公开(公告)号：US20170355725A9

公开(公告)日：2017-12-14

申请号：US15297384

申请日：2016-10-19

Applicant: Genentech, Inc.

Inventor： Thomas Pillow

IPC: C07H15/207 ,  A61K39/395

CPC classification number: C07H15/207 ,  A61K39/39558 ,  A61K47/545 ,  A61K47/6807 ,  A61K47/6809

Abstract: The invention relates generally to a calicheamicin molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody directly conjugated by a disulfide to one or more calicheamicin molecules.

公开(公告)号：US20170348422A1

公开(公告)日：2017-12-07

申请号：US15613477

申请日：2017-06-05

Applicant: Genentech, Inc.

Inventor： Thomas Pillow ,  Andrew G. Polson ,  Bing Zheng

IPC: A61K47/54 ,  A61K31/357 ,  G01N33/567 ,  A61K39/00

CPC classification number: A61K47/541 ,  A61K31/357 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6855 ,  A61K2039/572 ,  A61K2039/627 ,  C07D407/12 ,  C07K19/00 ,  G01N33/567

Abstract: The invention relates generally to a silvestrol molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody conjugated by a linker to one or more silvestrol drug moieties and methods of treatment.

公开(公告)号：US20160279260A1

公开(公告)日：2016-09-29

申请号：US15181825

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： John Flygare ,  Janet Gunzner-Toste ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  Guiling Zhao ,  Leanna Staben

IPC: A61K47/48 ,  C07K16/30 ,  C07K16/28

CPC classification number: A61K47/6803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  C07K16/28 ,  C07K16/2851 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

Abstract translation: 本发明涉及肽模拟接头及其抗体药物偶联物，含有它们的药物组合物及其在治疗中用于预防或治疗癌症的用途。