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公开(公告)号：US11674159B2
公开(公告)日：2023-06-13
申请号：US17220692
申请日：2021-04-01
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12N9/22 , C12N15/113 , C12N15/10 , A61K38/46 , C12Q1/686 , H01L21/205 , H01L33/00 , H01L21/02 , C12N15/70 , C12N15/74 , A01H6/46 , A01K67/027 , A61K48/00
CPC分类号： C12N15/907 , A01H6/4684 , A01K67/027 , A61K38/465 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/746 , C12N15/90 , C12N15/902 , C12Q1/686 , H01L21/02312 , H01L21/205 , H01L33/0075 , A61K48/00 , C12N2310/11 , C12N2310/13 , C12N2310/14 , C12N2310/20 , C12N2310/31 , C12N2310/32 , C12N2310/33 , C12N2310/3519 , C12N2310/531 , C12N2800/80 , C12Y301/04
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US11634730B2
公开(公告)日：2023-04-25
申请号：US16385383
申请日：2019-04-16
IPC分类号： C12N15/10 , A61K38/46 , C12N15/11 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/90 , C12Q1/686 , C12N9/22 , A01H6/46 , A01K67/027 , H01L21/205 , H01L33/00 , H01L21/02 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US11549127B2
公开(公告)日：2023-01-10
申请号：US17703849
申请日：2022-03-24
IPC分类号： C12N15/10 , A61K38/46 , C12N15/11 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/90 , C12Q1/686 , C12N9/22 , A01H6/46 , A01K67/027 , H01L21/205 , H01L33/00 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220267807A1
公开(公告)日：2022-08-25
申请号：US17559860
申请日：2021-12-22
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220119847A1
公开(公告)日：2022-04-21
申请号：US17514929
申请日：2021-10-29
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220112521A1
公开(公告)日：2022-04-14
申请号：US17514940
申请日：2021-10-29
IPC分类号： C12N15/90 , A01K67/027 , C12N15/63 , C12N15/70 , C12N15/74 , C12N9/22 , C12Q1/686 , A01H6/46 , C12N15/113 , C12N15/10 , C12N15/11 , A61K38/46 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US11274318B2
公开(公告)日：2022-03-15
申请号：US17326818
申请日：2021-05-21
IPC分类号： C12N15/11 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/90 , C12N15/63 , C12Q1/686 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220025407A1
公开(公告)日：2022-01-27
申请号：US17481085
申请日：2021-09-21
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210388395A1
公开(公告)日：2021-12-16
申请号：US17348619
申请日：2021-06-15
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210332391A1
公开(公告)日：2021-10-28
申请号：US17326818
申请日：2021-05-21
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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