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公开(公告)号：US11581175B2
公开(公告)日：2023-02-14
申请号：US16334329
申请日：2017-09-19
发明人： Nicholas Manicke , Chengsen Zhang
摘要： Mass spectrometry cartridge including a base in mechanical communication with a spray substrate holder, an absorbent pad between the base and the spray substrate holder, a translatable sample well holder interposed between the spray substrate holder and a top cover, the top cover configured to house a conductive element, wherein when the translatable sample well holder is in a first position, the translatable well holder is vertically above the absorbent pad, when the translatable sample well holder is in a second position, the translatable well holder is vertically above a spray substrate are disclosed. Methods of analyzing a sample are also disclosed.
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公开(公告)号：US11460861B2
公开(公告)日：2022-10-04
申请号：US16486104
申请日：2018-02-16
IPC分类号： G05D1/02 , B60W60/00 , G05D1/00 , H04L67/1001 , H04L67/125 , H04L67/562 , H04L67/565
摘要： A method of controlling an operation of a robot (102) is provided using a cluster of nodes (104) in a network (106). The method includes receiving, using a gateway cloud driver (108), robot state information from the robot (102) via the network (106), and converting, using the gateway cloud driver (108), the robot state information into at least one message. The method further includes transmitting, using a message broker (110), the at least one message to the cluster of nodes (104) via the network (106). The method further includes processing, using the cluster of nodes (104) in the network (106), the at least one message by parallel computing, and generating, using the cluster of nodes (104) in the network (106), a robot command to control the operation of the robot (102).
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公开(公告)号：US20220211700A1
公开(公告)日：2022-07-07
申请号：US17613000
申请日：2020-05-22
申请人： Indiana University Research and Technology Corporation , The United States Government as Represented by the Department of Veterans Affairs
IPC分类号： A61K31/496 , A61K31/202 , A61K33/00 , A61K45/06
摘要： Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for memory dysfunction, Alzheimer's disease, and cognitive decline. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in improving memory, as well as for preventing and treating memory disorders, Alzheimer's disease and cognitive decline. All the above-mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed.
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公开(公告)号：US11351268B2
公开(公告)日：2022-06-07
申请号：US16983726
申请日：2020-08-03
IPC分类号： A61K47/66 , C07K14/50 , A61K47/65 , A61P3/04 , A61P3/10 , A61K38/03 , A61K38/17 , A61K38/26 , A61K38/28
摘要： Disclosed herein are modified C-terminal fragments of FGF21 optimized for binding to Klotho β or antagonizing FGF21 activity. FGF21 peptides modified to comprise modifications to the C-terminal amino acid sequence are disclosed that have enhanced activity at the FGF21 receptor. Additionally, conjugates formed between the optimized FGF21 peptide fragments and insulin like peptides or nuclear hormone receptor ligands are provided.
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公开(公告)号：US20220089577A1
公开(公告)日：2022-03-24
申请号：US17388906
申请日：2021-07-29
IPC分类号： C07D405/14 , C07D405/06 , C07D409/06 , C12N15/90 , A61P43/00
摘要： The present disclosure relates to certain compounds having binding affinity for Ku, and uses thereof. Specifically, the present disclosure relates to the use of Ku inhibitors as described herein in site-specific genome engineering technologies, including but not limited to CRISPR/Cas9, Zinc finger nuclease (ZFN), Transcription activator-like effector nuclease (TALEN), and meganuclease. The present disclosure also relates to kits useful for site-specific genome engineering that include at least one compound as described herein.
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公开(公告)号：US20220079948A1
公开(公告)日：2022-03-17
申请号：US17416947
申请日：2019-12-20
IPC分类号： A61K31/519 , A61K45/06 , A61K31/138 , G01N33/577
摘要： Therapeutic compositions comprising one or more agents that inhibit the Nef-PAK2 interface, and methods of administering those therapeutic compositions to model, treat, reduce resistance to treatment, prevent, and diagnose a condition/disease associated with HIV-infection or a related clinical condition thereof, are disclosed.
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公开(公告)号：US11254954B2
公开(公告)日：2022-02-22
申请号：US15540326
申请日：2015-12-21
发明人： James McKinlay , Amanda Posto , Timothy Kremer , Breah LaSarre
摘要： Chemically defined culture medium and culture conditions that allow bacteria to assimilate dinitrogen gas (N2) as a nitrogen source during bio-ethanol production are disclosed herein. Methods of bioethanol production using the chemically defined culture medium and culture conditions are also disclosed.
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8.发明申请公开(公告)号：US20210252308A1
公开(公告)日：2021-08-19
申请号：US16973738
申请日：2019-06-10
发明人： Jian-Yue Jin , Wenhu Pi , Feng-Ming Kong , Weili Wang
摘要： Methods for directly measuring a patient's relative sensitivity to radiation therapy are provided. In particular, the methods provide for calculating a radiation sensitivity quotient for monocytes in culture. The methods can be incorporated into radiotherapy (RT) treatment planning systems, which are also provided. The methods can be used to optimize patient treatment plans, thereby developing patient-specific radiation treatment plans. Methods for treating a patient with radiotherapy with an optimized treatment plan are provided.
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公开(公告)号：US11082447B2
公开(公告)日：2021-08-03
申请号：US15999673
申请日：2017-02-17
发明人： L. Jean Camp
摘要： A system comprising a processor in electrical communication with a network and a non-transitory memory having instructions that, in response to an execution by the processor, cause the processor to monitor a routing information base (“RIB”) of the network, identify a change in the RIB, calculate a probability of suspiciousness of the change in the RIB, and classify the change in the RIB based on a continuum of trust are disclosed. Methods of managing routers are also disclosed.
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公开(公告)号：US20210228538A1
公开(公告)日：2021-07-29
申请号：US17226781
申请日：2021-04-09
IPC分类号： A61K31/353 , A61K31/343 , A61K31/335 , A61P27/02 , A61K39/395
摘要： Compositions including the combination of cremastranone analogs and anti-angiogenic agents and the use of the compositions for targeting ocular angiogenesis such as seen in neovascular eye diseases are disclosed.
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