公开(公告)号：US07687627B2

公开(公告)日：2010-03-30

申请号：US10935708

申请日：2004-09-07

申请人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugh ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

发明人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugh ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

IPC分类号： C07D491/113 ,  A61K31/438

CPC分类号： C07D491/10 ,  C07D413/10 ,  C07D413/14 ,  C07D495/10 ,  C07D497/10 ,  C07D513/10

摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

公开(公告)号：US06750224B1

公开(公告)日：2004-06-15

申请号：US09640947

申请日：2000-08-17

申请人： Mahesh Vithalbhai Patel ,  Shivkumar Agarwal ,  Sreenivas Kandepu ,  Nitin Shetty ,  Dilip Upadhyay ,  Nishith Chaturvedi ,  Abraham Thomas ,  Noel John De Souza ,  Habil Fakhruddin Khorakiwala

发明人： Mahesh Vithalbhai Patel ,  Shivkumar Agarwal ,  Sreenivas Kandepu ,  Nitin Shetty ,  Dilip Upadhyay ,  Nishith Chaturvedi ,  Abraham Thomas ,  Noel John De Souza ,  Habil Fakhruddin Khorakiwala

IPC分类号： A61K3144

CPC分类号： A61K31/4745 ,  C07B2200/07 ,  C07C279/14 ,  C07D455/04

摘要： The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions can be used to systemically and topically treat bacterial Gram-positive, Gram-negative and anaerobic infections, specially resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and emerging nosocomial pathogen infections, while avoiding toxic effects associated with the administration of the racemic mixture of RS-(±)-benzoquinolizine carboxylic acid. The compounds and compositions of this invention can also be used to treat diseases and disorders caused by Gram-positive, Gram-negative and anaerobic bacteria, and diseases and disorders caused by resistant Gram-positive organisms, Gram-negative organisms, mycobacteria and nosocomial pathogens.

摘要翻译： 本发明涉及基本上不含其R - （+） - 异构体的光学纯的S - （ - ） - 苯并喹嗪羧酸，其衍生物，盐，假多晶型物，多晶型物和水合物，用于制备光学纯S - （ - ） - 苯并喹嗪羧酸，它们的衍生物，盐，假多晶型物，基本上不含其R - （+） - 异构体的多晶型物和水合物，以及包含S（ - ） - 苯醌喹唑啉羧酸的衍生物， 盐，假多晶型物，多晶型物及其水合物。 这些化合物和组合物可用于全身和局部治疗细菌革兰氏阳性，革兰氏阴性和厌氧感染，特异性抗性革兰氏阳性生物感染，革兰氏阴性生物感染，分枝杆菌感染和新出现的医院病原体感染，同时避免毒性作用 与对 - （±） - 苯并喹嗪羧酸的外消旋混合物的给药相关。 本发明的化合物和组合物还可用于治疗由革兰氏阳性，革兰氏阴性和厌氧细菌引起的疾病和病症，以及由抗性革兰氏阳性生物，革兰氏阴性菌，分枝杆菌和医院病原体引起的疾病和病症 。