公开(公告)号：US20230147832A1

公开(公告)日：2023-05-11

申请号：US17794913

申请日：2021-01-22

申请人： CITY OF HOPE

发明人： Jianhua Yu ,  Michael A. Caligiuri

IPC分类号： A61K35/17 ,  C07K14/54 ,  C12N15/62 ,  C12N7/00 ,  C07K14/715 ,  A61P35/00

CPC分类号： A61K35/17 ,  C07K14/5443 ,  C12N15/62 ,  C12N7/00 ,  C07K14/7155 ,  A61P35/00

摘要： Provided herein, inter alia, are compositions and methods including recombinant oncolytic viruses expressing human IL-15 and human IL-15Rα-sushi domain for the treatment of cancer and immune disorders. The recombinant oncolytic viruses may be used in combination with immune cells expressing chimeric antigen receptors (CAR) targeting EGFR and EGFR mutants.

公开(公告)号：US20230141575A1

公开(公告)日：2023-05-11

申请号：US17906467

申请日：2021-03-18

申请人： CITY OF HOPE

发明人： John C. WILLIAMS ,  Miso PARK

IPC分类号： C07K14/54 ,  A61P35/00

CPC分类号： C07K14/5443 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2319/50 ,  C07K2319/30 ,  A61K38/00

摘要： Provided herein are, inter alia, multi-specific ligand binding complexes capable of binding tumor-associated antigens and effector cell activating ligands. The complexes provided herein may include a first ligand binding domain (e.g., a Fab) capable of binding a tumor antigen. The complexes further include a second ligand binding domain (e.g., IL-15) non-covalently and/or covalently attached to a second ligand binding domain enhancer. The complexes provided herein are, inter alia, useful for the treatment of cancer.

公开(公告)号：US20230135500A1

公开(公告)日：2023-05-04

申请号：US17976670

申请日：2022-10-28

申请人： CITY OF HOPE

发明人： Yuman Fong ,  Colin Andrew Cook ,  Thomas J Gernon ,  Stanley Ralph Hamilton ,  Marylin Roque ,  Kevin Alexander Proudfoot ,  Sophie Yu ,  Natalie Krieger ,  Vivian Ho Lam ,  Kaitlyn Paulsen ,  Kaushal Gokli ,  Leila Wiberg ,  Tristan Aniken Huang ,  Vadim Peter Mathys

IPC分类号： A61B10/02 ,  A61B10/00

摘要： Methods of manufacture, devices, and systems are described for a nasal swab. The swab includes an elongated body having a distal end. The swab includes a collection layer proximate to the distal end of the elongated body. The collection layer has a first geometric layout and configured to collect samples in the nasal passageway. The swab includes a collection tip at the distal end of the elongated body, the collection tip having a second geometric layout and configured to collect samples in the nasal passageway. The first geometric layout is different from the second geometric layout.

公开(公告)号：US20230097513A1

公开(公告)日：2023-03-30

申请号：US17759254

申请日：2021-02-02

申请人： CITY OF HOPE

发明人： Don J. DIAMOND ,  Felix WUSSOW

IPC分类号： C12N15/86 ,  A61K39/00 ,  A61P35/00 ,  A61K39/245 ,  A61K39/215 ,  A61P31/14 ,  A61P31/22

摘要： Disclosed are methods of producing poxvirus-based vectors or recombinant poxvirus-based vectors from naturally derived, chemically synthesized DNA fragments, or a combination of naturally derived and chemically synthesized DNA fragments. One or more DNA sequences encoding one or more antigens, subunits or fragments thereof or other heterologous gene sequences are inserted in one or more poxvirus insertion sites in one or more DNA fragments. The methods include transfecting a host cell with one or more circular or linear DNA fragments such that a poxvirus or recombinant poxvirus is reconstituted in the host cell, the reconstituted poxvirus or recombinant poxvirus comprising the genome of a desired poxvirus. Also disclosed are poxviruses or recombinant poxviruses produced by the technology and uses thereof.

公开(公告)号：US20230076643A1

公开(公告)日：2023-03-09

申请号：US17789930

申请日：2020-12-30

申请人： CITY OF HOPE

发明人： Jose Enrique Montero Casimiro ,  Bart Otto Roep ,  Christine E. Brown

IPC分类号： C07K16/28 ,  C12N15/86 ,  A61K35/17 ,  C07K16/24 ,  A61P35/00

摘要： Provided herein are, inter alia, CAR-T cell compositions targeting CD6, CD19, and/or an IL-13R, and methods useful for treating autoimmune diseases and cancer.

公开(公告)号：US20230070158A1

公开(公告)日：2023-03-09

申请号：US16758516

申请日：2018-10-23

申请人： City of Hope

发明人： John Zaia ,  Kevin Morris ,  Xiuli Wang

IPC分类号： A61K39/245 ,  C12N5/0783 ,  A61P31/18 ,  C07K14/725 ,  C07K16/10

摘要： Methods of treatment for HIV employing T cells expressing both a chimeric antigen receptors targeted to HIV and a CMV-specific T cell receptor.

公开(公告)号：US11583509B2

公开(公告)日：2023-02-21

申请号：US15804587

申请日：2017-11-06

申请人： CITY OF HOPE

发明人： Samuel Rahbar ,  James L. Figarola ,  Christopher Lincoln ,  David Horne ,  Rachael Mooney ,  Monika Polewski ,  George Somlo ,  Lixin Yang ,  Sanjay Awasthi ,  Sharad Singhal ,  Jyotasana Singhal

IPC分类号： A61K31/4745 ,  A61K31/17 ,  A61K45/06 ,  A61K31/513 ,  C07D229/00 ,  A61K31/495

摘要： One aspect of the disclosure relates to the use of derivatives of dichlorophenyl urea for treating cancers.

公开(公告)号：US20220411797A1

公开(公告)日：2022-12-29

申请号：US17849294

申请日：2022-06-24

申请人： City of Hope ,  The Regents of the University of California

发明人： Carlotta A. GLACKIN ,  John ROSSI ,  Jeffrey I. ZINK ,  Fuyuhiko TAMANOI ,  Cai M. ROBERTS ,  James FINLAY

IPC分类号： C12N15/113 ,  A61K47/69

摘要： The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.

公开(公告)号：US11535847B2

公开(公告)日：2022-12-27

申请号：US16702318

申请日：2019-12-03

申请人： City of Hope

发明人： Piotr Swiderski

IPC分类号： C12N15/11 ,  C12N15/113

摘要： Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide.

公开(公告)号：US11524937B2

公开(公告)日：2022-12-13

申请号：US16594894

申请日：2019-10-07

申请人： CITY OF HOPE ,  THE NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

发明人： Sangkil Nam ,  Richard Jove ,  Leandros Skaltsounis

IPC分类号： C07D209/40 ,  C07D401/14

摘要： Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). Indirubin derivatives (IRDs) potently reduce the viabilities of various cancer cells and affect kinase activities. IRDs disclosed herein provide new therapeutics for cancer and conditions regulated by the kinase activities.