公开(公告)号：US20230265039A1

公开(公告)日：2023-08-24

申请号：US17107037

申请日：2020-11-24

申请人： WOODWARD BIO CORP.

发明人： Gab Yong KIM ,  Seong Eun LEE

IPC分类号： C07C67/08 ,  C07C277/08 ,  C07C279/14

CPC分类号： C07C67/08 ,  C07C277/08 ,  C07C279/14 ,  C07C2601/14

摘要： Provided are an environmentally-friendly high-efficiency method of manufacturing an ester compound based on an esterification reaction using a salt ion-exchange method and an ester compound manufactured thereby. In the conventional esterification reaction, an ester was produced in low yields due to the hydrolysis (i.e., reverse reaction) caused by water, or it was required to continuously supply hydrochloric acid gas or use thionyl chloride, which is a hazardous material, and thus there were limitations in terms of environmental friendliness or cost. On the other hand, in the present invention, hydrochloric acid gas is continuously supplied using the salt ion-exchange method, and since magnesium sulfate acts as a dehydrating agent, the water generated in the esterification reaction is removed, and thus the occurrence of hydrolysis (i.e., reverse reaction) is suppressed and a conversion rate to the desired ester compound is increased. In addition, since the reactants are inexpensive and the product is less hazardous and easy to handle, a more efficient reaction is possible.

公开(公告)号：US20230225387A1

公开(公告)日：2023-07-20

申请号：US18192023

申请日：2023-03-29

申请人： Nutrition21, LLC

发明人： James R. Komorowski

IPC分类号： A23L33/175 ,  C07C279/14 ,  A23L2/52 ,  A23L3/46 ,  C07C277/08

CPC分类号： A23L33/175 ,  A23L2/52 ,  A23L3/46 ,  C07C277/08 ,  C07C279/14 ,  A23V2002/00

摘要： Methods of manufacturing inositol-stabilized arginine-silicate (“ASI”) complexes with reduced or eliminated clumping and with increased solubility.

公开(公告)号：US11279784B2

公开(公告)日：2022-03-22

申请号：US16437061

申请日：2019-06-11

申请人： Molecular Insight Pharmaceuticals, Inc.

发明人： Jason Moss ,  Machinani Rao

IPC分类号： C08F230/04 ,  A61K51/04 ,  C07C279/06 ,  A61P35/00 ,  C07C277/08 ,  A61K31/155

摘要： The present disclosure provides purified forms of iobenguane and preparations of a precursor to iobenguane, such as a polymer, the polymer comprising a monomer of formula (I) or a pharmaceutically acceptable salt thereof, the preparation comprising leachable tin at a level of 0 ppm to 850 ppm.

公开(公告)号：US20210284774A1

公开(公告)日：2021-09-16

申请号：US17255643

申请日：2019-07-02

申请人： Cytec Industries Inc.

发明人： Jeremy MOSKOWITZ ,  William JACOBS ,  Amy TUCKER ,  Billy HARMON

IPC分类号： C08F220/18 ,  C07C277/08 ,  D01F9/22 ,  D01F6/38 ,  D01D1/02 ,  D01D1/04 ,  D01D10/06

摘要： A polymer comprising repeating units derived from a first monomer, typically acrylonitrile, and repeating units derived from a second monomer different from the first monomer, wherein the second monomer is a compound comprising an ethylenically unsaturated organic anion and an organic cation containing a C═N imine group; a process for producing carbon fibers using the said polymer; and carbon fibers made therefrom, are described herein.

公开(公告)号：US11103000B2

公开(公告)日：2021-08-31

申请号：US17150892

申请日：2021-01-15

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski

IPC分类号： A23L33/175 ,  C07C279/14 ,  A23L2/52 ,  A23L3/46 ,  C07C277/08

摘要： Methods of manufacturing inositol-stabilized arginine-silicate (“ASI”) complexes with reduced or eliminated clumping and with increased solubility.

公开(公告)号：US20210177029A1

公开(公告)日：2021-06-17

申请号：US17150892

申请日：2021-01-15

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski

IPC分类号： A23L33/175 ,  C07C279/14 ,  C07C277/08 ,  A23L2/52 ,  A23L3/46

摘要： Methods of manufacturing inositol-stabilized arginine-silicate (“ASI”) complexes with reduced or eliminated clumping and with increased solubility.

公开(公告)号：US11013760B2

公开(公告)日：2021-05-25

申请号：US16411703

申请日：2019-05-14

申请人： Sealife Pharma GmbH

发明人： Alexander Pretsch ,  Michael Nagl ,  Christoph Wiesner ,  Ralph Hollaus ,  Miroslav Genov

IPC分类号： C07C279/00 ,  A61K31/785 ,  A61K45/06 ,  A61K31/155 ,  C07C277/08 ,  A01N47/44 ,  C07D213/42 ,  C08G73/00 ,  C08G73/06

摘要： Polyguanidines and methods of use thereof are described. In particular, polyguanidines of formula (I), formula (II), and formula (III) are described. The polyguanidines can be used to treat infection, such as bacterial, viral or fungal infection, and as an ex vivo microbial agent.

公开(公告)号：US10335431B2

公开(公告)日：2019-07-02

申请号：US15500772

申请日：2015-07-30

申请人： Sealife Pharma GmbH

发明人： Alexander Pretsch ,  Michael Nagl ,  Christoph Wiesner ,  Ralph Hollaus ,  Miroslav Genov

IPC分类号： C07C277/08 ,  A61K31/785 ,  A61K45/06 ,  A61K31/155 ,  A01N47/44 ,  C07C279/00 ,  C07D213/42 ,  C08G73/00 ,  C08G73/06

摘要： A method for preparing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl or allyl derivatives BA according to the following reaction scheme is provided: wherein X, R1, Gua, Y and Z are as defined in the specification. In the disclosed method, at least one benzyl or allyl derivative BA is subjected to a polycondensation reaction with excessive guanidine, aminoguanidine or diaminoguanidine G upon elimination of HX.

公开(公告)号：US10202337B2

公开(公告)日：2019-02-12

申请号：US15129927

申请日：2015-03-23

申请人： KANEKA CORPORATION

发明人： Koji Machida ,  Kohei Mori ,  Narumi Kishimoto ,  Toshihiro Takeda

IPC分类号： C07C277/08

摘要： A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride and a base in a water/organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.

公开(公告)号：US10167275B2

公开(公告)日：2019-01-01

申请号：US15822060

申请日：2017-11-24

申请人： SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD.

发明人： Xuenong Xu

IPC分类号： C07D403/04 ,  C07C277/08 ,  C07C279/18

摘要： Disclosed are an intermediate, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-formamidine]phenyl-2-propenamide (II), applicable in preparing AZD9291 (I) and a preparation method for the intermediate. Preparation steps of the preparation method comprise: 2-fluoro-4-methoxyaniline, serving as a starting material, undergoes amidation, substitution, nitrification, reduction and guanidination reactions to prepare N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-formamidine]phenyl-2-propenamide (II). Also disclosed is a method for preparing AZD9291 (I) by means of a cyclization reaction between the compound of a formula II and (2E)-3-dimethylamino-1-(1-methyl-1H-indol-3-yl)-2-propen-1-one (III). The preparation method has readily available raw materials and a simple process and is economical, environmentally friendly, and suitable for industrialized production.