公开(公告)号：US20090111982A1

公开(公告)日：2009-04-30

申请号：US12341517

申请日：2008-12-22

Applicant: Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

Inventor： Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

IPC: C07D487/04 ,  C07D401/12 ,  C07D403/02

CPC classification number: C07K5/0804

Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

公开(公告)号：US07220734B2

公开(公告)日：2007-05-22

申请号：US10536730

申请日：2003-12-16

Applicant: George A. Doherty ,  Jeffrey J. Hale ,  Sander G. Mills

Inventor： George A. Doherty ,  Jeffrey J. Hale ,  Sander G. Mills

IPC: A61K31/397 ,  A61K31/4245 ,  A61K31/41 ,  A61K31/4025 ,  A61K31/381 ,  C07D271/06 ,  C07D257/04 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D205/04 ,  C07D333/16 ,  C07D409/10 ,  C07D409/12 ,  C07D413/10 ,  C07D413/14

Abstract: The present invention encompasses compounds of Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

Abstract translation: 本发明包括式（I）的化合物：及其药学上可接受的盐和水合物。 该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。 包括药物组合物和使用方法。