公开(公告)号：US20100021500A1

公开(公告)日：2010-01-28

申请号：US12583271

申请日：2009-08-18

申请人： Yaron Ilan ,  Elazar Rabbani ,  Dean L. Engelhardt ,  Israel Gotsman ,  James J. Donegan

发明人： Yaron Ilan ,  Elazar Rabbani ,  Dean L. Engelhardt ,  Israel Gotsman ,  James J. Donegan

IPC分类号： A61K39/29 ,  A61K39/00 ,  A61P37/04

CPC分类号： A61K39/0005 ,  A61K38/00 ,  A61K39/001 ,  A61K39/12 ,  A61K39/292 ,  A61K2035/122 ,  A61K2039/5152 ,  A61K2039/542 ,  A61K2039/57 ,  C12N2730/10134

摘要： This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.

摘要翻译： 本发明提供了用于治疗应用的新方法，包括治疗携带感染性物质或具有受损的自身免疫或免疫病症受损的受试者。 本文公开的治疗应用还涉及用含有癌细胞或恶性或癌细胞的恶性肿瘤治疗癌性受试者。 还提供了预防受试者感染的疫苗接种过程。 该新颖方法包括向受试者引入或施用一种或多种抗原或训练或采用的免疫细胞。 这些抗原或免疫细胞能够建立或增加至少一种第一特异性免疫应答并减少至少一种第二特异性免疫应答。 这些反应包括组分，如细胞免疫反应元件，体液免疫反应元件和细胞因子，后者还包括干扰素和淋巴因子。 本发明也提供有用的组合物。