知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

89 records (took 0.021 seconds)

    MODIFIED MULTIMERIC BICYCLIC PEPTIDE LIGANDS
    42.
    发明申请
    MODIFIED MULTIMERIC BICYCLIC PEPTIDE LIGANDS 有权

    公开(公告)号：US20220275053A1

    公开(公告)日：2022-09-01

    申请号：US17630754

    申请日：2020-08-13

    Applicant: BicycleTx Limited

    Inventor： Punit UPADHYAYA ,  Gemma Elizabeth MUDD ,  Kevin MCDONNELL

    IPC: C07K14/705 ,  A61K47/64 ,  C07K7/06 ,  A61P35/00

    Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold, characterised in that said multimeric binding complex additionally comprises a modifier group conjugated thereto. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders and activators of CD137. The invention also includes drug conjugates comprising said multimeric binding complexes, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said multimeric binding complexes and drug conjugates and to the use of said multimeric binding complexes and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137 and to the use in an analytical method (i.e. as a tracer or a tag).

    BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EPHA2
    43.
    发明申请
    BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EPHA2 有权

    公开(公告)号：US20220257784A1

    公开(公告)日：2022-08-18

    申请号：US17630314

    申请日：2020-07-30

    Applicant: BicycleTx Limited

    Inventor： Punit UPADHYAYA ,  Johanna LAHDENRANTA ,  Gemma MUDD ,  Kevin MCDONNELL

    IPC: A61K47/64 ,  C07K14/00 ,  C07K11/02

    Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of the Eph receptor tyrosine kinase A2 (EphA2). The invention also relates to pharmaceutical compositions comprising said peptide ligands and to the use of said peptide ligands in preventing, suppressing or treating a disease or disorder characterised by overexpression of EphA2 in diseased tissue (such as a tumour).

    BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CD137
    44.
    发明申请
    BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CD137 有权

    公开(公告)号：US20220213145A1

    公开(公告)日：2022-07-07

    申请号：US17648560

    申请日：2022-01-21

    Applicant: BicycleTx Limited

    Inventor： Liuhong CHEN ,  Rachid LANI ,  Kevin MCDONNELL ,  Gemma Elizabeth MUDD ,  Peter PARK

    IPC: C07K7/64 ,  A61K47/64

    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

    PEPTIDE LIGANDS FOR BINDING TO PSMA
    46.
    发明申请
    PEPTIDE LIGANDS FOR BINDING TO PSMA 有权

    公开(公告)号：US20220194983A1

    公开(公告)日：2022-06-23

    申请号：US17254339

    申请日：2019-06-19

    Applicant: BicycleTx Limited

    Inventor： Daniel TEUFEL ,  Gemma MUDD ,  Silvia PAVAN ,  Kevin MCDONNELL ,  Punit UPADHYAYA

    IPC: C07K7/08 ,  A61K47/64 ,  A61P35/00

    Abstract: A peptide ligand specific for prostate specific membrane antigen (PSMA) comprising a polypeptide comprising three residues selected from cysteine, L-2,3-diaminopropionic acid (Dap), N-beta-alkyl-L-2,3-diaminopropionic acid (N-AlkDap) and N-beta-haloalkyl-L-2,3-diaminopropionic acid (N-HAlkDap), with the proviso that at least one of said three residues is selected from Dap, N-AlkDap or N-HAlkDap, the said three residues being separated by at least two loop sequences, and a molecular scaffold, the peptide being linked to the scaffold by covalent alkylamino linkages with the Dap or N-AlkDap or N-HAlkDap residues of the polypeptide and by thioether linkages with the cysteine residues of the polypeptide when the said three residues include cysteine, such that two polypeptide loops are formed on the molecular scaffold.

    BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR INTEGRIN ALPHA-V-BETA-3
    47.
    发明申请
    BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR INTEGRIN ALPHA-V-BETA-3 有权

    公开(公告)号：US20220064221A1

    公开(公告)日：2022-03-03

    申请号：US17422935

    申请日：2020-01-15

    Applicant: BicycleTx Limited

    Inventor： Rachid LANI ,  Catherine STACE ,  Daniel TEUFEL ,  Edward WALKER

    IPC: C07K7/60 ,  C07K7/64 ,  A61K47/64 ,  C07K19/00

    Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of integrin αvβ3. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by integrin αvβ3.

    PEPTIDE LIGANDS FOR BINDING TO MT1-MMP
    49.
    发明申请
    PEPTIDE LIGANDS FOR BINDING TO MT1-MMP 审中-公开

    公开(公告)号：US20190389907A1

    公开(公告)日：2019-12-26

    申请号：US16472234

    申请日：2017-12-20

    Applicant: BicycleTx Limited

    Inventor： Daniel Teufel ,  Gemma Mudd ,  Silvia Pavan

    IPC: C07K7/08 ,  G01N33/573 ,  A61K47/64

    Abstract: A peptide ligand specific for MT1-MMP comprising a polypeptide comprising two diaminopropionic acid (Dap) or N-alkyldiaminopropionic acid (N-AlkDap) residues, and a third residue selected from cysteine, Dap or N-AlkDap, separated by at least two loop sequences, and a molecular scaffold, the peptide being linked to the scaffold by covalent alkylamino linkages with the Dap or N-AlkDap residues of the polypeptide and by covalent thioether linkages with the cysteine when the third residue is cysteine, such that two polypeptide loops are formed on the molecular scaffold, wherein the peptide ligand comprises an amino acid sequence of formula (II): -A1-X1-U/O2-X3-X4-G5-A2-E6-D7-F8-Y9-X10-X11-A3- (SEQ ID NO: 1) (II) or a pharmaceutically acceptable salt thereof; wherein: A1, A2, and A3 are independently cysteine, L-2,3-diaminopropionic acid (Dap), N-beta-alkyl-L-2,3-diaminopropionic acid (N-AlkDap), or N-beta-haloalkyl-L-2,3-diaminopropionic acid (N-HAlkDap), provided that at least one of A1, A2, and A3 is Dap, N-AlkDap or N-HAlkDap; X represents any amino acid residue; U represents a polar, uncharged amino acid residue selected from N, C, Q, M, S and T; and O represents a non-polar aliphatic amino acid residue selected from G, A, I, L, P and V.

Patent Agency Ranking