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    METHOD AND APPARATUS FOR CULTIVATING CELLS UTILIZING WAVE MOTION
    81.
    发明申请
    METHOD AND APPARATUS FOR CULTIVATING CELLS UTILIZING WAVE MOTION 有权
    用于使用波浪运动来培养细胞的方法和装置

    公开(公告)号：US20080160597A1

    公开(公告)日：2008-07-03

    申请号：US11964874

    申请日：2007-12-27

    Applicant: Pieter van der Heiden ,  Marc Buevink ,  Nicolaas Marius Gerard Oosterhuis

    Inventor： Pieter van der Heiden ,  Marc Buevink ,  Nicolaas Marius Gerard Oosterhuis

    IPC: C12N1/20 ,  C12M1/00

    CPC classification number: C12M23/14 ,  B01F11/0025 ,  B01F13/1013 ,  B01F13/1022 ,  C12M23/28 ,  C12M23/58 ,  C12M27/16 ,  C12M35/04 ,  C12M41/44

    Abstract: A method for cultivating cells utilizing wave motion comprises the steps of: providing a container; introducing a gas containing oxygen, a liquid medium and a cell culture into the container; moving the container such that the container swivels with respect to a substantially horizontal pivot axis to thereby induce a wave motion to the liquid medium in the container, which wave motion contributes to the necessary oxygen transfer and mixing required for cell growth. During said swivelling of the container said pivot axis follows a cyclical closed-loop path. Also provided is an apparatus for performing said method, and an assembly for said method. Further part of the invention are disposable bags for cell or bacterial culture of which the volume can be changed in situ by opening or closing compartments of the bag and/or bags with essentially straight corners.

    Abstract translation: 利用波浪运动培养细胞的方法包括以下步骤：提供容器; 将含有氧气，液体介质和细胞培养物的气体引入容器中; 移动容器使得容器相对于基本上水平的枢转轴线旋转，从而引起对容器中的液体介质的波浪运动，该波浪运动有助于电池生长所需的必要的氧气传递和混合。 在所述容器的所述旋转期间，所述枢转轴线遵循循环闭环路径。 还提供了一种用于执行所述方法的装置，以及用于所述方法的装置。 本发明的另一部分是用于细胞或细菌培养的一次性袋，其容积可以通过打开或关闭具有基本上直角的袋和/或袋的隔室来原位改变。

    Intelligent reversible/replaceable bottom plates for fluid mixers
    82.
    发明申请
    Intelligent reversible/replaceable bottom plates for fluid mixers 失效

    公开(公告)号：US20070211569A1

    公开(公告)日：2007-09-13

    申请号：US11372309

    申请日：2006-03-09

    Applicant: Christopher Khoo ,  William Miller

    Inventor： Christopher Khoo ,  William Miller

    IPC: B01F11/00

    CPC classification number: B01F11/0025 ,  B01F15/00253 ,  B01F15/00753 ,  B01F2215/005 ,  Y10S366/605

    Abstract: A fluid mixer is disclosed which alters or changes the operation of the automatic clamping mechanism for different sizes, shapes and styles of containers. Removable and replaceable bottom plates are used on the lower base. These bottom plates have indicia on the resting surfaces thereof which provides the user with a clear indication as to which type of container is used with each plate surface. Typically, both surfaces of the replaceable/reversible bottom plates are used for different styles of containers. The bottom plate provides an identification to a sensor associated with a lower base for communicating a signal to the controller. By selecting the appropriate bottom plate and installing it on the lower base, a signal is generated and sent to the controller indicative of the type of container loaded into the mixing apparatus. The controller retrieves an appropriate algorithm or routine from its memory and imposes the appropriate clamping force by way of an upper plate that is lowered down into clamping engagement with a container or containers. Thus, one mixer can be used for a variety of different types, styles and sizes of containers.

    Automated clamping control mechanism and clamping method for fluid mixers
    83.
    发明申请
    Automated clamping control mechanism and clamping method for fluid mixers 有权
    流体混合器自动夹紧控制机构和夹紧方法

    公开(公告)号：US20070211568A1

    公开(公告)日：2007-09-13

    申请号：US11372306

    申请日：2006-03-09

    Applicant: Margaret Lowan ,  Steven Page

    Inventor： Margaret Lowan ,  Steven Page

    IPC: B01F11/00

    CPC classification number: B01F11/0025 ,  B01F15/00253 ,  B01F15/00753 ,  B01F2215/005 ,  Y10S366/601 ,  Y10S366/605

    Abstract: Disclosed herein is a system and method for adequately securing the currently available metal and plastic containers for paint and other fluids as well as other foreseeable containers in an automated fashion without crushing or damaging the containers, without using any special adapters for particular container types and without operator intervention. To avoid crushing a plastic container, the disclosed system and method takes advantage of the compressibility of these less rigid plastic containers. It has been found that a plastic paint container can be safely clamped in place without structural damage if the clamp plate travel after engagement with the top of the container is limited to a certain value, for example, about 5/16″. When the compression amount if limited or controlled, the plastic container will not move or will move very little during a three minute violent shake cycle. Some conventional containers are not readily compressible, such a metal cans, drums or the larger (five gal.) plastic buckets or pails. To address the issue of these containers being used with the same machine as the new plastic containers, an increase in current or voltage drawn by the clamping motor is monitored after initial contact with the top(s) of the container(s), and if the increase reaches a threshold value, the motion of the upper clamping plate is stopped and an appropriate holding force is maintained.

    Abstract translation: 本文公开了一种系统和方法，用于以自动方式充分固定用于油漆和其它流体的当前可用的金属和塑料容器以及其它可预见的容器，而不会破坏或损坏容器，而不使用用于特定容器类型的任何特殊适配器， 操作员干预。 为了避免破碎塑料容器，所公开的系统和方法利用了这些较不刚性的塑料容器的可压缩性。 已经发现，如果在与容器的顶部接合之后夹紧板行进的塑料涂料容器被限制到一定值，例如约5/16“，则可以将塑料涂料容器安全地夹紧就位而没有结构损坏。 当压缩量受到限制或受控时，塑料容器在三分钟的剧烈抖动周期内不会移动或移动很少。 一些常规容器不容易压缩，例如金属罐，桶或更大的（5加仑）塑料桶或桶。 为了解决与新塑料容器相同的机器使用的这些容器的问题，在与容器的顶部初始接触之后监测由夹紧电机牵引的电流或电压的增加，并且如果 增加达到阈值，停止上夹持板的运动并保持适当的保持力。

    Enhanced thawing of biopharmaceutical solutions using oscillatory motion
    84.
    发明申请
    Enhanced thawing of biopharmaceutical solutions using oscillatory motion 审中-公开
    使用振荡运动增强生物药物溶液的解冻

    公开(公告)号：US20060032607A1

    公开(公告)日：2006-02-16

    申请号：US11252926

    申请日：2005-10-18

    Applicant: Richard Wisniewski

    Inventor： Richard Wisniewski

    IPC: F24H3/00

    CPC classification number: A61M1/025 ,  A61M1/0254 ,  A61M5/445 ,  B01F11/0022 ,  B01F11/0025 ,  B01F11/0082 ,  B01F11/0094 ,  B01F11/04 ,  B01F15/00915 ,  B01F15/065 ,  B01F2015/062

    Abstract: Disclosed are methods for thawing frozen biopharmaceutical solutions including providing a container that contains a biopharmaceutical solution, at least a portion of the biopharmaceutical solution being frozen, providing an oscillatory driver coupled to the biopharmaceutical solution; providing a heat flux into the biopharmaceutical solution; and inducing oscillatory motion of the biopharmaceutical solution via oscillatory motion of the oscillatory driver to accelerate thawing, compared to motionless thawing, of the portion of the biopharmaceutical solution that is frozen. Also disclosed are devices for thawing frozen biopharmaceutical solutions.

    Abstract translation: 公开了用于解冻冷冻生物药物溶液的方法，包括提供包含生物药物溶液的容器，至少部分生物药物溶液被冷冻，提供耦合到生物药物溶液的振荡驱动器; 向生物药物溶液提供热通量; 并且通过所述振荡驱动器的振荡运动来诱导所述生物药物溶液的振荡运动，以相对于被冻结的所述生物药物溶液的部分的静态解冻来加速解冻。 还公开了用于解冻冷冻生物药物溶液的装置。

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