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1.发明申请公开(公告)号：US20190216802A1
公开(公告)日：2019-07-18
申请号：US16365101
申请日：2019-03-26
IPC分类号： A61K31/485 , A61K9/20 , A61K9/08 , A61P25/30 , A61P25/00 , A61P25/32 , A61K31/167
CPC分类号： A61K31/485 , A61K9/08 , A61K9/20 , A61K31/167 , A61P25/00 , A61P25/30 , A61P25/32 , A61K2300/00
摘要： Disclosed are compositions for the treatment of emotional pain, physical pain, and insomnia comprising a compound comprising an opioid antagonist that treats pain by blocking Toll-like receptor 4 (TLR4). Examples of opioid antagonist include naltrexone and naloxone, and their use in the treatment, prevention, and reversal of pain.
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2.发明授权Combinations of opioid/TLR4 antagonists and acetyl-para-aminophenol (APAP) for use in the treatment of pain 有权用于治疗疼痛的阿片样物质/ TLR4拮抗剂和乙酰基对氨基苯酚（APAP）的组合公开(公告)号：US09095548B2
公开(公告)日：2015-08-04
申请号：US13837099
申请日：2013-03-15
IPC分类号： A61K31/167 , A61K31/485 , A61K45/06
CPC分类号： A61K31/485 , A61K31/167 , A61K45/06
摘要： Disclosed are compositions for the treatment of pain comprising a first compound and a second compound, the first compound is an opioid antagonist that treats pain by blocking Toll-like receptor 4 (TLR4) and the second compound is acetyl-para-aminophenol (APAP) that enhances the pain treatment effect of the first compound. Examples of opioid antagonist include naltrexone and naloxone, synergistic pharmaceutical compositions thereof, and their use in the treatment, prevention, and reversal of neuropathic and nociceptive pain.
摘要翻译： 公开了用于治疗疼痛的组合物，其包含第一化合物和第二化合物，第一化合物是通过阻断Toll样受体4（TLR4）治疗疼痛的阿片样物质拮抗剂，第二化合物是乙酰基对氨基苯酚（APAP） 这增强了第一化合物的疼痛治疗效果。 阿片类拮抗剂的实例包括纳曲酮和纳洛酮，其协同药物组合物及其在治疗，预防和逆转神经性疼痛和伤害性疼痛中的用途。
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公开(公告)号：US09707225B2
公开(公告)日：2017-07-18
申请号：US14812698
申请日：2015-07-29
IPC分类号： A61K31/167 , A61K31/485 , A61K45/06
CPC分类号： A61K31/485 , A61K31/167 , A61K45/06
摘要： Disclosed are compositions for the treatment of pain comprising a first compound and a second compound, the first compound is an opioid antagonist that treats pain by blocking Toll-like receptor 4 (TLR4) and the second compound is acetyl-para-aminophenol (APAP) that enhances the pain treatment effect of the first compound. Examples of opioid antagonist include naltrexone and naloxone, synergistic pharmaceutical compositions thereof, and their use in the treatment, prevention, and reversal of neuropathic and nociceptive pain.
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4.发明授权Combinations of opiod/TLR4 antagonist and a cyclooxygenase (COX) inhibitor for use in the treatment of pain 有权阿片/ TLR4拮抗剂与环氧合酶（COX）抑制剂的组合用于治疗疼痛公开(公告)号：US09205081B2
公开(公告)日：2015-12-08
申请号：US13841100
申请日：2013-03-15
IPC分类号： A61K31/485 , A61K31/192 , A61K45/06
CPC分类号： A61K31/485 , A61K31/192 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions for treatment of pain comprising a first compound and a second compound, the first compound is an opioid antagonist that treats pain by blocking Toll-like receptor 4 (TLR4) and the second compound is a cyclooxygenase (COX) inhibitor that enhances the pain treatment effect of the first compound. Examples of opioid antagonist include naltrexone and naloxone. Examples of cyclooxygenase inhibitors include ibuprofen, naproxen, meloxicam, diclofenac and meclofenamic acid, synergistic pharmaceutical compositions thereof, and their use in the treatment, prevention, and reversal of neuropathic pain and nociceptive pain with an allodynic component.
摘要翻译： 公开了用于治疗疼痛的组合物，其包含第一化合物和第二化合物，第一化合物是通过阻断Toll样受体4（TLR4）治疗疼痛的阿片样物质拮抗剂，第二化合物是环氧合酶（COX）抑制剂，其增强 第一化合物的疼痛治疗效果。 阿片类拮抗剂的实例包括纳曲酮和纳洛酮。 环加氧酶抑制剂的实例包括布洛芬，萘普生，美洛昔康，双氯芬酸和甲氯芬那酸，其协同药物组合物，以及它们用于治疗，预防和逆转神经性疼痛和具有异常性疼痛组分的伤害感受疼痛的用途。
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