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    NUCLEIC ACIDS THAT ENCODE SODIUM CHANNEL
    53.
    发明申请
    NUCLEIC ACIDS THAT ENCODE SODIUM CHANNEL 有权
    编入钠通道的核酸

    公开(公告)号：US20110028689A1

    公开(公告)日：2011-02-03

    申请号：US12755317

    申请日：2010-04-06

    Applicant: Sho-Ya WANG

    Inventor： Sho-Ya WANG

    IPC: C07K14/47 ,  C07H21/00

    CPC classification number: G01N33/6872 ,  C07K14/705 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5061 ,  G01N2500/10

    Abstract: A method or screen for assessing the potential of a compound to treat a pathological condition, such as arrhythmia, which is manifested by an increased late sodium current in a heart is disclosed. The method employs a mutant sodium channel protein having an amino acid sequence in which one or more amino acids among the ten amino acids occurring at the carboxy end of the S6 segments of D1, D2, D3 or D4 domains of mammalian Nav1 differs from the amino acid in wild-type Nav1 by substitution with tryptophan, phenylalanine, tyrosine or cysteine. Cells transfected with a nucleic acid that encodes a mutant mammalian Nav1 protein, as well as isolated nucleic acid comprising a nucleotide sequence that codes for a mutant mammalian Nav1 protein are disclosed.

    Abstract translation: 公开了用于评估化合物治疗病理状况（例如心律不齐）的潜力的方法或筛选，其由心脏中的晚期钠电流增加而表现。 该方法采用具有氨基酸序列的突变型钠通道蛋白，其中在哺乳动物Nav1的D1，D2，D3或D4结构域的S6段的羧基末端存在的10个氨基酸中的一个或多个氨基酸与氨基酸不同 通过用色氨酸，苯丙氨酸，酪氨酸或半胱氨酸取代，在野生型Nav1中产生酸。 公开了用编码突变型哺乳动物Nav1蛋白的核酸转染的细胞，以及包含编码突变型哺乳动物Nav1蛋白的核苷酸序列的分离的核酸。

    METHOD FOR PROTEIN STRUCTURE DETERMINATION, GENE IDENTIFICATION, MUTATIONAL ANALYSIS, AND PROTEIN DESIGN
    55.
    发明申请
    METHOD FOR PROTEIN STRUCTURE DETERMINATION, GENE IDENTIFICATION, MUTATIONAL ANALYSIS, AND PROTEIN DESIGN 审中-公开
    蛋白质结构测定方法，基因鉴定，突变分析和蛋白质设计

    公开(公告)号：US20100304983A1

    公开(公告)日：2010-12-02

    申请号：US12301963

    申请日：2008-04-18

    Applicant: Charles Michael Fortmann ,  Yeona Kang ,  David H. Coleman

    Inventor： Charles Michael Fortmann ,  Yeona Kang ,  David H. Coleman

    IPC: C40B30/02

    CPC classification number: G16B15/00

    Abstract: An efficient computational method and system for predicting the folding regions and associated secondary and tertiary structures of a protein is disclosed. Methods and systems for sorting amino acid sequences based on predicted structures, as well as methods and systems for determining the presence or absence of genes in nucleic acid sequences or structural mutations in amino acid sequences are also disclosed. A method and system for the design of a protein is also disclosed.

    Abstract translation: 公开了一种用于预测蛋白质的折叠区域和相关的二级结构和三级结构的有效计算方法和系统。 还公开了基于预测结构排序氨基酸序列的方法和系统，以及用于确定核酸序列中基因的存在或不存在或氨基酸序列中的结构突变的方法和系统。 还公开了一种用于设计蛋白质的方法和系统。

    Bridging centrality: a concept and formula to identify bridging nodes in scale-free networks
    57.
    发明授权
    Bridging centrality: a concept and formula to identify bridging nodes in scale-free networks 失效
    桥接中心性：确定无大规模网络中的桥接节点的概念和公式

    公开(公告)号：US07808921B2

    公开(公告)日：2010-10-05

    申请号：US11804700

    申请日：2007-05-18

    Applicant: Aidong Zhang ,  Murali Ramanathan ,  Woo-Chang Hwang ,  Young-Rae Cho

    Inventor： Aidong Zhang ,  Murali Ramanathan ,  Woo-Chang Hwang ,  Young-Rae Cho

    IPC: H04L12/26 ,  H04L12/28

    CPC classification number: H04L45/123 ,  H04L41/12 ,  H04L41/145 ,  H04L41/16

    Abstract: A method for identifying a bridge node in a network using a processor and memory unit in a specially programmed special purpose-purpose computer including the steps of, for each node in a plurality of nodes in the network: determining a global metric proportional to total traffic flow in the network and through the node; determining a local metric proportional to traffic flow between the node and each second node in the network connected to the node and traffic flow between each second node and each third node in the network connected to a second node; determining a second local metric proportional to the respective traffic flows between each node and each second node; and calculating a respective combination of the global metric and the first and second local metrics; and selecting, a bridge node from among the plurality of nodes based on the respective combinations.

    Abstract translation: 一种用于使用专门编程的特殊用途计算机中的处理器和存储器单元来识别网络中的网桥节点的方法，包括以下步骤：对于网络中的多个节点中的每个节点：确定与总流量成比例的全局度量 流经网络并通过节点; 确定与连接到节点的网络中的节点与每个第二节点之间的业务流量成比例的本地度量，以及连接到第二节点的网络中每个第二节点与每个第三节点之间的业务流; 确定与每个节点和每个第二节点之间的相应业务流成比例的第二本地度量; 以及计算所述全局度量和所述第一和第二局部度量的相应组合; 以及基于各个组合从多个节点中选择一个桥接节点。

    pH-change sensor and method
    58.
    发明授权
    pH-change sensor and method 有权
    pH变化传感器和方法

    公开(公告)号：US07794584B2

    公开(公告)日：2010-09-14

    申请号：US11548995

    申请日：2006-10-12

    Applicant: Vamsy P. Chodavarapu ,  Alexander N. Cartwright ,  Albert H. Titus ,  Rachel M. Bukowski ,  Frank V. Bright

    Inventor： Vamsy P. Chodavarapu ,  Alexander N. Cartwright ,  Albert H. Titus ,  Rachel M. Bukowski ,  Frank V. Bright

    IPC: G01N27/327 ,  G01N27/333 ,  G01N27/414

    CPC classification number: G01N27/4148 ,  G01N27/4145

    Abstract: pH-change sensors and related methods are disclosed. One such sensor may have a first ion-sensitive transistor-operational-transconductance-amplifier (the “first IOTA”) and a second ion-sensitive transistor-operational-transconductance-amplifier (the “second IOTA”). Each IOTA may have an ion-sensitive transistor, a load transistor, and an output. In each IOTA, the drain region of the ion-sensitive transistor may be connected to the drain region of the load transistor. A differential sensor may be connected to the IOTAs, and an output from the differential sensor may indicate a voltage difference between the IOTA outputs. The output from the differential sensor may be used to provide an indication of a change in pH.

    Abstract translation: 公开了pH变化传感器和相关方法。 一个这样的传感器可以具有第一离子敏感晶体管 - 工作跨导放大器（“第一IOTA”）和第二离子敏感晶体管 - 工作跨导放大器（“第二IOTA”）。 每个IOTA可以具有离子敏感晶体管，负载晶体管和输出。 在每个IOTA中，离子敏感晶体管的漏极区域可以连接到负载晶体管的漏极区域。 差分传感器可以连接到IOTA，差分传感器的输出可以指示IOTA输出之间的电压差。 差分传感器的输出可用于提供pH变化的指示。

    ELECTRONIC COLON CLEANSING METHOD FOR VIRTUAL COLONOSCOPY
    59.
    发明申请
    ELECTRONIC COLON CLEANSING METHOD FOR VIRTUAL COLONOSCOPY 有权
    用于虚拟结肠镜的电子束清洗方法

    公开(公告)号：US20100208956A1

    公开(公告)日：2010-08-19

    申请号：US12095645

    申请日：2006-11-29

    Applicant: Jerome Z. Liang ,  Zigang Wang

    Inventor： Jerome Z. Liang ,  Zigang Wang

    IPC: G06K9/62 ,  G06K9/00

    CPC classification number: G06K9/34 ,  G06K2209/053

    Abstract: A method for electronically cleansing a virtual object formed from acquired image data converted to a plurality of volume elements is provided. The present method allows individual volume elements, or voxels, to represent more than one material type. The method includes defining a partial volume image model for volume elements representing a plurality of material types based, at least in part, on the measured intensity value of the volume element. The material mixture for each of the volume elements representing a plurality of material types can be estimated using the observed intensity values and the defined partial volume image model. The volume elements representing a plurality of material types can then be classified in accordance with the estimated material mixture. For electronic colon cleansing, the method includes removing at least one classification of volume elements when displaying the virtual object.

    Abstract translation: 提供了一种用于电子清洗从被转换为多个体积元素的获取的图像数据形成的虚拟对象的方法。 本方法允许单个体积元素或体素表示多于一种的材料类型。 该方法包括至少部分地基于体积元素的测量强度值来定义表示多种材料类型的体积元素的部分体积图像模型。 可以使用观察到的强度值和限定的部分体积图像模型来估计表示多种材料类型的每个体积元素的材料混合物。 然后可以根据所估计的材料混合物来分类代表多种材料类型的体积元素。 对于电子结肠清洗，该方法包括在显示虚拟对象时移除体积元素的至少一个分类。

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