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公开(公告)号：US07271146B2
公开(公告)日：2007-09-18
申请号：US10682937
申请日：2003-10-14
申请人： Sabina Glozman
发明人： Sabina Glozman
CPC分类号： A61K31/4439 , A61K38/2207 , A61K2300/00
摘要： The present invention relates to methods for treating pathological conditions associated with Helicobacter sp infections, specifically H. pylori infection. The present invention further relates to methods for treating pathologies characterized by excess gastric acid secretion. The methods of the present invention comprise oral administration of pentagastrin effective locally in the stomach in conjunction with a gastric proton pump inhibitor. It is disclosed herein for the first time that PG administered orally exerts a local effect in the stomach and may be used in combination with a PPI for treating pathological conditions characterized by excess gastric acid secretion and in pathological conditions associated with Helicobacter sp infections.
摘要翻译： 本发明涉及用于治疗与幽门螺杆菌感染，特别是幽门螺杆菌感染相关的病理状况的方法。 本发明还涉及以过量胃酸分泌为特征的治疗病态的方法。 本发明的方法包括与胃质子泵抑制剂联合在胃部局部施用五加胃泌素的口服给药。 本文首次公开了口服给药的PG在胃中发挥局部作用，并且可以与PPI组合使用，用于治疗特征在于过量胃酸分泌的病理状况以及与幽门螺杆菌感染相关的病理状况。
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公开(公告)号：US09132082B2
公开(公告)日：2015-09-15
申请号：US12991746
申请日：2009-05-14
申请人： Aleksey Kostadinov , Tal Atarot , Michael Naveh
发明人： Aleksey Kostadinov , Tal Atarot , Michael Naveh
IPC分类号： A61K31/19 , A61K31/4439 , A61K9/16 , A61P1/04 , A61K9/00 , A61K9/20 , A61K9/48 , A61K9/50 , A61K31/191 , A61K45/06 , A61K47/12
CPC分类号： A61K9/0004 , A61K9/0019 , A61K9/2081 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/191 , A61K31/4439 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+ ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
摘要翻译： 本发明涉及包含作为胃酸分泌抑制剂的不可逆胃H + / K + ATP酶质子泵抑制剂（PPI）和作为胃内腔壁细胞激活剂的一种或多种小羧酸分子的新型口服组合物。 意外地，本发明的组合物能够增强胃中PPI的抗酸活性。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。
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公开(公告)号：US07803817B2
公开(公告)日：2010-09-28
申请号：US11191688
申请日：2005-07-27
申请人： Aleksey Kostadinov , Ayelet David , Sabina Glozman
发明人： Aleksey Kostadinov , Ayelet David , Sabina Glozman
IPC分类号： A61K31/4439 , A61K31/194
CPC分类号： A61K31/19 , A61K9/2081 , A61K31/4439 , A61K47/12 , A61K2300/00
摘要： The present invention is related to oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and succinc acid as a parietal cell activator in the gastric lumen. The compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
摘要翻译： 本发明涉及含有作为胃酸分泌抑制剂的不可逆胃H + / K + -ATP酶质子泵抑制剂（PPI）和胃肠腔中作为壁细胞活化剂的琥珀酸的口服组合物。 本发明的组合物能够增强胃中PPI的抗酸活性。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。
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公开(公告)号：US20080248109A1
公开(公告)日：2008-10-09
申请号：US12120599
申请日：2008-05-14
申请人： Aleksey Kostadinov , David Ayelet , Sabina Glozman , Tal Atarot
发明人： Aleksey Kostadinov , David Ayelet , Sabina Glozman , Tal Atarot
IPC分类号： A61K9/48 , A61K31/191 , A61P1/04
CPC分类号： A61K9/0004 , A61K9/0019 , A61K9/2081 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/191 , A61K31/4439 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
摘要翻译： 本发明涉及新的口服组合物，其包含作为胃酸分泌抑制剂的不可逆的胃H + / 小羧酸分子作为胃腔中的壁细胞激活剂。 意外地，本发明的组合物能够增强胃中PPI的抗酸活性。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。
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公开(公告)号：US09278080B2
公开(公告)日：2016-03-08
申请号：US12768375
申请日：2010-04-27
申请人： Aleksey Kostadinov , Ayelet David , Sabina Glozman
发明人： Aleksey Kostadinov , Ayelet David , Sabina Glozman
IPC分类号： A61K31/19 , A61K9/20 , A61K31/4439 , A61K47/12
CPC分类号： A61K31/19 , A61K9/2081 , A61K31/4439 , A61K47/12 , A61K2300/00
摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
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公开(公告)号：US09370481B2
公开(公告)日：2016-06-21
申请号：US13089535
申请日：2011-04-19
申请人： Aleksey Kostadinov , David Ayelet , Sabina Glozman , Tal Atarot
发明人： Aleksey Kostadinov , David Ayelet , Sabina Glozman , Tal Atarot
IPC分类号： A61K9/48 , A61K9/00 , A61P1/04 , A61K31/4439 , A61K31/19 , A61K31/194 , A61K31/215 , A61K31/225 , A61K31/7048 , A61K31/197 , A61K31/166 , A61K31/454 , A61K31/4468 , A61K31/4045 , A61K38/31 , A61K9/20 , A61K9/50 , A61K31/191 , A61K45/06 , A61K47/12
CPC分类号： A61K9/0004 , A61K9/0019 , A61K9/2081 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/191 , A61K31/4439 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
摘要翻译： 本发明涉及包含作为胃酸分泌抑制剂的不可逆胃H + / K + -ATP酶质子泵抑制剂（PPI）和作为胃内腔壁细胞活化剂的一种或多种小羧酸分子的新型口服组合物。 意外地，本发明的组合物能够增强胃中PPI的抗酸活性。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。
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7.发明授权公开(公告)号：US09233092B2
公开(公告)日：2016-01-12
申请号：US12309563
申请日：2007-07-19
申请人： Michael Marash , Aleksey Kostadinov , Tal Atarot
发明人： Michael Marash , Aleksey Kostadinov , Tal Atarot
IPC分类号： A61K31/22 , A61K31/225 , A61K31/4439 , A61K9/14 , A61K31/19 , A61K31/194 , A61K31/44 , A61K31/522 , A61K9/16 , A61K9/20 , A61K9/24 , A61K9/26 , A61K9/28 , A61K9/48 , A61K45/00 , A61K45/06 , A61P1/04 , A61P31/04 , A61P43/00 , A61K33/10 , A61K36/534 , A61K9/50
CPC分类号： A61K31/22 , A61K9/2081 , A61K9/2086 , A61K9/5084 , A61K31/19 , A61K31/225 , A61K31/4439 , A61K31/522 , A61K33/10 , A61K36/534 , A61K45/00 , A61K45/06 , A61K2300/00
摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more aliphatic carboxylic acid derivative molecules which activate parietal cells, wherein the derivatives possess delayed or sustained enhancement effect on the PPI activity compared to the non-derivatized acid molecules. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
摘要翻译： 本发明涉及包含不可逆胃H + / K + -ATP酶质子泵抑制剂（PPI）作为胃酸分泌抑制剂和一种或多种活化壁细胞的脂肪族羧酸衍生物分子的新型口服组合物，其中衍生物具有延迟或 与未衍生的酸分子相比，PPI活性持续增强作用。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。
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公开(公告)号：US07981908B2
公开(公告)日：2011-07-19
申请号：US12120599
申请日：2008-05-14
申请人： Aleksey Kostadinov , David Ayelet , Sabina Glozman , Tal Atarot
发明人： Aleksey Kostadinov , David Ayelet , Sabina Glozman , Tal Atarot
IPC分类号： A61K31/4439 , A61K31/194
CPC分类号： A61K9/0004 , A61K9/0019 , A61K9/2081 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/191 , A61K31/4439 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
摘要翻译： 本发明涉及包含作为胃酸分泌抑制剂的不可逆胃H + / K + -ATP酶质子泵抑制剂（PPI）和作为胃内腔壁细胞活化剂的一种或多种小羧酸分子的新型口服组合物。 意外地，本发明的组合物能够增强胃中PPI的抗酸活性。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。
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