公开(公告)号：US20210106673A1

公开(公告)日：2021-04-15

申请号：US17078704

申请日：2020-10-23

申请人： VIB VZW ,  Universiteit Gent

发明人： Xavier Saelens ,  Bert Schepens ,  Walter Fiers

IPC分类号： A61K39/155 ,  A61K39/12 ,  C12N7/02 ,  A61K39/385 ,  C07K16/10 ,  C07K7/06 ,  C07K14/005 ,  C07K14/78 ,  C12N7/00

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

公开(公告)号：US10946070B2

公开(公告)日：2021-03-16

申请号：US16020447

申请日：2018-06-27

申请人： Vib Vzw ,  Universiteit Gent ,  Centre National de la Recherche Scientifique ,  UNIVERSITÉ DE MONTPELLIER ,  Centre Hospitalier Regional Universitaire de Montpellier ,  Universitat Osnabruck

发明人： Jan Tavernier ,  Gilles Uzé ,  Guillaume Cartron ,  Franciane Paul ,  Jacob Piehler

IPC分类号： A61K38/21 ,  C07K14/56 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68

摘要： This disclosure relates to a modified α-helical bundle cytokine, with reduced activity via an α-helical bundle cytokine receptor, wherein the α-helical bundle cytokine is specifically delivered to target cells. Preferably, the α-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified α-helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified α-helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.

公开(公告)号：US20210030780A1

公开(公告)日：2021-02-04

申请号：US16964149

申请日：2019-01-28

申请人： Universiteit Gent ,  VIB VZW

发明人： Elisabeth Van Aken ,  Joris Delanghe ,  Nico Callewaert ,  Loes Van Schie

IPC分类号： A61K31/7076 ,  A61K33/06 ,  A61K38/45

摘要： A non-surgical treatment of cataract in a human or animal. The invention specifically relates to the administration of a deglycating enzyme and its cofactor(s), which results in the deglycation of the lens crystallins. The disclosure thus relates to a minimal invasive type of treatment of cataract, which is easier and cheaper compared to existing surgical methods.

公开(公告)号：US20210015921A1

公开(公告)日：2021-01-21

申请号：US16965876

申请日：2019-01-24

申请人： Universiteit Gent

发明人： Dries Rombaut ,  Pieter Mestdagh ,  Steve Lefever

IPC分类号： A61K45/06 ,  A61P35/00 ,  G01N33/49 ,  C12N15/113 ,  C12Q1/6886

摘要： A treatment of cancer, particularly the treatment of neuroblastoma. Indeed, the discloses that a particular long non-coding RNA (lncRNA) is specifically up-regulated in neuroblastoma cells as compared to other cancer cells and that high expression of the lncRNA correlates with a lower survival probability. Inhibition of this lncRNA in neuroblastoma cells leads to a reduction in cell growth and induction of apoptosis and is a novel therapeutic strategy in the treatment of neuroblastoma.

公开(公告)号：US20200335482A1

公开(公告)日：2020-10-22

申请号：US16764011

申请日：2018-11-12

申请人： BARCO N.V. ,  IMEC VZW ,  UNIVERSITEIT GENT

发明人： Saso MLADENOVSKI ,  Jasper Irene LAMBERT ,  Stephanie Cyriel Adrianna VAN HAECKE ,  Floris Albert BONTINCK ,  Jindrich WINDELS ,  Michal JABLONSKI

IPC分类号： H01L25/075 ,  H01L33/60 ,  H01L27/32 ,  H01L33/52 ,  H01L33/00

摘要： An LED array mounted on a circuit board including a plurality of LED chips embedded in an encapsulant. Each LED chip is placed inside a cavity which is made up solely from a multilayer foil and attached to the circuit board with an adhesive film. The foil cavity design enables a variety of mounted LED arrays to be manufactured with the same process.

公开(公告)号：US20200305428A1

公开(公告)日：2020-10-01

申请号：US16954976

申请日：2018-12-20

申请人： UNIVERSITEIT GENT ,  VIB VZW ,  TAMINCO BVBA

发明人： Willem Desmedt ,  Tina Kyndt ,  Bartel Vanholme

IPC分类号： A01N43/40 ,  A01N43/30 ,  A01N37/10 ,  A01N37/40

摘要： The present invention is in the field of agricultural pathogen control. More specifically the invention relates to compounds capable of inhibiting cinnamate-4-hydroxylase and their use for protecting plants against plant pathogens, in particular against nematodes, fungi and/or bacteria. The invention also provides for compositions comprising the same, methods of making the same, and methods of controlling plant disease.

公开(公告)号：US10753944B2

公开(公告)日：2020-08-25

申请号：US16081030

申请日：2017-03-01

申请人： UNIVERSITEIT GENT

发明人： Annemieke Madder ,  Christophe Ampe ,  Willem Vannecke ,  Marleen Van Troys

IPC分类号： A61K38/00 ,  G01N33/68

摘要： The present invention relates to a method for covalently binding a cell surface protein and a ligand, the ligand being capable of specifically binding to the cell surface protein, the method consisting essentially of contacting the living cells expressing the cell surface protein with the ligand comprising at least one furan moiety, thereby covalently binding the cell surface protein and the ligand.

公开(公告)号：US10666737B2

公开(公告)日：2020-05-26

申请号：US14655509

申请日：2013-12-27

申请人： Koninklijke KPN N.V. ,  IMEC VZW ,  Universiteit Gent

发明人： Floris Van Den Abeele ,  Jeroen Hoebeke ,  Girum Teklemariam

IPC分类号： H04L29/08

摘要： A method for an intermediary node to reduce a number of server-client sessions between a server (104) and a plurality of clients (102a, 102b, 102c) communicably connected to the server (104) over a network is disclosed. The intermediary node (106) intercepts a first request and a second request destined to the server (104) from a first client (102a; 102b; 102c) and a second client (102a; 102b; 102c). The intermediary node (106) establishes a server-client session, between the intermediary node (106) and the server (104), using the first request. If the first request overlaps in part with the second request and if a part of the second request is not overlapping with the first request, the intermediary node (106) updates the server-client session between the intermediary node (106) and the server (104) to include a part of the second request.

公开(公告)号：US20200157274A1

公开(公告)日：2020-05-21

申请号：US16751752

申请日：2020-01-24

申请人： Universiteit Gent ,  Allnex Beligum SA

发明人： Peter Dubruel ,  Sandra Van Vlierberghe ,  Annemie Houben ,  Hugues Van Den Bergen ,  Patrice Roose ,  Dirk Bontinck

IPC分类号： C08G18/75 ,  C08J3/24 ,  D01F11/08 ,  D01D5/00 ,  C09D175/16 ,  C08J3/28 ,  C08G18/10 ,  C08G18/42 ,  C08G18/48 ,  C08G18/67

摘要： The invention pertains to the technical field of urethane based materials, in particular to radiation curable urethane precursors that are cross-linkable in solid form and materials obtainable therefrom. In addition the invention pertains to methods for manufacturing these precursors and materials, and their uses. The invention is advantageous to the fields of i.e. coatings and biomedical applications.

公开(公告)号：US10581703B2

公开(公告)日：2020-03-03

申请号：US15538188

申请日：2015-12-17

申请人： KONINKLIJKE KPN N.V. ,  NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO ,  IMEC VZW ,  UNIVERSITEIT GENT

发明人： Rudolf Strijkers ,  Shuang Zhang ,  Jeroen Famaey ,  Niels Bouten

IPC分类号： G06F15/16 ,  H04L12/24 ,  G06F9/50 ,  G06F9/455

摘要： The disclosure relates to a computer-implemented method for controlling on-demand service provisioning in a network, wherein the network comprises resources for providing a service. In the method, a service request is intercepted. At least one network function, indicated as a first network function, required for the service associated with the service request is determined. Then, the first network function is instantiated on a resource in the network for executing the service in the network.