公开(公告)号：US10781161B2

公开(公告)日：2020-09-22

申请号：US16419949

申请日：2019-05-22

申请人： Yale University

发明人： Gerald I. Shulman ,  David A. Spiegel

IPC分类号： C07C205/37 ,  A61K31/085 ,  C07J41/00

摘要： The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.

公开(公告)号：US20200253996A1

公开(公告)日：2020-08-13

申请号：US16651719

申请日：2018-10-01

申请人： UNIVERSITE PARIS-SUD ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT GUSTAVE-ROUSSY

发明人： Samir MESSAOUDI ,  Mouad ALAMI ,  Jean-Daniel BRION ,  Amélie CHABRIER ,  Adam TELERMAN ,  Robert AMSON

IPC分类号： A61K31/706 ,  A61K31/7068 ,  A61P35/00 ,  A61K31/015 ,  A61K31/085 ,  A61K31/03 ,  A61K31/09 ,  A61K31/235 ,  A61K31/11 ,  A61K31/165 ,  A61K31/352 ,  A61K31/404 ,  A61K31/472 ,  A61K31/382 ,  A61K31/704 ,  A61K31/197 ,  A61K31/24 ,  A61K31/135

摘要： The present invention relates to the compounds of formula (I) below: wherein: X represents an oxygen atom, a sulfur atom, a nitrogen atom or a CH radical, The bond X—Y and Y are absent if X represents an oxygen or sulfur atom, the bond X—Y and Y are present if X represents a nitrogen atom or a CH radical, When present, Y represents a group R if X represents a nitrogen atom, a hydrogen atom or a group —NR1R2 if X represents a CH radical, (Het)Ar is an aromatic ring selected from the group consisting of aryl and heteroaryl groups, R3, R4, R5, R6 represent, independently of one another, a hydrogen atom, a halogen atom, a —NR12R13, a —SR14 group, a —OR14 group or a —CF3 group, When Y is —NR1R2, the groups —NR1R2 and (Het)Ar are in the cis-conformation, or a pharmaceutically acceptable salt thereof, for use in the treatment of proliferative diseases, infectious diseases, allergies, inflammation and/or asthma.

公开(公告)号：US20200214988A1

公开(公告)日：2020-07-09

申请号：US16721302

申请日：2019-12-19

申请人： Oxford University Innovation Limited

发明人： John Hagan Pryce Bayley ,  Andrew Heron ,  Gabriel Villar

IPC分类号： A61K9/50 ,  B01J13/02 ,  A61K9/113 ,  C09B67/02 ,  A61K31/085 ,  A61K49/00

摘要： The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.

公开(公告)号：US20200046651A1

公开(公告)日：2020-02-13

申请号：US16536449

申请日：2019-08-09

申请人： Metagenics, Inc.

发明人： Nikhat Contractor ,  Jennifer Joan Ryan

IPC分类号： A61K31/12 ,  A61K31/085 ,  A61K36/906 ,  A61K31/366 ,  A61K36/53 ,  A61K31/519 ,  A61K31/714 ,  A61K31/198 ,  A61P1/04

摘要： A composition for treatment of inflammation in a mammal is provided. The mammal has a neutrophil to lymphocyte ratio (NLR). The composition includes a curcumagalactomannoside and a hops extract. The curcumagalactomannoside and the hops extract cooperate to decrease the NLR of the mammal 12 weeks after ingestion of the composition. A method of treatment of inflammation in a mammal is also provided. The method includes obtaining a parameter of the mammal. The method further includes dosing the composition based on the parameter. The method further includes administering the composition to the mammal.

公开(公告)号：US20200016116A1

公开(公告)日：2020-01-16

申请号：US16488936

申请日：2018-02-23

申请人： Wendy Anne Epstein

发明人： Wendy Anne Epstein

IPC分类号： A61K31/353 ,  A61K9/00 ,  A61K31/085 ,  A61K31/566

摘要： The invention provides safe and efficacious treatments for the improvement of male and female sexual function, cutaneous inflammation such as psoriasis, eczema, dermatitis and Female Sexual Disorders, such as Genitopelvic Pain/Penetration Disorders; vulvovaginal atrophy, vestibulodynia, dyspareunia, Sexual Interest/Arousal Disorder, low female libido and Female Orgasmic Disorder.

公开(公告)号：US20190350917A1

公开(公告)日：2019-11-21

申请号：US16412275

申请日：2019-05-14

申请人： Alkahest, Inc.

发明人： Meghan Kerrisk Campbell ,  Eva Czirr ,  Balazs Szoke

IPC分类号： A61K31/47 ,  A61K31/197 ,  A61K31/085 ,  A61K31/353 ,  C07K16/40 ,  A61P25/28

摘要： Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include inhibitors or antagonists of leukotriene A4 hydrolase (“LTA4H”) with efficacy in treating and/or preventing aging-related conditions such as neurocognitive disorders.

公开(公告)号：US10457629B2

公开(公告)日：2019-10-29

申请号：US14914408

申请日：2014-08-28

申请人： Yale University

发明人： Gerald I. Shulman ,  David A. Spiegel

IPC分类号： C07C205/37 ,  A61K31/085 ,  C07J41/00

摘要： The present invention includes DNP derivatives of formula (I) that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.

公开(公告)号：US20190298790A1

公开(公告)日：2019-10-03

申请号：US16294740

申请日：2019-03-06

申请人： Allergan, Inc.

发明人： Anuradha V. Gore ,  Jaya Giyanani ,  Sukhon Likitlersuang

IPC分类号： A61K36/55 ,  A61K31/05 ,  A61K9/00 ,  A61K31/085

摘要： Stabilized ophthalmic compositions containing omega-3 oils are provided, which are useful as artificial tears and as ophthalmic compositions to diagnose, treat, or prevent keratoconjunctivitis or dry eye syndrome in a human or other mammal.

公开(公告)号：US20190262389A1

公开(公告)日：2019-08-29

申请号：US16409587

申请日：2019-05-10

申请人： Marie H. JHIN

发明人： Marie H. JHIN ,  Hanafi TANOJO

IPC分类号： A61K31/78 ,  A61K8/43 ,  A61K31/09 ,  A61Q17/00 ,  A61K9/00 ,  A61K8/81 ,  B65B1/04 ,  A61K8/34 ,  A61K31/155 ,  A61K31/085

摘要： A dermal protector liquid including a barrier and antimicrobial materials is disclosed. The protector liquid can be sprayed onto the skin. The protector liquid can have a dispersant and moisturizer. When the base and solvents of the liquid evaporate, a polymer barrier and antimicrobial material can continue to reside on the skin.

公开(公告)号：US10376529B2

公开(公告)日：2019-08-13

申请号：US14897948

申请日：2014-06-12

申请人： NATAC BIOTECH, S.L

发明人： José Carlos Quintela Fernández ,  Esther De La Fuente García ,  Marco Pugliese ,  Pilar Mancera Aroca ,  Javier Bustos Santafé ,  Juan Francisco Espinosa Parrilla ,  Noemí Virgili Treserres ,  Blanca Wappenhans Battestini

IPC分类号： A61K31/7034 ,  A61K31/05 ,  A61K31/19 ,  A61K31/191 ,  A61K31/7048 ,  A61K9/00 ,  A61K31/047 ,  A61K31/085 ,  A23L33/10

摘要： The present invention is related to a product comprising a pentacyclic triterpene of formula (I) and a hydroxytyrosol or derivatives thereof of formula (II), pharmaceutical compositions thereof and their uses as antioxidants, anti-inflammatories and neuron protectors.