公开(公告)号：US20190380833A1

公开(公告)日：2019-12-19

申请号：US16554014

申请日：2019-08-28

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a frame, a valvular structure coupled to the frame, and a sealing member coupled to the frame. The frame has inflow and outflow ends and a lumen extending therebetween. The frame includes struts that form cells, and the cells are arranged in three rows. The frame is radially expandable from a collapsed state to an expanded state. The valvular structure includes a plurality of leaflets configured to allow blood flow through the lumen of the frame from the inflow end to the outflow end and to block blood flow through the lumen of the frame from the outflow end to the inflow end. The sealing skirt extends from an intermediate location of the frame disposed between the inflow and outflow ends to the inflow end of the frame. The sealing skirt covers two rows of cells to block blood flow through the cells.

公开(公告)号：US10433958B2

公开(公告)日：2019-10-08

申请号：US16201800

申请日：2018-11-27

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US10363132B2

公开(公告)日：2019-07-30

申请号：US15697740

申请日：2017-09-07

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolay Gurovich ,  Elena Sherman

IPC: A61F2/24

Abstract: A prosthetic heart valve can comprise a radially collapsible and expandable annular frame and a leaflet structure comprising a plurality of leaflets mounted within the frame. The frame can have commissure attachment portions that are configured to support the commissures of the leaflets in unique ways. For example, commissure attachment portions can include at least two struts defining a gap therebetween. Additionally, angularly-spaced commissure attachment portions can comprise inner struts and outer struts. Adjacent side portions of leaflets can extend through a gap between the inner struts of a corresponding commissure attachment portion. Further features and arrangements are also possible.

公开(公告)号：US20190076244A1

公开(公告)日：2019-03-14

申请号：US16121947

申请日：2018-09-05

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  David Maimon ,  Michael G. Valdez ,  Tram Ngoc Nguyen

IPC: A61F2/24

Abstract: An implantable prosthetic valve can include an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration. A leaflet structure can be positioned within the frame and secured thereto. An annular sealing member can be positioned around an outer surface of the frame, wherein the sealing member has a periodic, undulating shape. An outer skirt can be positioned around an outer surface of the sealing member and secured to the frame.

公开(公告)号：US20180325665A1

公开(公告)日：2018-11-15

申请号：US15978459

申请日：2018-05-14

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Alexey M. Tsypenyuk ,  Elena Sherman ,  Dikla Kersh ,  Boaz Manash ,  Liron Tayeb ,  Ziv Yohanan ,  Alexander Barash ,  Yair A. Neumann ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2230/0069

Abstract: A prosthetic heart valve includes an annular frame including a plurality of strut members that is radially collapsible and expandable. A leaflet structure is situated within the frame, and includes a plurality of leaflets having opposing commissure tab portions on opposite sides of the leaflet. Each commissure tab portion is paired with an adjacent commissure tab portion of an adjacent leaflet to form one or more commissures. A commissure support element is positioned at each of the commissures, and comprise a first member and a second member that are separable from each other and configured to receive leaflets therebetween. The first and second members are detached from the frame and spaced radially inwardly from the frame such that the members contact the leaflets radially inward from the frame and limit movement of the leaflets so that they articulate at a location that is spaced radially inwardly from the frame.

公开(公告)号：US20180318074A1

公开(公告)日：2018-11-08

申请号：US16039215

申请日：2018-07-18

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a frame, a valve member, and a sealing member. The frame is expandable from a collapsed state to an expanded state. The frame has inflow and outflow ends, a lumen extending between the ends, and a plurality of struts defining a plurality of cells. The valve member is disposed within the lumen of the frame and is movable between open and closed configurations. The sealing member is mounted inside of the frame. When the frame is in the expanded state and the valve member is in the closed configuration, portions of the sealing member can protrude outwardly through the cells of the frame and extend beyond an exterior surface of the struts of the frame.

公开(公告)号：US10076411B2

公开(公告)日：2018-09-18

申请号：US15246234

申请日：2016-08-24

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

Abstract: The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

公开(公告)号：US20180153689A1

公开(公告)日：2018-06-07

申请号：US15831197

申请日：2017-12-04

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Boaz Manash ,  Eyal Leiba ,  Ziv Yohanan ,  Yair A. Neumann ,  Anatoly Dvorsky ,  Jonathan Bar-Or ,  Oren Cohen ,  Ofir Witzman ,  Liron Tayeb ,  Elazar Levi Schwarcz ,  Noam Miller ,  Tomer Saar

IPC: A61F2/24

Abstract: An assembly can comprise a radially expandable and compressible annular frame, at least one linear actuator assembly coupled to the frame and at least one locking mechanism coupled to the frame. The linear actuator can be configured to apply a distally directed force and/or a proximally directed force to the frame to radially expand or compress the frame. The locking mechanism can comprise a first sleeve member connected to the frame at a first location, a second sleeve member having internal threads and being connected to the frame at a second location, and a first screw configured to engage the internal threads of the second sleeve member to retain the frame in a radially expanded state.

公开(公告)号：US20180028310A1

公开(公告)日：2018-02-01

申请号：US15664430

申请日：2017-07-31

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey M. Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24

Abstract: A prosthetic heart valve can include a radially collapsible and expandable annular frame having a plurality of struts defining openings. The prosthetic heart valve can further include a plurality of leaflets that regulate the flow of blood through the frame. The prosthetic heart valve can also include a sealing member mounted on the frame and having an inner layer and an outer layer. At least the outer layer is mounted on the outside of the frame, and the inner layer covers at least the openings in the frame between adjacent cusp portions of adjacent leaflets and the inner layer does not cover one or more openings in the frame at locations facing the outflow surfaces of the leaflets to permit retrograde blood to flow through the one or more uncovered openings in the frame and into space between the outer layer and the frame.

公开(公告)号：US12226312B2

公开(公告)日：2025-02-18

申请号：US18316942

申请日：2023-05-12

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24 ,  A61F2/90

Abstract: A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end, an outflow end, and a plurality of struts. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a coaptation edge portion and a cusp edge portion. The cusp edge portion of each leaflet can be folded toward the outflow end of the frame along a bending axis and a reinforcing member extends along an outflow surface of the cusp edge portion along the bending axis. The prosthetic heart valve can include a plurality of connecting skirts, each disposed between the cusp edge portion of an adjacent leaflet and the frame. First stitching secures the reinforcing member and the connecting skirts to the cusp edge portions and second stitching secures the connecting skirts to selected struts of the frame.