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公开(公告)号：US20110109017A1
公开(公告)日：2011-05-12
申请号：US12690185
申请日：2010-01-20
Applicant: Orhun K. Muratoglu , Stephen H. Spiegelberg
Inventor： Orhun K. Muratoglu , Stephen H. Spiegelberg
IPC: H05B6/00
CPC classification number: B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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Patent Agency Ranking
公开(公告)号：US20080274161A1
公开(公告)日：2008-11-06
申请号：US11419142
申请日：2006-05-18
Applicant: Orhun K. Muratoglu , Gavin J. C. Braithwaite , Jeeyoung Choi , Stephen H. Spiegelberg
Inventor： Orhun K. Muratoglu , Gavin J. C. Braithwaite , Jeeyoung Choi , Stephen H. Spiegelberg
CPC classification number: A61L27/52 , A61L31/145 , B01J13/0065 , B01J13/0069 , B01J13/046
Abstract: The invention provides fabricated hydrogels, hydrogel particles, hydrogel containing compositions, and methods of making the same. The invention also provides methods of implanting, injecting, or administering the hydrogels, hydrogel particles, or the hydrogel containing compositions to treat a subject in need. Methods of crosslinking pre-solidified or pre-gelled hydrogel particles and making crosslinked hydrogels, crosslinked hydrogel particles, and crosslinked hydrogel containing compositions also are disclosed herein.
Abstract translation: 本发明提供制造的水凝胶，水凝胶颗粒，含水凝胶组合物及其制备方法。 本发明还提供了植入，注射或施用水凝胶，水凝胶颗粒或含水凝胶的组合物以治疗有需要的受试者的方法。 交联预固化或预胶凝的水凝胶颗粒和制备交联的水凝胶，交联的水凝胶颗粒和交联的含水凝胶的组合物的交联方法也在本文中公开。
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公开(公告)号：US20080215142A1
公开(公告)日：2008-09-04
申请号：US12041249
申请日：2008-03-03
Applicant: Orhun K. Muratoglu , Stephen H. Spiegelberg
Inventor： Orhun K. Muratoglu , Stephen H. Spiegelberg
CPC classification number: A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L2430/02 , C08J3/226 , C08J3/247 , C08J3/28 , C08J2323/06 , C08J2423/00 , C08K5/1545 , C08K2201/012 , C08L23/06 , C08L2666/02 , C08K5/005
Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
Abstract translation: 本发明涉及制备交联的，氧化稳定的和高度结晶的聚合物材料的方法。 本发明还提供了处理照射交联的含抗氧化剂的聚合物和与其一起使用的材料的方法。
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公开(公告)号：US07304097B2
公开(公告)日：2007-12-04
申请号：US11464872
申请日：2006-08-16
Applicant: Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. McKinley
Inventor： Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. McKinley
CPC classification number: C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
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公开(公告)号：US07235592B2
公开(公告)日：2007-06-26
申请号：US10962975
申请日：2004-10-12
Applicant: Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels Abt
Inventor： Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels Abt
IPC: C08F2/46
CPC classification number: C08J3/28 , C08J2329/04 , Y10S524/916
Abstract: The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.
Abstract translation: 本发明提供了制备具有有利物理性质的共价交联的乙烯基聚合物水凝胶和通过这些方法制备的共价交联的乙烯基聚合物水凝胶组合物的方法，以及包含这种共价交联的乙烯基聚合物水凝胶组合物的制品。 所产生的水凝胶的物理性质可以通过改变受控参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。 根据加工条件，这种共价交联的乙烯基聚合物水凝胶可以制成半透明的，优选透明的或不透明的。 所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联剂的量来增强。
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66.发明授权High modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt 有权熔体下面制备的具有降低的残余自由基浓度的高模量交联聚乙烯公开(公告)号：US07166650B2
公开(公告)日：2007-01-23
申请号：US11030115
申请日：2005-01-07
Applicant: Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. McKinley
Inventor： Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. McKinley
CPC classification number: C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
Abstract translation: 本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。 公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。 本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。 。
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