract: This invention concerns the novel use of certain known thiazoles, particularly acylaminothiazoles and thiazolecarboxamides, as intraocular pressure lowering agents. When administered topically to the eye with increased intraocular pressure the compounds are effective in decreasing intraocular pressure, in preventing development of acute or chronic ocular hypertension including glaucoma, in inhibiting the further deterioration of the eye due to intraocular hypertension, or in relieving the symptoms of already existing ophthalmic disease.

Abstract translation: 本发明涉及某些已知的噻唑，特别是酰氨基噻唑和噻唑甲酰胺作为眼压降低剂的新用途。 当眼内压升高时，化合物有效降低眼内压，防止急性或慢性高眼压症（包括青光眼）的发展，抑制由于眼内高血压引起的眼睛的进一步恶化，或缓解眼睛的症状 已经存在眼科疾病。