-
公开(公告)号：US20110281943A1
公开(公告)日：2011-11-17
申请号：US13097976
申请日：2011-04-29
Applicant: Pei Min Lee , Leon Hides , Jen Han Lee , Man Li Peng , Lin Chiao Chen
Inventor： Pei Min Lee , Leon Hides , Jen Han Lee , Man Li Peng , Lin Chiao Chen
CPC classification number: A61Q19/02 , A61K8/676 , A61K2800/522
Abstract: The present invention discloses topical composition comprising ascorbic acid derivatives. The inventive topical composition that the ascorbic acid derivatives is homogeneously incorporated therein can make the ascorbic acid derivatives more widely used as active ingredient in skin topical formulation.
Abstract translation: 本发明公开了包含抗坏血酸衍生物的局部组合物。 将抗坏血酸衍生物均匀地并入其中的本发明的局部组合物可以使抗坏血酸衍生物在皮肤局部制剂中更广泛地用作活性成分。
-
2.发明授权公开(公告)号：US08053474B2
公开(公告)日：2011-11-08
申请号：US12648626
申请日：2009-12-29
Applicant: Wei-Chuan Tsai , Chen-Yin Chen , Ming-Yi Chiu , Yi-Fan Ling , Nai-Hsuan Hsu
Inventor： Wei-Chuan Tsai , Chen-Yin Chen , Ming-Yi Chiu , Yi-Fan Ling , Nai-Hsuan Hsu
IPC: C07C229/00 , A61K31/195
CPC classification number: C07C233/36 , A61K8/42 , A61Q19/02
Abstract: The present invention discloses compounds with a carboxyl acid group and an amide group which also containing the tertiary amino groups. The carboxyl acid group having a partial negative charge can attract the tertiary amino group with each other to form a quaternary ammonium salt structure, so that the compounds are easy to dissolve in water. Moreover, these compounds having a mushroom tyrosinase-inhibition effect and have the potential to use in the cosmetics for skin whitening.
Abstract translation: 本发明公开了也含有叔氨基的具有羧酸基和酰胺基的化合物。 具有部分负电荷的羧酸基团可以相互吸引叔氨基以形成季铵盐结构，使得化合物容易溶于水。 此外，这些化合物具有蘑菇酪氨酸酶抑制作用，并且具有在化妆品中用于皮肤美白的潜力。
-
公开(公告)号：US20100056809A1
公开(公告)日：2010-03-04
申请号：US12553220
申请日：2009-09-03
Applicant: Wei-Chuan Tsai , Chen-Yin Chen , Ming-Yi Chiu , Yi-Fan Ling , Nai-Hsuan Hsu
Inventor： Wei-Chuan Tsai , Chen-Yin Chen , Ming-Yi Chiu , Yi-Fan Ling , Nai-Hsuan Hsu
IPC: C07D307/62
CPC classification number: C07D407/04 , C07D307/62
Abstract: The present invention discloses the ascorbic acid derivatives. The inventive molecules that combine with one or two hydrophilic headgroups connected by a hydrophobic spacer can increase skin penetration.
Abstract translation: 本发明公开了抗坏血酸衍生物。 与通过疏水间隔物连接的一个或两个亲水头基组合的本发明分子可以增加皮肤渗透性。
-
公开(公告)号：US11459288B2
公开(公告)日：2022-10-04
申请号：US16933212
申请日：2020-07-20
Applicant: CORUM INC.
Inventor： Nai-Hsuan Hsu
Abstract: A process for preparing azelaic acid is disclosed. In particular, the process for preparing azelaic acid is an ozone free process. The process for preparing azelaic acid comprises a step of decarboxylation of tetra-carboxylic acid in the presence of a organic sulfonic acid.
-
5.发明申请Novel Glycine Derivative Capable Of Inhibiting Melanin Formation And Composition Using The Same 有权能够抑制黑色素形成的新型甘氨酸衍生物和使用它的组合物公开(公告)号：US20140134121A1
公开(公告)日：2014-05-15
申请号：US14159741
申请日：2014-01-21
Applicant: CORUM INC.
Inventor： Nai-Hsuan Hsu , Chiao-Yi Hsu , Ssu-Ching Wang , Ting-Wan Chen , Chu-Yi Pang
CPC classification number: C07C233/47 , A61K8/44 , A61Q19/02 , A61Q19/08 , C07C237/22
Abstract: The invention provides a method for inhibiting melanin formation composition by applying a glycine derivative, having a structure shown in the following general equation (I): wherein R1 represents a C1-C4 alkyl group; R2 represents a hydrogen atom or a methyl group; and n represents an integer of 1-6.
Abstract translation: 本发明提供一种通过应用具有以下通式（I）所示结构的甘氨酸衍生物来抑制黑色素形成组合物的方法：其中R1表示C1-C4烷基; R2表示氢原子或甲基; n表示1-6的整数。
-
Patent Agency Ranking
公开(公告)号：US20110065954A1
公开(公告)日：2011-03-17
申请号：US12648626
申请日：2009-12-29
Applicant: Wei-Chuan Tsai , Chen-Yin Chen , Ming-Yi Chiu , Yi-Fan Ling , Nai-Hsuan Hsu
Inventor： Wei-Chuan Tsai , Chen-Yin Chen , Ming-Yi Chiu , Yi-Fan Ling , Nai-Hsuan Hsu
IPC: C07C229/00
CPC classification number: C07C233/36 , A61K8/42 , A61Q19/02
Abstract: The present invention discloses compounds with a carboxyl acid group and an amide group which also containing the tertiary amino groups. The carboxyl acid group having a partial negative charge can attract the tertiary amino group with each other to form a quaternary ammonium salt structure, so that the compounds are easy to dissolve in water. Moreover, these compounds having a mushroom tyrosinase-inhibition effect and have the potential to use in the cosmetics for skin whitening.
Abstract translation: 本发明公开了也含有叔氨基的具有羧酸基和酰胺基的化合物。 具有部分负电荷的羧酸基团可以相互吸引叔氨基以形成季铵盐结构，使得化合物容易溶于水。 此外，这些化合物具有蘑菇酪氨酸酶抑制作用，并且具有在化妆品中用于皮肤美白的潜力。
-
公开(公告)号：US20210047257A1
公开(公告)日：2021-02-18
申请号：US16933212
申请日：2020-07-20
Applicant: CORUM INC.
Inventor： Nai-Hsuan Hsu
Abstract: A process for preparing azelaic acid is disclosed. In particular, the process for preparing azelaic acid is an ozone free process. The process for preparing azelaic acid comprises a step of decarboxylation of tetra-carboxylic acid in the presence of a organic sulfonic acid.
-
8.发明申请Method for Inhibiting Inflammation and Reducing Melanophilin Expression with Glycine Derivatives And the Composition Thereof 审中-公开用甘氨酸衍生物抑制炎症和减少黑曲霉表达的方法及其组成公开(公告)号：US20140314697A1
公开(公告)日：2014-10-23
申请号：US14255114
申请日：2014-04-17
Applicant: CORUM INC.
Inventor： Ssu-Ching Wang , Pei-Hsuan Wu , Jun-Yi Yao , Nai-Hsuan Hsu
IPC: C07C237/06 , A61Q19/02 , A61K8/42
Abstract: This invention discloses method for inhibiting inflammation and reducing melanophilin expression with glycine derivatives and the composition thereof. The mentioned glycine derivatives can not only efficiently inhibit skin inflammation, but also can present significant melanophilin expression reduction. This mentioned composition of this invention comprises the glycine derivatives, and shows melanophilin expression reduction and anti-inflammatory effect. The mentioned composition can be applied in topical cosmetic or pharmaceutical compositions as skin care preparations, or functional preparations.
Abstract translation: 本发明公开了用甘氨酸衍生物抑制炎症和减少黑色素细胞表达的方法及其组成。 所提及的甘氨酸衍生物不仅可以有效抑制皮肤炎症，而且可以显示出显着的黑色素细胞表达降低。 本发明提及的组合物包含甘氨酸衍生物，并显示黑色素细胞表达降低和抗炎作用。 所提及的组合物可以用于局部化妆品或药物组合物中作为护肤制剂或功能制剂。
-
9.发明申请Composition for Stabilizing Ascorbic Acid Derivatives and the Application Thereof 审中-公开稳定抗坏血酸衍生物的组合物及其应用公开(公告)号：US20140155633A1
公开(公告)日：2014-06-05
申请号：US13689971
申请日：2012-11-30
Applicant: CORUM INC.
Inventor： Lin-Chao Chen , Yu-Ling Shiu , Chia-Pei Lee , Chao-Yang Lee
IPC: C07D307/33
CPC classification number: A61K8/676 , A61K8/55 , A61K9/0014 , A61K31/375 , A61K47/12 , A61K2800/10 , A61Q19/00
Abstract: This invention discloses a composition for stabilizing ascorbic acid derivative and the application thereof. The mentioned composition comprises ascorbic acid derivative, buffer, phosphonic acid derivative and at least one alcohol. The yellowish and degradation of ascorbic acid derivative can be efficiently decreased by the mentioned composition. Moreover, the mentioned composition can be used in topical composition, such as toner, serum, lotion, cream.
Abstract translation: 本发明公开了一种用于稳定抗坏血酸衍生物的组合物及其应用。 所述组合物包含抗坏血酸衍生物，缓冲液，膦酸衍生物和至少一种醇。 通过所述组合物可以有效降低抗坏血酸衍生物的变黄和降解。 此外，所提及的组合物可用于局部组合物，例如调色剂，血清，洗剂，霜剂。
-
10.发明授权Process for synthesis of androstane 17-β carbothioic acid and relative compounds thereof 有权雄甾烷17-＆bgr的合成方法 硫代硫酸及其相关化合物公开(公告)号：US07935837B2
公开(公告)日：2011-05-03
申请号：US12112229
申请日：2008-04-30
Applicant: Nai-Hsuan Hsu , Chu-Yi Pang , Chien-Jen Wu , Chi-Jen Huang , Chia-Jung Hsu , Peimin Lee
Inventor： Nai-Hsuan Hsu , Chu-Yi Pang , Chien-Jen Wu , Chi-Jen Huang , Chia-Jung Hsu , Peimin Lee
IPC: C07J3/00
CPC classification number: C07J3/00
Abstract: A process for synthesis of androstane 17-β carbothioic acid is provided. The process includes mixing an androstane 17-β carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-β carbothioic acid, wherein the androstane 17-β carbothioic acid has the formula (I): wherein R1 represents hydrogen or haloalkyl groups, R2 represents C1-8 linear alkyl groups, C1-8 branched alkyl groups, C1-6 unsaturated acyclic groups or aromatic groups, R3 represents hydrogen or hydroxyl, R4 represents hydrogen, bromine, chlorine or fluorine and R5 represents hydrogen, bromine, chlorine or fluorine. The process is a one-pot reaction.
Abstract translation: 雄甾烷17-＆bgr的合成方法 提供硫代酸。 该方法包括混合雄甾烷17-和bgr; 羧酸和偶联剂，并加入链烷硫醚以形成雄甾烷17-和bgr; 硫代硫酸，其中雄甾烷17-＆bgr; 硫代硫酸具有式（I）：其中R 1表示氢或卤代烷基，R 2表示C 1-8直链烷基，C 1-8支链烷基，C 1-6不饱和非环基或芳基，R 3表示氢或羟基，R 4 表示氢，溴，氯或氟，R5表示氢，溴，氯或氟。 该过程是一锅反应。
-
-
-
-
-
-
-
-
-
Search Results
17
records
(took 0.17 seconds)
