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公开(公告)号：US20030224037A1
公开(公告)日：2003-12-04
申请号：US10270261
申请日：2002-10-11
申请人： Mebiopharm Co., Ltd.
IPC分类号： A61K039/395 , A61K031/728 , A61K038/40 , A61K031/525 , A61K009/127
CPC分类号： A61K31/555 , A61K47/62 , A61K47/6911
摘要： The present invention provides a liposome preparation containing oxaliplatin and derivatized with a hydrophilic polymer, as well as a pharmaceutical composition for treatment of tumor comprising the liposome preparation. The liposome preparation according to the present invention is characterized in that it is derivatized with a ligand. The ligand is preferably transferrin. In accordance with the invention, the uptake of a pharmaceutical agent in the liposome into tumor cells can be enhanced through transferrin receptors expressed on the surface of the tumor cells.
摘要翻译： 本发明提供含有奥沙利铂并用亲水性聚合物衍生的脂质体制剂，以及用于治疗包含脂质体制剂的肿瘤的药物组合物。 根据本发明的脂质体制剂的特征在于其用配体衍生化。 配体优选为转铁蛋白。 根据本发明，可以通过在肿瘤细胞表面表达的转铁蛋白受体来增强脂质体中药剂对肿瘤细胞的吸收。
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公开(公告)号：US08758810B2
公开(公告)日：2014-06-24
申请号：US12891568
申请日：2010-09-27
申请人： Kazushi Okada , Tadayuki Ibuki , Donghyun Kim , Tadashi Fujisawa
发明人： Kazushi Okada , Tadayuki Ibuki , Donghyun Kim , Tadashi Fujisawa
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K31/282 , A61K47/42
摘要： The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.
摘要翻译： 本公开提供含脂质的组合物，包括封装药物的靶向脂质体及其药物制剂，以及制备和使用含脂质组合物的方法，包括使用靶向脂质体治疗癌症和其它疾病 。
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公开(公告)号：US20090110643A1
公开(公告)日：2009-04-30
申请号：US11920836
申请日：2005-05-23
CPC分类号： A61K49/223 , A61K9/127 , A61K41/0028 , A61K47/6911 , A61K48/0008
摘要： Gas-filled liposomes that are useful for ultrasonography and ultrasound therapy are provided. A method of producing the gas-filled liposomes, including filling the void space in a sealed container containing a liposome suspension in a volume amounting to 20 to 80% of the inner capacity thereof with a fluoride gas or a nitrogen gas, and subjecting the container to an ultrasonication.
摘要翻译： 提供了可用于超声和超声治疗的充气脂质体。 一种制造气体充填脂质体的方法，包括用含有氟化物气体或氮气的容积为20〜80％体积的含有脂质体悬浮液的密闭容器填充空隙，并对容器 超声波。
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公开(公告)号：US20140363491A1
公开(公告)日：2014-12-11
申请号：US14274377
申请日：2014-05-09
申请人： Mebiopharm Co., Ltd.
发明人： Kazushi OKADA , Tadayuki IBUKI , Donghyun KIM , Tadashi FUJISAWA
IPC分类号： A61K9/127 , A61K47/42 , A61K31/282
CPC分类号： A61K9/1271 , A61K31/282 , A61K47/42
摘要： The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.
摘要翻译： 本公开提供含脂质的组合物，包括封装药物的靶向脂质体及其药物制剂，以及制备和使用含脂质组合物的方法，包括使用靶向脂质体治疗癌症和其它疾病 。
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公开(公告)号：US20040022842A1
公开(公告)日：2004-02-05
申请号：US10454392
申请日：2003-06-03
申请人： Mebiopharm Co., Ltd.
IPC分类号： A61K039/395 , A61K009/127 , A61K031/728
CPC分类号： A61K31/555
摘要： The present invention provides a liposome preparation containing oxaliplatin and derivatized with a hydrophilic polymer and a ligand. In one embodiment the hydrophilic polymer is polyethylene glycol and the ligand is transferrin. In accordance with the invention, the uptake of a pharmaceutical agent contained in the liposome into tumor cells can be enhanced through transferrin receptors expressed on the surface of the tumor cells. Also provided are pharmaceutical compositions containing the liposomes and methods of their use.
摘要翻译： 本发明提供含有奥沙利铂并用亲水性聚合物和配体衍生化的脂质体制剂。 在一个实施方案中，亲水性聚合物是聚乙二醇，配体是转铁蛋白。 根据本发明，可以通过在肿瘤细胞表面上表达的转铁蛋白受体来增强脂质体中所含的药物对肿瘤细胞的摄取。 还提供含有脂质体的药物组合物及其使用方法。
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公开(公告)号：US20110081404A1
公开(公告)日：2011-04-07
申请号：US12891568
申请日：2010-09-27
申请人： Kazushi Okada , Tadayuki Ibuki , Donghyun Kim , Tadashi Fujisawa
发明人： Kazushi Okada , Tadayuki Ibuki , Donghyun Kim , Tadashi Fujisawa
IPC分类号： A61K9/127 , A61K31/437 , A61K31/7088 , A61K33/24 , A61K31/282 , A61K38/40 , A61P35/00
CPC分类号： A61K9/1271 , A61K31/282 , A61K47/42
摘要： The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.
摘要翻译： 本公开提供含脂质的组合物，包括封装药物的靶向脂质体及其药物制剂，以及制备和使用含脂质组合物的方法，包括使用靶向脂质体治疗癌症和其它疾病 。
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公开(公告)号：US07829113B2
公开(公告)日：2010-11-09
申请号：US11371586
申请日：2006-03-08
申请人： Kazushi Okada , Tadayuki Ibuki , Donghyun Kim , Tadashi Fujisawa
发明人： Kazushi Okada , Tadayuki Ibuki , Donghyun Kim , Tadashi Fujisawa
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K31/282 , A61K47/42
摘要： The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.
摘要翻译： 本公开提供含脂质的组合物，包括封装药物的靶向脂质体及其药物制剂，以及制备和使用含脂质组合物的方法，包括使用靶向脂质体治疗癌症和其它疾病 。
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公开(公告)号：US20090214629A1
公开(公告)日：2009-08-27
申请号：US11915474
申请日：2005-05-26
IPC分类号： A61K9/127 , C12N15/87 , A61K31/7088
CPC分类号： C12N15/88 , A61K9/0009 , A61K9/127 , A61K9/1272 , A61K41/0028 , A61K47/42 , A61K48/00 , A61K48/0008 , A61N7/00
摘要： A method for efficiently transferring a gene to a target cell is provided. A method of transferring a gene to a target cell, including adding or administering a positively charged complex (A) composed of the gene and a cationic substance and gas-filled microparticles (B) to a target cell-containing composition or a living body and then exposing the target cell-containing composition or the living body to a low-frequency ultrasound.
摘要翻译： 提供了将基因有效转移到靶细胞的方法。 将基因转移到靶细胞的方法，包括将由该基因构成的带正电荷的复合物（A）和阳离子性物质和充气微粒（B）添加或给予含靶细胞的组合物或活体， 然后将含靶细胞的组合物或活体暴露于低频超声波。
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