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公开(公告)号：US11096760B2
公开(公告)日：2021-08-24
申请号：US17028593
申请日：2020-09-22
申请人： Gynesonics, Inc.
发明人： Michael Munrow , Jordan Bajor , Malcolm G. Munro
摘要： Needles are deployed in tissue under direct ultrasonic or other imaging. To aid in deploying the needle, a visual needle guide is projected on to the image prior to needle deployment. Once the needle guide is properly aligned, the needle can be deployed. After needle deployment, a safety boundary and treatment region are projected on to the screen. After confirming that the safety boundary and treatment regions are sufficient, the patient can be treated using the needle.
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公开(公告)号：US11057714B2
公开(公告)日：2021-07-06
申请号：US16260684
申请日：2019-01-29
申请人： EarLens Corporation
发明人： Sunil Puria , Micha Rosen , Jonathan P. Fay , Paul Rucker , James Stone
摘要： A device to transmit an audio signal to a user comprises a transducer and a support. The support is configured for placement on the eardrum to drive the eardrum. The transducer is coupled to the support at a first location to decrease occlusion and a second location to drive the eardrum. The transducer may comprise one or more of an electromagnetic balanced armature transducer, a piezoelectric transducer, a magnetostrictive transducer, a photostrictive transducer, or a coil and magnet. The device may find use with open canal hearing aids.
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公开(公告)号：US11045121B2
公开(公告)日：2021-06-29
申请号：US16253678
申请日：2019-01-22
发明人： Rinat Esenaliev , Donald S. Prough , Yuriy Petrov , Irene Petrov , George Saade , Gayle L. Olson , Tommy G. Cooper
IPC分类号： A61B5/1455 , A61B5/145 , A61B5/00 , A61B5/1464 , A61B5/1459
摘要： Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.
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公开(公告)号：US10967050B2
公开(公告)日：2021-04-06
申请号：US16390871
申请日：2019-04-22
发明人： Mir Imran
IPC分类号： A61K38/22 , A61M25/10 , A61M5/00 , A61K38/26 , A61K9/48 , A61K31/155 , A61K9/00 , A61M31/00 , A61K38/28
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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公开(公告)号：US10953077B2
公开(公告)日：2021-03-23
申请号：US16391087
申请日：2019-04-22
发明人： Mir Imran
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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公开(公告)号：US10926089B2
公开(公告)日：2021-02-23
申请号：US16723749
申请日：2019-12-20
发明人： Badri Amurthur
摘要： The present methods and apparatus can provide improved efficacy with improved tolerance. The methods and apparatus can be configured to alter the stimulus, which can decrease neural adaptation of the subject and provide an improved response. The acoustic stimulus can be delivered as a tone, which can make the stimulus more acceptable to the subject receiving the stimulus. The stimulus may comprise a varying stimulus in order to decrease neural adaptation to the stimulus. The stimulus can be varied by varying one or more of a duty cycle, a frequency, or a shape of the waveform. The waveform may comprise a plurality of individual pulses, in which the waveform varies among pulses of the plurality. Acoustic stimulation can be combined with electrical stimulation. The device may comprise a plurality of sensors to determine the response of the subject.
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公开(公告)号：US10888240B2
公开(公告)日：2021-01-12
申请号：US15783346
申请日：2017-10-13
申请人： CeriBell, Inc.
发明人： Josef Parvizi , Xingjuan Chao , Bradley G. Bachelder , Raymond Woo , Mathew A. Herron , Vahid Saadat , Alexander M. Grant , Jianchun Yi
IPC分类号： A61B5/0478 , A61B5/0402 , A61B5/00
摘要： An electrode carrier system includes one or more electrode assemblies having an electrode body. One or more tubular members extend from the electrode body and define a lumen terminating in a distal opening. The electrode assemblies carry a reservoir containing a conductive fluid or gel. The reservoir is in fluid communication with the lumens in the tubular members, and the electrode assemblies are typically supported on a backing which may optionally be configured as a headband. Systems are for tracking patient movement may be used in combination with the electrode carrier system.
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公开(公告)号：US10752681B2
公开(公告)日：2020-08-25
申请号：US15220249
申请日：2016-07-26
发明人： Mir Imran
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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公开(公告)号：US10689460B2
公开(公告)日：2020-06-23
申请号：US15260260
申请日：2016-09-08
申请人： Incube Labs, LLC
发明人： Mir Imran , Radhika Korupolu , Elaine To , Joel Harris , Mir Hashim
摘要： Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
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公开(公告)号：US10603475B2
公开(公告)日：2020-03-31
申请号：US16275586
申请日：2019-02-14
发明人： Mir Imran
IPC分类号： A61M31/00 , A61K31/155 , A61K38/26 , A61K38/28 , A61K9/48 , A61M5/20 , A61K38/27 , A61M5/168 , A61K38/22 , A61K45/06 , A61K38/29 , A61K9/00 , A61K38/17 , A61M5/172 , A61M5/142 , A61M5/14
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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