公开(公告)号：US08102528B2

公开(公告)日：2012-01-24

申请号：US12549781

申请日：2009-08-28

申请人： Clark Adrien Merchant ,  Peter Oma

发明人： Clark Adrien Merchant ,  Peter Oma

IPC分类号： G01J1/00 ,  G01N15/02 ,  G01N37/00

CPC分类号： G01N15/0205 ,  G01N2015/0693

摘要： The present invention provides a particle standard including particles having optical properties similar to those of a carrier in which the particles are dispersed, as well as a method of calibrating or validating a subject optical particle analyzer with respect to a reference optical particle analyzer by using the particle standard. In the method, the particle standard is analyzed with the reference optical particle analyzer to obtain a reference particle concentration and a reference particle-size distribution. Analogously, the particle standard is analyzed with the subject optical particle analyzer to obtain a subject particle concentration and a subject particle-size distribution. The subject particle concentration and the subject particle-size distribution are then compared to the reference particle concentration and the reference particle-size distribution, respectively, and the subject optical particle analyzer is adjusted accordingly.

摘要翻译： 本发明提供一种颗粒标准品，其包括具有与其中分散颗粒的载体类似的光学性质的颗粒，以及通过使用本发明的方法校准或验证目标光学颗粒分析仪相对于参考光学颗粒分析仪的方法 颗粒标准。 在该方法中，使用参考光学粒子分析仪分析颗粒标准，以获得参考颗粒浓度和参考颗粒尺寸分布。 类似地，用目标光学粒子分析仪分析颗粒标准物，以获得目标颗粒浓度和目标颗粒尺寸分布。 然后将目标颗粒浓度和目标颗粒尺寸分布与参考颗粒浓度和参考颗粒尺寸分布进行比较，并相应地调节目标光学颗粒分析仪。

公开(公告)号：US07859664B2

公开(公告)日：2010-12-28

申请号：US12209260

申请日：2008-09-12

申请人： Peter Oma ,  Deepak Kumar Sharma

发明人： Peter Oma ,  Deepak Kumar Sharma

IPC分类号： G01N15/02

CPC分类号： G01N15/0205 ,  G01N2015/0693

摘要： The present invention provides a plurality of samples, each of which includes particles of a predetermined particle dimension, within narrow predetermined limits, dispersed in a carrier at a predetermined particle concentration. The predetermined particle dimension and the predetermined particle concentration are the same for each sample. However, advantageously, each sample has a different predetermined ratio of a value of an optical property of the particles to a value of the same optical property of the carrier. The present invention also provides a method for selecting a target sample from the plurality of samples to assess the measurement accuracy or the detection sensitivity of an optical particle analyzer as the predetermined ratio approaches 1.

摘要翻译： 本发明提供了多个样品，每个样品包括预定的颗粒尺寸的颗粒，在窄的预定限度内，以预定的颗粒浓度分散在载体中。 对于每个样品，预定的颗粒尺寸和预定的颗粒浓度是相同的。 然而，有利地，每个样品具有颗粒的光学性质的值与载体的相同光学性质的值的不同的预定比率。 本发明还提供了一种用于从多个样品中选择目标样品的方法，以在预定比例接近1时评估光学粒子分析仪的测量精度或检测灵敏度。

公开(公告)号：US07605919B2

公开(公告)日：2009-10-20

申请号：US11925968

申请日：2007-10-28

申请人： Peter Oma ,  Jarret A. Diggins ,  Antonio J. G. Matias

发明人： Peter Oma ,  Jarret A. Diggins ,  Antonio J. G. Matias

IPC分类号： G01N21/00

CPC分类号： G01N15/1463

摘要： A method and apparatus for analyzing particles in a fluid, such as proteinaceous particles in a pharmaceutical formulation intended for parenteral delivery, are disclosed. The method comprises arranging a fluid to form a wide and shallow stream, acquiring a sequence of magnified still images of the stream, and processing said images, so as to highlight images of particles in the flowing fluid. The apparatus includes a light source, a flow cell, a lens with increased depth of view, a detector array, and a processor for acquiring and processing the images of particles in the fluid stream.

摘要翻译： 公开了用于分析流体中的颗粒的方法和装置，例如用于肠胃外递送的药物制剂中的蛋白质颗粒。 该方法包括布置流体以形成宽浅的流，获取流的放大静止图像的序列，以及处理所述图像，以便突出流动流体中的颗粒的图像。 该装置包括光源，流动池，具有增加的视角的透镜，检测器阵列和用于获取和处理流体流中的颗粒的图像的处理器。