公开(公告)号：US20240082578A1

公开(公告)日：2024-03-14

申请号：US18372099

申请日：2023-09-24

Applicant: Ivan OSORIO

Inventor： Ivan OSORIO

IPC: A61N1/36

CPC classification number: A61N1/36064 ,  A61N1/36139 ,  A61N1/36142 ,  A61N1/0529

Abstract: A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.

公开(公告)号：US20230270345A1

公开(公告)日：2023-08-31

申请号：US18138218

申请日：2023-04-24

Applicant: Ivan Osorio ,  Alexey Lyubushin ,  Didier Sornette

Inventor： Ivan Osorio ,  Alexey Lyubushin ,  Didier Sornette

IPC: A61B5/0205 ,  A61B5/16 ,  A61B5/00 ,  A61B5/374

CPC classification number: A61B5/02055 ,  A61B5/0205 ,  A61B5/165 ,  A61B5/374 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/726 ,  A61B5/746 ,  A61B5/024

Abstract: A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

公开(公告)号：US20230162862A1

公开(公告)日：2023-05-25

申请号：US18100870

申请日：2023-01-24

Applicant: IVAN OSORIO

Inventor： IVAN OSORIO

IPC: G16H50/20 ,  A61B5/00 ,  A61B5/16 ,  G16H50/30 ,  G16H50/70 ,  A61B5/389 ,  G16Z99/00 ,  A61B5/0205 ,  A61B5/11 ,  G16H40/67

CPC classification number: G16H50/20 ,  A61B5/4842 ,  A61B5/7275 ,  A61B5/165 ,  A61B5/4035 ,  G16H50/30 ,  G16H50/70 ,  A61B5/389 ,  G16Z99/00 ,  A61B5/4094 ,  A61B5/02055 ,  A61B5/11 ,  A61B5/42 ,  A61B5/7246 ,  A61B5/7282 ,  A61B5/746 ,  G16H40/67 ,  A61B5/01

Abstract: Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

公开(公告)号：US11219374B2

公开(公告)日：2022-01-11

申请号：US15729168

申请日：2017-10-10

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio ,  Alexey Lyubushin ,  Didier Sornette

IPC: G01N33/48 ,  G01N33/50 ,  A61B5/0205 ,  A61B5/16 ,  A61B5/00 ,  A61B5/374 ,  A61B5/024 ,  A61B5/08 ,  A61B5/11 ,  A61B5/24 ,  A61B5/369 ,  A61B5/083 ,  A61B5/145

Abstract: A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

公开(公告)号：US11026623B2

公开(公告)日：2021-06-08

申请号：US15726683

申请日：2017-10-06

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio

IPC: A61B5/00 ,  A61B5/11 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/024 ,  A61B5/08 ,  A61B5/1455

Abstract: We report a method of determining an occurrence of an epileptic convulsive seizure in a patient, comprising: receiving body data from a patient during a first time period, determining a work level relating to said first time period at least based partially upon said body data; determining whether said work level exceeds an extreme work level threshold; performing a responsive action, in response to a determination that said work level exceeds said extreme work level threshold. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

公开(公告)号：US11026622B2

公开(公告)日：2021-06-08

申请号：US15009568

申请日：2016-01-28

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio ,  Mark G. Frei

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/024 ,  A61N1/36 ,  A61B5/35 ,  A61B5/316 ,  A61B5/349 ,  A61B5/352 ,  A61B5/364 ,  A61B5/0245

Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.

公开(公告)号：US20200206508A1

公开(公告)日：2020-07-02

申请号：US16798370

申请日：2020-02-23

Applicant: Ivan OSORIO

Inventor： Ivan OSORIO

IPC: A61N1/36

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US20190328307A1

公开(公告)日：2019-10-31

申请号：US16452699

申请日：2019-06-26

Applicant: IVAN OSORIO

Inventor： IVAN OSORIO

IPC: A61B5/00 ,  G16H20/10 ,  A61B5/11 ,  G16H50/20 ,  G16H50/30 ,  A61B5/0205 ,  G16H20/40 ,  A61B5/145 ,  A61B5/042 ,  A61M16/10 ,  A61N1/36 ,  A61B5/0476 ,  A61B5/04

Abstract: A method for identifying changes in an epilepsy patient's disease state, comprising: receiving at least one body data stream; determining at least one body index from the at least one body data stream; detecting a plurality of seizure events from the at least one body index; determining at least one seizure metric value for each seizure event; performing a first classification analysis of the plurality of seizure events from the at least one seizure metric value; detecting at least one additional seizure event from the at least one determined index; determining at least one seizure metric value for each additional seizure event, performing a second classification analysis of the plurality of seizure events and the at least one additional seizure event based upon the at least one seizure metric value; comparing the results of the first classification analysis and the second classification analysis; and performing a further action.

公开(公告)号：US20190298923A1

公开(公告)日：2019-10-03

申请号：US16447045

申请日：2019-06-20

Applicant: Ivan OSORIO

Inventor： Ivan OSORIO

IPC: A61M5/172 ,  A61B17/132 ,  A61F7/00 ,  A61N1/36 ,  A61F7/12

Abstract: We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

公开(公告)号：US20190000378A1

公开(公告)日：2019-01-03

申请号：US16112657

申请日：2018-08-25

Applicant: Ivan Osorio

Inventor： Ivan Osorio

IPC: A61B5/00 ,  G06F19/00 ,  G16H50/70 ,  G16H50/30 ,  A61B5/0205

Abstract: Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.