公开(公告)号：US20090240154A1

公开(公告)日：2009-09-24

申请号：US12476294

申请日：2009-06-02

Applicant: Oliver Meissner ,  Martin Ostermeier ,  Martin Hoheisel

Inventor： Oliver Meissner ,  Martin Ostermeier ,  Martin Hoheisel

IPC: A61N5/06 ,  A61B6/00

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/0084 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0609

Abstract: In a catheter device and a method for in vivo activation of a photosensitizing drug in a vessel, endovascular tissue, and/or intraluminal tissue, a catheter carrying both an optical coherence tomography (OCT) lens, from which OCT imaging light is emitted, and a photodynamic therapy (PDT) lens from which photosensitizing drug-activating light is emitted, is inserted into a vessel containing a lesion to be treated. A photosensitizing drug is caused to be placed in the vessel as well, such as in the form of a coating on a stent or a coating on an exterior of a balloon carried by the catheter. Light is emitted from the PDT lens to activate the photosensitizing drug while light is simultaneously emitted from the OCT lens to obtain an OCT image to monitor the drug activation.

Abstract translation: 在导管装置和用于体内活化容器，血管内组织和/或管腔内组织中的光敏药物的方法中，携带OCT成像光的光学相干断层摄影（OCT）透镜的导管以及 将光敏感药物激活光发射的光动力疗法（PDT）镜片插入含有待治疗病变的容器中。 导致光敏药物也被放置在容器中，例如以支架的形式或由导管承载的球囊的外部上的涂层的形式。 光从PDT透镜发射以激活光敏药物，同时从OCT镜片同时发出光，以获得OCT图像以监测药物激活。

公开(公告)号：US20090149740A1

公开(公告)日：2009-06-11

申请号：US12313567

申请日：2008-11-21

Applicant: Martin Hoheisel

Inventor： Martin Hoheisel

IPC: A61B5/05

CPC classification number: A61B19/5244 ,  A61B34/20 ,  A61B90/06 ,  A61B2017/00694 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2090/064 ,  A61B2090/0818 ,  A61B2090/364

Abstract: The invention relates to a device for a medical intervention in or on moving tissue of a living being, said device having a medical instrument provided for the intervention, a position detection system by means of which the position of the medical instrument in the body of the living being can be determined, and at least one acceleration sensor for recording at least one movement of the instrument caused by the moving tissue. The invention also relates to a medical instrument for a medical intervention in or on moving tissue of a living being, said medical instrument having at least one acceleration sensor and a sensor of a position detection system, as well as to an operating method for the device.

Abstract translation: 本发明涉及一种用于在活体内或移动组织上进行医疗干预的装置，所述装置具有用于干预的医疗器具，位置检测系统，通过该位置检测系统，医疗器械在身体中的位置 可以确定生物体，以及至少一个加速度传感器，用于记录由移动组织引起的仪器的至少一个运动。 本发明还涉及一种医疗器械，用于医疗介入在活体的移动组织中或其上，所述医疗器具具有至少一个加速度传感器和位置检测系统的传感器，以及该装置的操作方法 。

公开(公告)号：US20090074139A1

公开(公告)日：2009-03-19

申请号：US12222077

申请日：2008-08-01

Applicant: Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

Inventor： Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

IPC: G01N23/04 ,  A61B6/03

CPC classification number: A61B6/032 ,  A61B5/14532 ,  A61B6/484 ,  G21K2207/005

Abstract: A method and an x-ray system are disclosed for detecting and localizing a metabolic marker. In at least one embodiment, the method includes creating at least one absorption x-ray view of a patient or of a first region of a patient; creating at least one phase-contrast x-ray view of the patient or of a second region of the patient, with a quasi-coherent x-ray radiation being generated for the phase-contrast measurement with the aid of an x-ray grating arranged between the x-ray source and the patient, and the spatially dependent phase shift of the x-ray radiation in the patient being made visible with the aid of at least one grating between the patient and a detector; superposing the at least one absorption x-ray view and the at least one phase-contrast x-ray view; wherein orientation based on anatomical features is carried out with the aid of the at least one absorption x-ray view, and a spatial distribution of the metabolic marker present in the body of the patient is determined by the at least one phase-contrast x-ray view.

Abstract translation: 公开了用于检测和定位代谢标记物的方法和x射线系统。 在至少一个实施例中，该方法包括创建患者或患者的第一区域的至少一个吸收x射线视图; 产生患者或患者的第二区域的至少一个相差x射线图，其中准相干X射线辐射是借助于布置在所述X射线光栅上的相位对比度测量来产生的 在x射线源和患者之间，借助于患者和检测器之间的至少一个光栅使患者中的x射线辐射的空间相关相移变得可见; 叠加所述至少一个吸收x射线视图和所述至少一个相差x射线视图; 其中基于解剖特征的取向借助于所述至少一个吸收x射线视图进行，并且存在于患者体内的代谢标记的空间分布由所述至少一个相位对比度x射线确定， ray视图。

公开(公告)号：US20090052614A1

公开(公告)日：2009-02-26

申请号：US12222505

申请日：2008-08-11

Applicant: Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

Inventor： Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

IPC: A61B6/00 ,  A61B5/05

CPC classification number: A61B6/12 ,  A61B6/4291 ,  A61B6/484 ,  A61F2/82 ,  A61F2250/0032 ,  A61F2250/0098 ,  A61L27/50 ,  A61L31/18 ,  G21K2207/005

Abstract: A method is disclosed for marking and visualizing an implant by use of an x-ray phase-contrast tomography examination. Further, an implant is also disclosed. In at least one embodiment, implants are used with specific characteristics which are as unambiguous as possible with regard to the phase shift generated by the implants in a phase-contrast tomography examination. In at least one embodiment, these specific characteristics can include the typical self-generated specific phase shift, typical differences in the specific phase-shift values, or typical spatial structures of materials with well-defined phase-shift values.

Abstract translation: 公开了一种通过使用X射线相位层析成像检查对植入物进行标记和可视化的方法。 此外，还公开了一种植入物。 在至少一个实施例中，使用具有特定特征的植入物，其相对于相位层析成像检查中由植入物产生的相移尽可能不含糊。 在至少一个实施例中，这些特定特征可以包括典型的自发特定相移，特定相移值中的典型差异或具有明确定义的相移值的材料的典型空间结构。

公开(公告)号：US20090052611A1

公开(公告)日：2009-02-26

申请号：US12222349

申请日：2008-08-07

Applicant: Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

Inventor： Eckhard Hempel ,  Martin Hoheisel ,  Stefan Popescu ,  Rainer Raupach

IPC: A61B6/00

CPC classification number: A61B6/032 ,  A61B6/037 ,  A61B6/484 ,  A61B6/503 ,  A61B6/507

Abstract: A method and an x-ray computed tomography system are disclosed for visualizing at least two different types of cardiac tissue, such as normally perfused tissue, hypoperfused tissue and scarred tissue. In at least one embodiment, this is done by use of an imaging tomographic recording technique with the aid of x-ray radiation, wherein at least one cardiac region of a patient is scanned by x-ray radiation which passes through a first grating for the passing-through x-ray radiation, designed as an absorption grating, prior to reaching the patient, and at least the locally caused phase-shifts of the x-ray radiation in the cardiac region are also made detectable by using a second grating for the passing-through x-ray radiation, designed as a phase grating, downstream of the patient in the emission direction, and the spatial distribution of these shifts is measured and reconstructed, wherein an average specific phase-shift value is assigned to each spatial unit, wherein each of the abovementioned tissue types are assigned to a region of a typical specific phase-shift value and at least one region assigned to a tissue type is optically highlighted in a view of the cardiac region.

Abstract translation: 公开了一种方法和x射线计算机断层摄影系统，用于可视化至少两种不同类型的心脏组织，例如通常灌注的组织，低灌注组织和瘢痕组织。 在至少一个实施例中，这通过使用借助于X射线辐射的成像断层摄影记录技术来完成，其中患者的至少一个心脏区域被x射线辐射扫描，X射线辐射通过第一光栅 在到达患者之前设计为吸收光栅的穿透X射线辐射以及至少在心脏区域中的x射线辐射的局部引起的相移也可以通过使用第二光栅来检测 测量并重构这些偏移的空间分布，其中平均特定相移值被分配给每个空间单元，其中， 其中上述组织类型中的每一种被分配给典型的特定相移值的区域，并且指定为组织类型的至少一个区域在心脏区域的视图中被光学突出显示。

公开(公告)号：US07486770B2

公开(公告)日：2009-02-03

申请号：US11700172

申请日：2007-01-31

Applicant: Joachim Baumann ,  Christian David ,  Martin Engelhardt ,  Jorg Freudenberger ,  Eckhard Hempel ,  Martin Hoheisel ,  Thomas Mertelmeier ,  Franz Pfeiffer ,  Stefan Popescu ,  Manfred Schuster

Inventor： Joachim Baumann ,  Christian David ,  Martin Engelhardt ,  Jorg Freudenberger ,  Eckhard Hempel ,  Martin Hoheisel ,  Thomas Mertelmeier ,  Franz Pfeiffer ,  Stefan Popescu ,  Manfred Schuster

IPC: G01N23/04

CPC classification number: G21K1/06 ,  A61B6/032 ,  A61B6/06 ,  A61B6/4092 ,  A61B6/4233 ,  A61B6/4291 ,  A61B6/484 ,  G21K2207/005

Abstract: A focus-detector arrangement includes a radiation source with a focus, arranged on a first side of the subject, for generating a fan-shaped or conical beam of rays; at least one X-ray optical grating arranged in the beam path, with at least one phase grating arranged on the opposite second side of the subject in the beam path generating an interference pattern of the X-radiation preferably, in a particular energy range; and an analysis-detector system which detects at least the interference pattern generated by the phase grating in respect of its phase shift with position resolution. According to at least one embodiment of the invention, at least one X-ray optical grating including bars which are free from overhangs form shadows in the beam path of the fan-shaped or conical beam of rays.

Abstract translation: 焦点检测器装置包括布置在被摄体的第一侧上的具有焦点的辐射源，用于产生扇形或锥形的射线束; 布置在所述光束路径中的至少一个X射线光栅，其中至少一个相位光栅布置在所述束路径中的所述对象的相对的第二侧上，优选地在特定能量范围内产生所述X射线的干涉图案; 以及分析检测器系统，其至少检测相位光栅相对于其相移与位置分辨率产生的干涉图案。 根据本发明的至少一个实施例，至少一个X射线光栅，其包括不具有突出端的杆，在扇形或锥形光束的光束路径中形成阴影。

公开(公告)号：US07298882B2

公开(公告)日：2007-11-20

申请号：US11058025

申请日：2005-02-15

Applicant: Philipp Bernhardt ,  Lothar Bätz ,  Ernst-Peter Rührnschopf ,  Martin Hoheisel

Inventor： Philipp Bernhardt ,  Lothar Bätz ,  Ernst-Peter Rührnschopf ,  Martin Hoheisel

IPC: G06T5/00

CPC classification number: G06T7/0002 ,  A61B5/02007 ,  A61B5/7257 ,  A61B6/12 ,  A61B6/4291

Abstract: A method for defining image quality characteristics of X-ray based medical projection imaging devices is provided. A spatial frequency-dependent signal-to-noise ratio function includes image quality parameters of spatial resolution, object contrast and noise. The detectability of an object embedded into a defined background, such as a cardiac guide wire in a patient is determined. An X-ray system may be defined and set up for obtaining an optimized image quality to determine the best object detectability for a given patient dose.

Abstract translation: 提供了一种用于定义基于X射线的医疗投影成像装置的图像质量特性的方法。 空间频率相关信噪比函数包括空间分辨率，对象对比度和噪声的图像质量参数。 确定嵌入到定义的背景中的对象的可检测性，例如患者中的心导丝。 可以定义和设置X射线系统以获得优化的图像质量，以确定给定患者剂量的最佳对象检测能力。

公开(公告)号：US07209547B2

公开(公告)日：2007-04-24

申请号：US10970605

申请日：2004-10-21

Applicant: Florian Baier ,  Martin Hoheisel

Inventor： Florian Baier ,  Martin Hoheisel

IPC: G21K1/02

CPC classification number: A61B6/032 ,  A61B6/06 ,  A61B6/4085 ,  A61N5/1042 ,  B33Y80/00 ,  G21K1/025 ,  G21K1/04

Abstract: An apparatus for spatial modulation of an x-ray beam has a number of planar attenuation elements for x-ray radiation that are disposed in a grid on a carrier and can be pivoted or tilted by a piezoelectric actuator, independently of one another, between at least two positions. One or more sensors with which a piezoelectrically-caused length and/or width and/or position change of the piezoelectrically influenced regions can be detected, are arranged on piezoelectrically influenced regions of the attenuation elements or the actuators. A significant dose reduction and/or dynamic adjustment thereof can be achieved with the apparatus by image adaptation in many areas of x-ray imaging, since a precise determination of the position of each attenuation element in real time is enabled.

Abstract translation: 用于x射线束的空间调制的装置具有多个用于x射线辐射的平面衰减元件，其被布置在载体上的栅格中，并且可以彼此独立地由压电致动器枢转或倾斜，处于 至少两个职位。 能够检测压电影响区域的压电引起的长度和/或宽度和/或位置变化的一个或多个传感器被布置在衰减元件或致动器的压电影响区域上。 由于能够实时精确地确定每个衰减元件的位置，所以可以通过在x射线成像的许多区域中的图像适应来实现该设备的显着剂量减小和/或动态调整。

公开(公告)号：US20070009698A1

公开(公告)日：2007-01-11

申请号：US11481665

申请日：2006-07-06

Applicant: Martin Hoheisel

Inventor： Martin Hoheisel

IPC: B32B33/00

CPC classification number: A61B46/10 ,  A61B90/40 ,  B29C63/0056 ,  Y10T428/14

Abstract: The invention relates to a device for protecting a display facility, comprising a protective element for covering an image surface of the display facility. As the protective element is designed to be transparent and the retaining means are provided for the exchangeable arrangement of the protective element in front of the image surface, a protective device is provided, which allows the image surface to be examined and is easy to operate.

Abstract translation: 本发明涉及一种用于保护显示设备的设备，包括用于覆盖显示设备的图像表面的保护元件。 由于保护元件被设计为透明的并且为图像表面之前的保护元件的可更换布置提供了保持装置，因此提供了保护装置，这允许检查图像表面并且易于操作。

公开(公告)号：US20060182322A1

公开(公告)日：2006-08-17

申请号：US11058025

申请日：2005-02-15

Applicant: Philipp Bernhardt ,  Lothar Batz ,  Ernst-Peter Ruhrnschopf ,  Martin Hoheisel

Inventor： Philipp Bernhardt ,  Lothar Batz ,  Ernst-Peter Ruhrnschopf ,  Martin Hoheisel

IPC: G06K9/00

CPC classification number: G06T7/0002 ,  A61B5/02007 ,  A61B5/7257 ,  A61B6/12 ,  A61B6/4291

Abstract: A method for defining image quality characteristics of X-ray based medical projection imaging devices is provided. A spatial frequency-dependent signal-to-noise ratio function includes image quality parameters of spatial resolution, object contrast and noise. The detectability of an object embedded into a defined background, such as a cardiac guide wire in a patient is determined. An X-ray system may be defined and set up for obtaining an optimized image quality to determine the best object detectability for a given patient dose.

Abstract translation: 提供了一种用于定义基于X射线的医疗投影成像装置的图像质量特性的方法。 空间频率相关信噪比函数包括空间分辨率，对象对比度和噪声的图像质量参数。 确定嵌入到定义的背景中的对象的可检测性，例如患者中的心导丝。 可以定义和设置X射线系统以获得优化的图像质量，以确定给定患者剂量的最佳对象检测能力。