公开(公告)号：US11185532B2

公开(公告)日：2021-11-30

申请号：US16864400

申请日：2020-05-01

申请人： Clexio Biosciences Ltd.

发明人： Yael Rosen ,  David Dangoor ,  Richard Fisher

IPC分类号： A61K31/4164 ,  A61P17/04 ,  A61K31/4174 ,  A61K9/00 ,  A61K45/06

摘要： The present disclosure related to methods of treating pruritus in a subject by topically administering detomidine, or a pharmaceutically acceptable salt thereof, to the subject.

公开(公告)号：US20210228505A1

公开(公告)日：2021-07-29

申请号：US17229623

申请日：2021-04-13

申请人： Clexio Biosciences Ltd.

发明人： Elena Kagan ,  Gina Pastino

IPC分类号： A61K31/135 ,  A61K9/00 ,  A61K9/16 ,  A61K31/15 ,  A61K31/136 ,  A61K31/36 ,  A61K31/343 ,  A61K31/7034 ,  A61K31/381

摘要： The present invention provides a method for safe and efficacious administration of esketamine.

公开(公告)号：US20210113494A1

公开(公告)日：2021-04-22

申请号：US17136634

申请日：2020-12-29

申请人： Clexio Biosciences Ltd.

发明人： Elena Kagan ,  Gina Pastino ,  Esther Lukasiewicz-Hagai ,  Ari Gershon

IPC分类号： A61K31/135 ,  A61P25/18 ,  A61K31/138 ,  A61K31/4525 ,  A61K31/343 ,  A61K31/137 ,  A61K31/381 ,  A61K31/15 ,  A61K9/00

摘要： The present disclosure provides methods for safe and efficacious administration of esketamine.

公开(公告)号：US10888528B2

公开(公告)日：2021-01-12

申请号：US16241102

申请日：2019-01-07

申请人： Clexio Biosciences Ltd.

发明人： Dinesh K. Haswani ,  Derek V. Moe ,  Victoria A. O'Neill ,  Randal A. Seburg ,  Manuel A. Vega Zepeda

IPC分类号： A61K9/50 ,  A61K9/28 ,  A61K45/06 ,  A61K31/4458 ,  A61K47/58 ,  A61K31/00 ,  A61K9/20 ,  A61K31/136 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/437 ,  A61K31/485 ,  A61K31/515 ,  A61K31/5513 ,  A61K31/554 ,  A61K47/61 ,  A61K47/54 ,  A61K47/59 ,  A61K9/00 ,  A61K31/135

摘要： Described are immediate release oral dosage forms that contain abuse-deterrent features. In particular, the disclosed dosage forms provide deterrence of abuse by ingestion of multiple individual doses. In addition, the disclosed dosage forms provide protection from overdose in the event of accidental or intentional ingestion of multiple individual doses.

公开(公告)号：US20200000748A1

公开(公告)日：2020-01-02

申请号：US16454399

申请日：2019-06-27

申请人： Clexio Biosciences Ltd.

发明人： Elena Kagan ,  Petra Luise Goelzer

IPC分类号： A61K31/136 ,  A61P25/24

摘要： The present invention provides a method for safe and efficacious administration of esketamine.

公开(公告)号：US10195143B2

公开(公告)日：2019-02-05

申请号：US15368274

申请日：2016-12-02

申请人： Clexio Biosciences Ltd.

发明人： Ilan Zalit ,  Avshalom Ben Menachem

IPC分类号： A61K9/00 ,  A61K9/48 ,  A61J3/07

摘要： The present disclosure provides a device for self-preparation of a gastroretentive dosage form being capable of transitioning between a collapsed configuration and an expanded configuration, the device comprising an assembly unit including: a compartment configured for accommodating the gastroretentive dosage form in the expanded configuration; and a mechanical system configured for, upon operation of an actuation mechanism: (a) transitioning said gastroretentive dosage form into the collapsed configuration; and (b) locking said collapsed gastroretentive dosage form into the collapsed configuration; wherein the device is configured for being portable.