公开(公告)号：US07393859B2

公开(公告)日：2008-07-01

申请号：US10848893

申请日：2004-05-19

Applicant: Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

Inventor： Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

IPC: A61K31/437 ,  C07D471/02

CPC classification number: C07D471/04 ,  A61K31/4745

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US07220758B2

公开(公告)日：2007-05-22

申请号：US11459489

申请日：2006-07-24

Applicant: Joseph F. Dellaria ,  Kyle J. Lindstrom ,  Luke T. Dressel ,  Philip D. Heppner ,  John R. Jacobsen ,  Joan T. Moseman ,  William H. Moser ,  Matthew R. Radmer ,  Doris Stoermer

Inventor： Joseph F. Dellaria ,  Kyle J. Lindstrom ,  Luke T. Dressel ,  Philip D. Heppner ,  John R. Jacobsen ,  Joan T. Moseman ,  William H. Moser ,  Matthew R. Radmer ,  Doris Stoermer

IPC: A61K31/437 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Abstract translation: 在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。 还公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US07038053B2

公开(公告)日：2006-05-02

申请号：US11177948

申请日：2005-07-08

Applicant: Kyle J. Lindstrom ,  Luke T. Dressel

Inventor： Kyle J. Lindstrom ,  Luke T. Dressel

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine and converting a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine to a 1H-imidazo[4,5-c]pyridin-4-amine.

Abstract translation: 公开了制备1H-咪唑并[4,5-c]吡啶-4-胺的方法和中间体。 该方法包括提供7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶，并将7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶转化为1H- 咪唑并[4,5-c]吡啶-4-胺。

公开(公告)号：US06943255B2

公开(公告)日：2005-09-13

申请号：US10856975

申请日：2004-05-28

Applicant: Kyle J. Lindstrom ,  Luke T. Dressel

Inventor： Kyle J. Lindstrom ,  Luke T. Dressel

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 7H-imidazo[4,5-c]tetrazolo[1,5-α]pyridine and converting a 7H-imidazo[4,5-c]tetrazolo[1,5-α]pyridine to a 1H-imidazo[4,5-c]pyridin-4-amine.

Abstract translation: 公开了制备1H-咪唑并[4,5-c]吡啶-4-胺的方法和中间体。 该方法包括提供7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶并将7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶转化成1H- 咪唑并[4,5-c]吡啶-4-胺。

公开(公告)号：US06878719B2

公开(公告)日：2005-04-12

申请号：US10754056

申请日：2004-01-07

Applicant: Kyle J. Lindstrom ,  Philip D. Heppner

Inventor： Kyle J. Lindstrom ,  Philip D. Heppner

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06784188B2

公开(公告)日：2004-08-31

申请号：US10370800

申请日：2003-02-20

Applicant: Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

Inventor： Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

IPC: A61K314745

CPC classification number: C07D471/04 ,  A61K31/4745 ,  Y02A50/409

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06756382B2

公开(公告)日：2004-06-29

申请号：US10027218

申请日：2001-12-21

Applicant: Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

Inventor： Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

IPC: A61K3144

CPC classification number: C07D471/04 ,  A61K31/4745

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06716988B2

公开(公告)日：2004-04-06

申请号：US10357777

申请日：2003-02-04

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: C07D213643

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06696465B2

公开(公告)日：2004-02-24

申请号：US10322262

申请日：2002-12-17

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Byron A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Byron A. Merrill

IPC: A61K31437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06545016B1

公开(公告)日：2003-04-08

申请号：US10165229

申请日：2002-06-07

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: A61K31437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.