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公开(公告)号：US12085559B2
公开(公告)日：2024-09-10
申请号：US17361860
申请日：2021-06-29
发明人： Thomas L. Smith , Edward Verdonk
IPC分类号： G01N33/487 , G01N27/38
CPC分类号： G01N33/48728 , G01N27/38
摘要： A plenum assembly configured for electrophysiology assays, such as patch clamp techniques, includes one or more ground electrode assemblies. The ground electrode assemblies are individually removable from a plenum base of the plenum assembly in a non-destructive manner, and may be reinstalled in the plenum base in a manner that reestablishes electrical contact with ground circuitry without requiring soldering or other additional steps. A rejuvenating apparatus is provided for rejuvenating one or more ground electrode assemblies removed from the plenum base.
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公开(公告)号：US20240161486A1
公开(公告)日：2024-05-16
申请号：US18470823
申请日：2023-09-20
发明人： Yousef Al-Kofahi , Michael MacDonald , Asha Singanamalli , Mohammed Yousefhussien , Will Marshall
IPC分类号： G06V10/82 , G06F18/2411 , G06F18/2413 , G06T7/11 , G06V10/764 , G06V10/776 , G06V10/94
CPC分类号： G06V10/82 , G06F18/2411 , G06F18/2413 , G06T7/11 , G06V10/764 , G06V10/776 , G06V10/945
摘要： In one aspect, a method for inspecting features of an image using an image inspection controller that includes a processor communicatively coupled to a memory is described. The method includes receiving, at the processor, an input image, performing, on the input image, one of a semantic segmentation process and an object classification process to generate an output image, and prompting a user to select between approving the displayed output image, and at least one of i) performing an additional semantic segmentation process on the displayed output image, and ii) performing an additional object classification process on the displayed output image.
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公开(公告)号：US20240069322A1
公开(公告)日：2024-02-29
申请号：US18259817
申请日：2022-01-05
发明人： Matthew Chan
CPC分类号： G02B21/367 , G02B21/06 , G02B21/242
摘要： A well tray includes a base including an upper surface, a lower surface and at least one edge surface connecting the upper surface to the lower surface. The at least one edge surface defines a slot. The slot is in communication with a magnet receiver at least partially defined between the upper surface and the lower surface. The magnet receiver is configured to slidably receive a removable magnet. The tray includes a plurality of wells disposed on an upper surface of the base.
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公开(公告)号：US11645752B2
公开(公告)日：2023-05-09
申请号：US17365710
申请日：2021-07-01
发明人： Avrum Cohen , Dihui Hong , Stephen Rhein
CPC分类号： G06V20/695 , G06K9/6254 , G06K9/6256 , G06T7/0014 , G06T2200/24 , G06T2207/10056 , G06T2207/20081 , G06T2207/30024
摘要： A system and method for analyzing images using programmable device is disclosed. A sequencer operating on the non-transitory programmable device applies the first image analysis step to the first image to develop annotated training data. Specifications of the first image and the first image analysis step are developed using a graphical user interface operating on a computer. In addition, a machine learning system trainer operating on the programmable device trains an untrained machine learning system to develop a trained machine learning system. When the trained machine learning system is presented with the first image as an input, the trained machine learning system develops a prediction of the annotated training data. In addition, the sequencer analyzes a second image by undertaking a workflow, wherein the workflow is received from the computer and is specified using the graphical user interface and comprises a second image analysis step that that specifies operating the trained machine learning system.
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公开(公告)号：US20220364990A1
公开(公告)日：2022-11-17
申请号：US17621991
申请日：2020-06-25
IPC分类号： G01N21/64 , G01N33/483 , G01N30/86
摘要： Methods and systems for analyzing oscillatory fluorescence representing an oscillatory ion flux associated with one or more biological cells. An illustrative method of analysis may comprise detecting fluorescence from one or more biological cells to produce a series of data points describing an oscillation pattern. A series of slopes may be calculated for the oscillation pattern. For example, a sliding window may be used to define subsets of the series of data points from which the series of slopes are calculated. Peaks of the oscillation pattern may be identified using the series of slopes. Primary peaks and secondary peaks, if any, in the oscillation pattern may be identified and characterized by multiple measurements. An aspect of the secondary peaks may be determined. Appearance of secondary peaks may indicate a potential risk of cardiotoxicity or neurotoxicity.
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公开(公告)号：US20220350130A1
公开(公告)日：2022-11-03
申请号：US17863804
申请日：2022-07-13
摘要： A computer-implemented system and method for template-based imaging are disclosed. A first image of a first slide, a second image of a second slide, and a third image of a third slide are received, wherein the third image includes a representation of a sample disposed on the third slide. Values of pixels of a template image that are associated with a plurality of features common to the first and second slides and represented in the first and second images are set to a non-background value and values of pixels of the template image not associated with the plurality of features are set to a background value. An offset between the template image and the third image is developed and coordinates of pixels in the third image that are associated with the representation of the sample are determined in accordance with the offset.
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公开(公告)号：US11465140B2
公开(公告)日：2022-10-11
申请号：US16632059
申请日：2018-07-09
发明人： Jason Briggs , Paula Gedraitis , Trisha A Mitlo
摘要： An object such as a cell colony may be picked from a plurality of objects by acquiring an image of the objects and an image of a pipette tip. The image of the objects is analyzed to select an object of interest. The selected object is associated with a coordinate position. Based on the coordinate position, the pipette tip is positioned over the selected object. An image of the pipette tip is then acquired and analyzed. The pipette tip is associated with a coordinate position. A positional error between the coordinate position of the selected object and the coordinate position of the pipette tip is determined. Based on the positional error, the pipette tip and/or a sample holder supporting the objects is moved to align the pipette tip over the selected object, by matching the coordinate position of the pipette tip with the coordinate position of the selected object.
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公开(公告)号：US20210334607A1
公开(公告)日：2021-10-28
申请号：US17216746
申请日：2021-03-30
发明人： Yousef Al-Kofahi , Michael MacDonald , Asha Singanamalli , Mohammed Yousefhussien , Will Marshall
摘要： In one aspect, a method for inspecting features of an image using an image inspection controller that includes a processor communicatively coupled to a memory is described. The method includes receiving, at the processor, an input image, performing, on the input image, one of a semantic segmentation process and an object classification process to generate an output image, and prompting a user to select between approving the displayed output image, and at least one of i) performing an additional semantic segmentation process on the displayed output image, and ii) performing an additional object classification process on the displayed output image.
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9.发明申请公开(公告)号：US20210333533A1
公开(公告)日：2021-10-28
申请号：US17368545
申请日：2021-07-06
发明人： Matthew Chan
摘要： A method and system for autofocusing an objective lens in a microscope system are disclosed. A decentered aperture is disposed in an optical path between an objective lens and an image plane of an image capturing device and a plurality of reference images are captured. Each reference image is captured when the objective lens is positioned at a corresponding z-position of a plurality of z-positions along an axis of travel of the objective lens and the optical path is at least partially occluded by the decentered aperture. At least one reference image of the plurality of the reference images is associated with a best focus position. The plurality of reference images are analyzed to develop a plurality of pattern locations, wherein each pattern location represents a position of a pattern formed on the image plane when a corresponding reference image was captured. The objective lens is positioned in accordance with the best focus position and the plurality of pattern locations.
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公开(公告)号：US20210325366A1
公开(公告)日：2021-10-21
申请号：US17361860
申请日：2021-06-29
发明人： Thomas L. Smith , Edward Verdonk
IPC分类号： G01N33/487 , G01N27/38
摘要： A plenum assembly configured for electrophysiology assays, such as patch clamp techniques, includes one or more ground electrode assemblies. The ground electrode assemblies are individually removable from a plenum base of the plenum assembly in a non-destructive manner, and may be reinstalled in the plenum base in a manner that reestablishes electrical contact with ground circuitry without requiring soldering or other additional steps. A rejuvenating apparatus is provided for rejuvenating one or more ground electrode assemblies removed from the plenum base.
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