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51.发明申请公开(公告)号：US20210123027A1
公开(公告)日：2021-04-29
申请号：US17257182
申请日：2019-10-10
发明人： Yasuhiro KAZUKI , Narumi UNO , Mitsuo OSHIMURA
摘要： The present application provides: a method for producing human induced pluripotent stem (iPS) cells comprising an exogenous chromosome having a DNA of interest using the MMCT method; and a method for expressing the exogenous gene in the human iPS cells prepared by the method for producing human iPS cells, or in undifferentiated or differentiated cells derived from the human iPS cells induced to differentiate from the human iPS cells.
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公开(公告)号：US20210056704A1
公开(公告)日：2021-02-25
申请号：US16966488
申请日：2019-01-30
摘要： A data processing method that is suitable for obtaining quantitative information from data obtained by OCT imaging. The image processing method includes acquiring original image data corresponding to a three-dimensional image of a cultured embryo obtained by optical coherence tomography imaging of the embryo and executing a region segmentation the three-dimensional image into a plurality of regions on the basis of the original image data. In the region segmentation, a local thickness calculation is performed on the three-dimensional image to determine an index value indicating a size of an object included in the three-dimensional image, the three-dimensional image is segmented into a region indicated by the index value greater than a predetermined first threshold and a region indicated by the index value less than the first threshold, and each of the regions resulting from the segmentation is further segmented by the watershed algorithm.
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公开(公告)号：US20210042968A1
公开(公告)日：2021-02-11
申请号：US16966486
申请日：2019-01-30
摘要： A technique capable of providing a user with information obtained by OCT imaging in a useful way, particularly for assisting in assessment of an embryo effectively. The image processing method includes acquiring original signal data indicating an intensity distribution of signal light from each position in three-dimensional space including a cultured embryo obtained by optical coherence tomography imaging, generating spherical coordinate data based on the original signal data, the spherical coordinate data indicating a relationship between each position in the three-dimensional space represented using spherical coordinates having an origin set inside the embryo and the intensity of the signal light from the position, and outputting the intensity distribution of the signal light as a two-dimensional map based on the spherical coordinate data using two deflection angles of the spherical coordinates as coordinate axes.
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公开(公告)号：US10888594B2
公开(公告)日：2021-01-12
申请号：US15664125
申请日：2017-07-31
IPC分类号： C12N15/863 , A61K48/00 , A61K35/76 , C12N7/01 , C07K14/54 , A61K35/768 , C12N7/00 , A61K38/20 , C12N15/86
摘要： The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
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公开(公告)号：US10849946B2
公开(公告)日：2020-12-01
申请号：US15664125
申请日：2017-07-31
IPC分类号： C12N15/863 , A61K48/00 , A61K35/76 , C12N7/01 , C07K14/54 , A61K35/768 , C12N7/00 , A61K38/20 , C12N15/86
摘要： The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
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公开(公告)号：US10413546B2
公开(公告)日：2019-09-17
申请号：US15548550
申请日：2016-02-23
申请人： NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY , NIPPON MEDICAL SCHOOL FOUNDATION , NIPPON CHEMIPHAR CO., LTD.
发明人： Takeshi Nishino , Shinsuke Kato , Masako Kato , Hidenori Suzuki , Ken Okamoto
IPC分类号： A61K31/519 , A61K31/437 , A61K31/4365 , A61K31/4355 , A61P25/28 , A61K31/403 , A61K31/4184 , A61K31/423 , A61K31/428
摘要： A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase inhibitory action as an active ingredient.
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公开(公告)号：USD838839S1
公开(公告)日：2019-01-22
申请号：US29614368
申请日：2017-08-18
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公开(公告)号：US20170131175A1
公开(公告)日：2017-05-11
申请号：US15414965
申请日：2017-01-25
申请人： NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY , NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY
摘要： This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.
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59.发明授权Cartilage production promoter and prophylactic or therapeutic agent for diseases associated with cartilage damage 有权软骨产生促进剂和与软骨损伤有关的疾病的预防或治疗剂公开(公告)号：US09539280B2
公开(公告)日：2017-01-10
申请号：US14327928
申请日：2014-07-10
发明人： Saburo Minami , Yoshiharu Okamoto , Yasunari Miki
IPC分类号： A61K31/737 , A61K31/726 , C08B37/00
CPC分类号： A61K31/737 , A61K31/726 , C08B37/0036
摘要： Disclosed is a therapy which is for preventing or treating cartilage damage and diseases associated with cartilage damage, such as arthritides and osteoarthritis, and utilizes a more effective and more safe medicinal agent. Specifically disclosed are a cartilage production promoter, a glucosaminoglycan and/or proteoglycan production promoter, and a prophylactic or therapeutic agent for diseases associated with cartilage damage, each of which comprises fucoidan as an active ingredient.
摘要翻译： 公开了用于预防或治疗软骨损伤和与软骨损伤相关的疾病如关节炎和骨关节炎的治疗，并且利用更有效和更安全的药剂。 具体公开的是软骨生产促进剂，葡糖胺聚糖和/或蛋白聚糖生产促进剂，以及与软骨损伤相关的疾病的预防或治疗剂，其中每一种都包含岩藻依聚糖作为活性成分。
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公开(公告)号：US20150005506A1
公开(公告)日：2015-01-01
申请号：US14372961
申请日：2013-01-25
IPC分类号： A61K31/426
CPC分类号： A61K31/426
摘要： The purpose of the present invention is to provide a novel therapeutic agent or a novel prophylactic agent for diseases associated with abnormal glucose metabolism. The present invention is a therapeutic agent or a prophylactic agent for diseases associated with abnormal glucose metabolism, which comprises a 2-phenylthiazole compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明的目的是提供用于与葡萄糖代谢异常相关的疾病的新型治疗剂或新型预防剂。 本发明涉及与异常葡萄糖代谢相关的疾病的治疗剂或预防剂，其包含由式（I）表示的2-苯基噻唑化合物或其药学上可接受的盐作为活性成分。
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