公开(公告)号：US07489209B2

公开(公告)日：2009-02-10

申请号：US11409224

申请日：2006-04-20

申请人： Oleg Mosesov

发明人： Oleg Mosesov

IPC分类号： H03B5/32 ,  H03B5/30 ,  H03B5/36 ,  H03L7/099 ,  H03K3/354

CPC分类号： H03B5/06 ,  H03B5/32

摘要： An oscillator for use within an implantable medical device is provided. The oscillator includes a resonator and a first switch coupled to a first resistive network. The first resistive network provides a first electrical path through the first switch and a second electrical path not going through the switch. The oscillator additionally includes a second switch coupled to a second resistive network. The second resistive network provides a third electrical path through the second switch and a fourth electrical path not going through the switch. Furthermore, the oscillator includes a transistor, the base terminal coupled with the first resistive network and the resonator and the emitter terminal coupled to the fourth resistor. The second electrical path with the first switch opened has a substantially higher resistance than the first electrical path when the first switch is closed. In addition, the fourth electrical path with the second switch opened has a substantially higher resistance than the third electrical path when the second switch is closed.

摘要翻译： 提供了一种用于可植入医疗装置内的振荡器。 振荡器包括耦合到第一电阻网络的谐振器和第一开关。 第一电阻网络提供穿过第一开关的第一电路径和不经过开关的第二电路径。 振荡器还包括耦合到第二电阻网络的第二开关。 第二电阻网络提供穿过第二开关的第三电路径和不经过开关的第四电路径。 此外，振荡器包括晶体管，与第一电阻网络耦合的基极端子和耦合到第四电阻器的谐振器和发射极端子。 当第一开关闭合时，第一开关断开的第二电路具有比第一电路大得多的电阻。 此外，当第二开关闭合时，第二开关打开的第四电路具有比第三电路大得多的电阻。

公开(公告)号：US20060253160A1

公开(公告)日：2006-11-09

申请号：US11485747

申请日：2006-07-12

申请人： David Benditt ,  Brian Brockway ,  Richard Wilson

发明人： David Benditt ,  Brian Brockway ,  Richard Wilson

IPC分类号： A61N1/00 ,  A61B5/02 ,  A61B5/04

CPC分类号： A61M5/1723 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/3702

摘要： Devices and methods for detecting inadequate tissue perfusion by measuring a parameter other than heart rate such as vascular blood pressure, intracardiac blood pressure, vascular blood flow or tissue perfusion, in addition to or as a substitute for heart rate. Such devices and methods improve the accuracy of determining when and to what degree therapy should be administered to treat inadequate tissue perfusion, such as pre-syncope, syncope, or orthostatic hypotension, particularly in the absence of abnormal cardiac function.

公开(公告)号：US20060178617A1

公开(公告)日：2006-08-10

申请号：US11402158

申请日：2006-04-10

申请人： H. Adams ,  Brian Brockway ,  Perry Mills

发明人： H. Adams ,  Brian Brockway ,  Perry Mills

IPC分类号： A61M31/00

CPC分类号： A61B5/0028 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/0402 ,  A61B5/145 ,  A61B5/14532 ,  A61M39/0208 ,  A61M2039/0229 ,  A61M2205/3368 ,  A61M2205/3523 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2230/00 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/50

摘要： A combined vascular access port and physiologic parameter monitoring device. The vascular access port and the monitoring device may be connected by a cooperative geometry. The vascular access port and the monitoring device may be implanted at the same time and in the same anatomical location (e.g., subcutaneous pocket). The monitoring device may include a telemetry unit that transmits physiological measurement data to a local data collection system (e.g., carried by the patient or located in the patient's home), which may re-transmit the data to a remote data collection system (e.g., located at a physician's office or clinic) via a suitable communication link.

摘要翻译： 组合血管通路口和生理参数监测装置。 血管入口和监测装置可以通过协作几何形状连接。 血管通路口和监测装置可以在同一时间和相同的解剖位置植入（例如皮下袋）。 监测装置可以包括遥测单元，该遥测单元将生理测量数据传输到本地数据收集系统（例如，由病人携带或位于患者家中），其可以将数据重新发送到远程数据收集系统（例如， 位于医生办公室或诊所）通过适当的通信链路。

公开(公告)号：US20060094966A1

公开(公告)日：2006-05-04

申请号：US11304452

申请日：2005-12-14

申请人： Brian Brockway ,  Perry Mills ,  Mel Moench

发明人： Brian Brockway ,  Perry Mills ,  Mel Moench

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/0215 ,  A61B5/031 ,  A61M2025/0003

摘要： A device measures pressures in animals and humans and includes a pressure transmission catheter (PTC) filled with a pressure transmitting medium and implantable in an area in having a physiological pressure. A transducer communicates with the pressure transmitting medium to provide a pressure signal representing variations in the physiologic pressure on electrical wires. A connecting catheter carries the electrical wires to signal processing and telemetry circuitry, which transmits a telemetry signal representing the pressure signal to a receiver external to the animal or human. A housing holds the signal processing and telemetry circuitry, but the transducer is remote from the housing. The device is particularly useful in measuring venous pressure, pulmonary pressure, bladder pressure, or intracranial pressure without significant head pressure artifact and with a sufficient dynamic response. One embodiment of the PTC includes a multi-durometer stem.

公开(公告)号：US20050256451A1

公开(公告)日：2005-11-17

申请号：US11190789

申请日：2005-07-26

申请人： H. Adams ,  Brian Brockway ,  Perry Mills

发明人： H. Adams ,  Brian Brockway ,  Perry Mills

IPC分类号： A61K9/22 ,  A61M31/00

CPC分类号： A61M39/0208 ,  A61M5/158 ,  A61M5/16831 ,  A61M2039/0226 ,  A61M2039/0244

摘要： A vascular access port system including means for detecting and indicating the presence or absence of a needle. The detecting and indicating means may be carried in whole or in part by one of or both of the needle and/or the vascular access port. The detecting and indicating means may utilize a conductive needle, a mechanical switch, a magnetic switch, a Hall effect sensor, an electric field, a magnetic field, or an inductor, for example, for detection purposes. The vascular access port system permits the practitioner to confirm that the needle has been correctly inserted into the VAP, and notifies the patient and/or practitioner if the needle has been accidentally withdrawn.

摘要翻译： 一种血管通路系统，包括用于检测和指示针的存在或不存在的装置。 检测和指示装置可以全部或部分地由针和/或血管进入口中的一个或两个承载。 检测和指示装置可以使用导电针，机械开关，磁开关，霍尔效应传感器，电场，磁场或电感器，例如用于检测目的。 血管通路系统允许从业者确认针已被正确地插入到VAP中，并且如果针被意外地取出，则通知患者和/或从业者。

公开(公告)号：US06962580B2

公开(公告)日：2005-11-08

申请号：US10246324

申请日：2002-09-17

申请人： H. Clark Adams ,  Brian P. Brockway ,  Perry A. Mills

发明人： H. Clark Adams ,  Brian P. Brockway ,  Perry A. Mills

IPC分类号： A61K9/22 ,  A61M31/00

CPC分类号： A61M39/0208 ,  A61M5/158 ,  A61M5/16831 ,  A61M2039/0226 ,  A61M2039/0244

摘要： A vascular access port system including circuits for detecting and indicating the presence or absence of a needle. The detecting and indicating circuits may be carried in whole or in part by one of or both of the needle and/or the vascular access port. The detecting and indicating circuits may utilize a conductive needle, a mechanical switch, a magnetic switch, a Hall effect sensor, an electric field, a magnetic field, or an inductor, for example, for detection purposes. The vascular access port system permits the practitioner to confirm that the needle has been correctly inserted into the VAP, and notifies the patient and/or practitioner if the needle has been accidentally withdrawn.

摘要翻译： 一种血管通路系统，包括用于检测和指示针的存在或不存在的电路。 检测和指示电路可以全部或部分地由针和/或血管进入口中的一个或两者承载。 检测和指示电路可以使用导电针，机械开关，磁性开关，霍尔效应传感器，电场，磁场或电感器，例如用于检测目的。 血管通路系统允许从业者确认针已被正确地插入到VAP中，并且如果针被意外地取出，则通知患者和/或从业者。

公开(公告)号：US20050159789A1

公开(公告)日：2005-07-21

申请号：US11079973

申请日：2005-03-14

申请人： Brian Brockway ,  Perry Mills ,  Lynn Zwiers

发明人： Brian Brockway ,  Perry Mills ,  Lynn Zwiers

IPC分类号： A61B5/00 ,  A61B5/0215 ,  A61N1/362

CPC分类号： A61B5/6882 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/0215 ,  A61N1/37205

摘要： An implantable sensor device, such as a pressure monitor, is implanted in the left ventricle (LV), in other heart chambers, or elsewhere, from which it wirelessly communicates pressure information to a remote communication device. The sensor device can be implanted using a placement catheter, an endoscope, or a laparoscope. The device can be secured entirely within the LV or heart wall, such as by using a corkscrew, a helical anchor, a harpoon, a threaded member, a hook, a barb, a fastener, a suture, or a mesh or coating for receiving fibrous tissue growth. The implantable sensor device provides less invasive chronic measurements of left ventricular blood pressure or other physical parameters. The wireless communication techniques include radio-telemetry, inductive coupling, passive transponders, and using the body as a conductor (referred to as “intracorporeal conductive communication” or a “personal area network”). Data from the receiver is downloadable into a computer for analysis or display.

摘要翻译： 诸如压力监测器的植入式传感器装置被植入左心室（LV），其他心室或其他地方，从而将压力信息与之无线地传送到远程通信装置。 可以使用放置导管，内窥镜或腹腔镜植入传感器装置。 该装置可以完全固定在LV或心壁内，例如通过使用开瓶器，螺旋锚，鱼叉，螺纹构件，钩，倒钩，紧固件，缝线或用于接收的网眼或涂层 纤维组织生长。 植入式传感器装置提供对左心室血压或其他物理参数的侵入性较小的慢性测量。 无线通信技术包括无线电遥测，电感耦合，无源应答器，以及使用身体作为导体（称为“体内导电通信”或“个人区域网络”）。 来自接收机的数据可下载到计算机中进行分析或显示。

公开(公告)号：US20050107658A1

公开(公告)日：2005-05-19

申请号：US10993826

申请日：2004-11-19

申请人： Brian Brockway

发明人： Brian Brockway

IPC分类号： A61M1/10 ,  A61M1/12 ,  A61N1/362 ,  B81C20060101

CPC分类号： A61M1/1086 ,  A61M1/101 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/3334 ,  A61M2205/8243

摘要： Various devices, systems and methods for providing effective, long term and reliable use of pressure feedback in VADs. Exemplary embodiments are described which provide for direct LV pressure measurement, non-invasive calibration techniques to detect ventricular collapse and recalibrate the feedback mechanism, improved pressure sensor designs with reduced drift, and barometric pressure correction schemes. These devices and methods may be used alone or in combination with each other, and may also be combined with other feedback mechanisms.

摘要翻译： 用于在VAD中提供有效，长期和可靠使用压力反馈的各种设备，系统和方法。 描述了提供直接LV压力测量，非侵入性校准技术以检测心室塌陷并重新校准反馈机制的示例性实施例，改进的减小漂移的压力传感器设计和大气压力校正方案。 这些装置和方法可以单独使用或者彼此组合使用，并且还可以与其他反馈机制组合使用。

公开(公告)号：US20090143692A1

公开(公告)日：2009-06-04

申请号：US12323828

申请日：2008-11-26

申请人： Marina V. Brockway ,  Vladimir V. Kovtun ,  Carlos A. Ricci

发明人： Marina V. Brockway ,  Vladimir V. Kovtun ,  Carlos A. Ricci

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/021 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/411 ,  A61B5/7275 ,  G06F19/00

摘要： In a method for determining a cardiac condition, a sensed physiologic signal for a period of time including multiple cardiac cycles is received. Using the received physiologic data, a heart beat frequency to be used as a reference frequency is determined. A plurality of harmonics of the received physiologic signal is extracted based on the reference frequency, wherein the harmonics correspond to a plurality of alternans frequencies. Amplitudes of at least some of the extracted harmonics are determined, and are used to determine an alternans indicator value.

摘要翻译： 在用于确定心脏状况的方法中，接收包括多个心动周期的一段时间的感测生理信号。 使用接收到的生理数据，确定要用作参考频率的心跳频率。 基于参考频率提取接收到的生理信号的多个谐波，其中谐波对应于多个交替频率。 确定提取的谐波中的至少一些的幅度，并且用于确定交替指示符值。

公开(公告)号：US20090030397A1

公开(公告)日：2009-01-29

申请号：US12033531

申请日：2008-02-19

申请人： Alyse Renee Stofer ,  Lynn Marlo Zweirs

发明人： Alyse Renee Stofer ,  Lynn Marlo Zweirs

IPC分类号： A61M31/00 ,  A61L33/06

CPC分类号： A61B5/0215 ,  A61B5/0002 ,  A61B5/031 ,  A61B5/036

摘要： Methods and apparatus of the present invention provide viscoelastic barrier materials for use as barriers in devices such as pressure measurement catheters. Improved barrier materials sometimes include at least one barrier material precursor combined with an amount of a softener. In other embodiments, two barrier material precursor components are combined without a softener to provide a fully cross-linked barrier material having certain softness characteristics. In various embodiments, a softener may be dimethyl silicone oil and may be combined with a barrier material precursor in an amount of between about 25% and about 45% by weight, relative to the final barrier material. Once a viscoelastic barrier material is prepared, it may be placed in a pressure transmission catheter or similar device, for example by injecting the gel into a lumen of the catheter via a syringe. Barrier materials of the present invention have one or more advantageous properties, such as a desired softness, full cross-linking, resistance to washout from a catheter, enhanced stability and/or the like.

摘要翻译： 本发明的方法和装置提供用作诸如压力测量导管的装置中的屏障的粘弹性屏障材料。 改进的阻隔材料有时包括与一定量的软化剂组合的至少一种阻隔材料前体。 在其它实施方案中，两种屏障材料前体组分在没有软化剂的情况下组合以提供具有某些柔软特性的完全交联的阻挡材料。 在各种实施方案中，柔软剂可以是二甲基硅油，并且可以相对于最终阻挡材料以约25重量％至约45重量％的量与阻隔材料前体组合。 一旦制备了粘弹性阻挡材料，其可以被放置在压力传递导管或类似装置中，例如通过经由注射器将凝胶注射到导管的内腔中。 本发明的阻隔材料具有一个或多个有利的性质，例如所需的柔软性，全部交联，抵抗从导管冲洗的抵抗力，增强的稳定性和/或类似物质。