公开(公告)号：US06980858B2

公开(公告)日：2005-12-27

申请号：US10040977

申请日：2001-12-31

Applicant: Kristine B. Fuimaono ,  Shahram Moaddeb

Inventor： Kristine B. Fuimaono ,  Shahram Moaddeb

IPC: A61N1/39 ,  A61N1/05 ,  A61N1/365

CPC classification number: A61N1/0563

Abstract: A method and system for atrial defibrillation in a patient are provided. The method comprises introducing into the patient a catheter comprising an elongated catheter body having proximal and distal ends and at least one lumen therethrough, and a basket-shaped electrode assembly at the distal end of the catheter body. The electrode assembly has proximal and distal ends and comprises a plurality of spines connected at their proximal and distal ends, each spine comprising an elongated spine electrode along its length. The electrode assembly has an expanded arrangement wherein the spines bow radially outwardly and a collapsed arrangement wherein the spines are arranged generally along the axis of the catheter body. The method further comprises introducing the electrode assembly into the heart of the patient and applying defibrillation energy to the tissue through one or more of the elongated electrodes. The system comprises a catheter as described above in combination with an external defibrillator electrically connected to the catheter.

Abstract translation: 提供了一种患者心房除颤的方法和系统。 所述方法包括向患者引入导管，该导管包括具有近端和远端以及穿过其中的至少一个腔的细长导管本体，以及位于导管主体远侧的筐形电极组件。 电极组件具有近端和远端，并且包括在其近端和远端连接的多个脊，每个脊沿其长度包括细长的脊柱电极。 电极组件具有扩展的布置，其中脊柱径向向外弯曲并且具有塌缩的布置，其中脊通常沿着导管主体的轴线布置。 该方法还包括将电极组件引入患者的心脏中，并通过一个或多个细长电极向组织施加除颤能量。 该系统包括如上所述的导管和与导管电连接的外部除颤器。

公开(公告)号：US06402719B1

公开(公告)日：2002-06-11

申请号：US08924342

申请日：1997-09-05

Applicant: Dean M. Ponzi ,  Shahram Moaddeb

Inventor： Dean M. Ponzi ,  Shahram Moaddeb

IPC: A61M3700

CPC classification number: A61B18/24 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2018/00392 ,  A61M1/1072

Abstract: A steerable, direct myocardial revascularization catheter comprises a catheter body, a control handle, a tip section, and a means for deflecting the tip section by manipulation of the control handle. The catheter body has an outer wall, proximal and distal ends and at least one lumen extending therethrough. The control handle is situated at the proximal end of the catheter body. The tip section comprises a flexible tubing having proximal and distal ends and at least one lumen therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The catheter also comprises an optic fiber having proximal and distal ends. The optic fiber extends through a lumen in a catheter body and tip section. The distal end of the optic fiber is substantially flush with the distal end of the tip section. The catheter further comprises an infusion tube having proximal and distal ends. The infusion tube extends through a lumen in the catheter body and tip section. The distal end of the infusion tube is fixedly situated within the tip section, and the proximal end of the infusion tube extends outside of the catheter body for receiving fluids. A method for inducing revascularization in the heart tissue comprises providing a catheter as described above, inserting the catheter into a heart chamber, transmitting sufficient laser energy through the optic fiber to create a channel in the heart wall, and administering at least one drug to the channel through the infusion tube.

Abstract translation: 可引导的直接心肌血运重建导管包括导管主体，控制手柄，尖端部分和用于通过操纵控制手柄偏转尖端部分的装置。 导管主体具有外壁，近端和远端以及延伸穿过其中的至少一个内腔。 控制手柄位于导管主体的近端。 尖端部分包括柔性管，其具有近端和远端以及穿过其中的至少一个腔。 尖端部分的近端固定地附接到导管主体的远端。导管还包括具有近端和远端的光纤。 光纤延伸穿过导管主体和尖端部分的内腔。 光纤的远端基本与尖端部分的远端齐平。 导管还包括具有近端和远端的输液管。 输液管延伸穿过导管主体和尖端部分的内腔。 输液管的远端固定地位于尖端部分内，并且输液管的近端延伸到导管主体的外部以便接收流体。1.一种用于诱导心脏组织血运重建的方法，包括提供如上所述的导管， 将导管插入心室中，通过光纤透射足够的激光能量以在心脏壁中产生通道，以及通过输注管给予通道至少一种药物。

公开(公告)号：US6024739A

公开(公告)日：2000-02-15

申请号：US924612

申请日：1997-09-05

Applicant: Dean M. Ponzi ,  Shahram Moaddeb

Inventor： Dean M. Ponzi ,  Shahram Moaddeb

IPC: A61B17/00 ,  A61B18/24 ,  A61B17/36

CPC classification number: A61B18/24 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2018/00392 ,  A61B2034/2051

Abstract: A method for direct myocardial revascularization by providing a catheter with a catheter body having proximal and distal ends and at least one lumen extending therethrough, a control handle at the proximal end of the catheter body, and a tip section having proximal and distal ends. The tip section is fixedly attached to the distal end of the catheter body. The catheter also comprises an electromagnetic sensor in the distal portion tip section for producing electrical signals indicative of the location of the electromagnetic sensor. The catheter further comprises at least one electrode carried by the tip section for mapping electrical activity of the heart tissue and at least one electrode lead wire electrically connected to the electrode. An optic fiber is provided within the catheter with its distal end being substantially flush with the distal end of the tip section. Manipulation of the control handle results in deflection of the tip section. The method further comprises inserting the catheter through a blood vessel into a heart chamber, monitoring the location of the distal end of the catheter tip section within the heart on a visual display, contacting the heart wall with at least one electrode to measure the electrical activity of the heart at the points of contact to locate ischemic areas of the heart tissue, deflecting the tip section so that the distal ends of the tip section and optic fiber are generally normal to an ischemic area of heart tissue, and transmitting sufficient laser energy through the optic fiber to create a channel in the heart tissue.

Abstract translation: 一种用于直接心肌血运重建的方法，其通过提供具有导管主体的导管，所述导管主体具有近端和远端以及延伸穿过其中的至少一个内腔，所述导管主体的近端处的控制手柄以及具有近端和远端的尖端部分。 尖端部分固定地附接到导管主体的远端。 导管还包括在远端部分尖端部分中的电磁传感器，用于产生指示电磁传感器位置的电信号。 该导管还包括至少一个由尖端部分承载的电极，用于映射心脏组织的电活动和电连接到电极的至少一个电极引线。 在导管内提供光纤，其远端基本上与尖端部分的远端齐平。 控制手柄的操纵导致尖端部分的偏转。 所述方法还包括将导管穿过血管插入心室，监测心脏内的导管尖端部分的远端在视觉显示器上的位置，使心壁与至少一个电极接触以测量电活动 的心脏接触位置以定位心脏组织的缺血区域，偏转尖端部分，使得尖端部分和光纤的远端通常垂直于心脏组织的缺血区域，并且透射足够的激光能量通过 光纤在心脏组织中形成通道。

公开(公告)号：US5324325A

公开(公告)日：1994-06-28

申请号：US38564

申请日：1993-03-26

Applicant: Shahram Moaddeb

Inventor： Shahram Moaddeb

IPC: A61N1/05

CPC classification number: A61N1/0575

Abstract: A lead for delivering electrical stimulation pulses to pace the cardiac muscle and for sensing electrical signals occurring in the cardiac muscle is disclosed which as a rigid helix disposed at the extreme distal end thereof which rigid helix may be operated by the implanting physical to extend the tip of the rigid helix from a stored position within the distal end of the lead to a deployed position projecting from the distal end of the lead. The rigid helix pierces and engages the heart tissue to anchor the lead in place within the heart. The tip of the rigid helix has an axial bore therein which is filled with a therapeutic medication such as a steroid or steroid-based drug for inhibiting inflammation and promoting tissue growth. After the tip of the helical screw is disposed in the heart tissue, the therapeutic medication will be slowly eluted into the surrounding tissue, thereby minimizing the trauma of implantation and assisting in the anchoring of the lead.

Abstract translation: 公开了用于传递电刺激脉冲以调节心肌和感测心肌中发生的电信号的导联，其作为设置在其最远端处的刚性螺旋，其刚性螺旋可以通过植入物理来操作以延伸尖端 的刚性螺旋从引线的远端内的存储位置移动到从引线的远端突出的展开位置。 刚性螺旋刺穿并接合心脏组织以将引线固定在心脏内的适当位置。 刚性螺旋的尖端在其中具有轴向孔，其中填充有治疗药物，例如用于抑制炎症和促进组织生长的类固醇或基于类固醇的药物。 在将螺旋形螺钉的尖端设置在心脏组织中之后，治疗药物将缓慢地洗脱到周围组织中，从而最小化植入的创伤并辅助引导的锚固。

公开(公告)号：US08715159B2

公开(公告)日：2014-05-06

申请号：US13158117

申请日：2011-06-10

Applicant: Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

Inventor： Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

IPC: A61F2/00

CPC classification number: A61F5/0053 ,  A61F5/003 ,  A61F5/0059 ,  A61F5/0066 ,  A61F2005/002

Abstract: A system includes an adjustable implant configured for implantation internally within a subject, the adjustable implant comprising a first permanent magnet configured for rotation about a first axis, the first permanent magnet operatively coupled to a drive transmission configured to alter a dimension of the adjustable implant. The system further includes an external adjustment device configured for placement on or adjacent to the skin of the subject, the external adjustment device comprising a second permanent magnet configured for rotation about a second axis and a third permanent magnet configured for rotation about a third axis different from the second axis; and wherein cooperative rotation of the second permanent magnet about the second axis and rotation of the third permanent magnet about the third axis result in rotation of the first permanent magnet about the first axis.

Abstract translation: 系统包括被配置用于在对象内部进行植入的可调节植入物，所述可调节植入物包括被配置为围绕第一轴线旋转的第一永久磁体，所述第一永久磁体可操作地耦合到构造成改变所述可调节植入物的尺寸的驱动变速器。 该系统还包括外部调节装置，其被配置用于放置在与受试者皮肤相邻或相邻的外部，所述外部调节装置包括构造成围绕第二轴线旋转的第二永磁体和被配置为围绕第三轴线旋转的第三永磁体 从第二轴; 并且其中所述第二永磁体围绕所述第二轴线的协同旋转和所述第三永磁体围绕所述第三轴线的旋转导致所述第一永磁体围绕所述第一轴线的旋转。

公开(公告)号：US20110257740A1

公开(公告)日：2011-10-20

申请号：US13079429

申请日：2011-04-04

Applicant: Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel M. Shaolian

Inventor： Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel M. Shaolian

IPC: A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a first body member including a first shape memory material configured to transform the annuloplasty ring from a first configuration having a first size of a dimension to a second configuration having a second size of the dimension. The second size is less than said first size in septal lateral distance. The devices also include a second body member including a second shape memory material configured to transform the annuloplasty ring from the second configuration to a third configuration having a third size of the dimension, wherein the second size is less than the third size in septal lateral distance.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，所述装置包括第一主体构件，所述第一主体构件包括第一形状记忆材料，所述第一形状记忆材料构造成将瓣膜成形术环从具有尺寸的第一尺寸的第一构型转换成具有尺寸的第二尺寸的第二构型。 第二尺寸小于所述第一尺寸在间隔侧向距离。 所述装置还包括第二主体构件，所述第二主体构件包括第二形状记忆材料，所述第二形状记忆材料构造成将瓣膜成形术环从第二构型转换成具有尺寸的第三尺寸的第三构型，其中第二尺寸小于第三尺寸的间隔横向距离 。

公开(公告)号：US20110230962A1

公开(公告)日：2011-09-22

申请号：US12941918

申请日：2010-11-08

Applicant: Shahram Moaddeb ,  Samuel Shaolian

Inventor： Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/24

CPC classification number: A61F2/2457

Abstract: Embodiments of a dynamically adjustable artificial chordae tendinae implant are described. In some embodiments the implant includes a body portion, including an adjustable portion. In some embodiments, the implant includes a plurality of adjustable portions. In some embodiments the adjustable element can include a shape memory material. The adjustable portion can be configured to transform from a first conformation to a second conformation in response to an activation energy. In some embodiments, the activation energy can be one of electromagnetic energy, acoustic energy, light energy, thermal energy, electrical energy, mechanical energy, or a combination of energies. The implant couples a heart valve leaflet to a papillary muscle. Activation of the shape memory material regulates tension between the muscle and valve leaflet improving coaptation of heart valve leaflets, and reducing or eliminating regurgitation.

Abstract translation: 描述了动态调节的人造腱索植入物的实施例。 在一些实施例中，植入物包括主体部分，其包括可调部分。 在一些实施例中，植入物包括多个可调部分。 在一些实施例中，可调元件可以包括形状记忆材料。 可调节部分可以被配置为响应于活化能量从第一构象转变成第二构象。 在一些实施例中，激活能可以是电磁能，声能，光能，热能，电能，机械能或能量的组合中的一种。 植入物将心脏瓣膜小叶结合到乳头肌。 形状记忆材料的激活调节肌肉和瓣膜瓣之间的张力，改善心脏瓣膜小叶的接合，并减少或消除反流。

公开(公告)号：US07862502B2

公开(公告)日：2011-01-04

申请号：US11760482

申请日：2007-06-08

Applicant: Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

Inventor： Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

IPC: A61B17/00 ,  A61B17/12

CPC classification number: A61F5/0053 ,  A61F5/003 ,  A61F5/0059 ,  A61F5/0066 ,  A61F2005/002

Abstract: A gastrointestinal implant system includes an adjustable restriction device having a contact surface configured for at least partially engaging a surface of a gastrointestinal tract of a mammal. The implant system further includes an implantable interface including a first driving element, the first driving element being moveable and operatively coupled to the adjustable restriction device by an actuator configured to change the dimension or configuration of the contact surface in response to movement of the first driving element. The system also includes an external adjustment device having a second driving element configured to non-invasively engage the first driving element of the implantable interface from a location external to the mammal. In the system, actuation of the second driving element of the external adjustment device produces movement in the first driving element of the implantable interface and results in a change in the dimension or configuration of the contact surface.

Abstract translation: 消化道植入系统包括可调节限制装置，其具有构造成用于至少部分地接合哺乳动物的胃肠道表面的接触表面。 所述植入系统还包括可植入界面，其包括第一驱动元件，所述第一驱动元件可移动并通过构造成响应于所述第一驱动件的移动来改变所述接触表面的尺寸或构造而被可操作地联接到所述可调节限制装置 元件。 该系统还包括具有第二驱动元件的外部调整装置，该第二驱动元件构造成从哺乳动物外部的位置非侵入地接合可植入界面的第一驱动元件。 在该系统中，外部调节装置的第二驱动元件的致动在可植入界面的第一驱动元件中产生运动并且导致接触表面的尺寸或构型的变化。

公开(公告)号：US07722668B2

公开(公告)日：2010-05-25

申请号：US12032476

申请日：2008-02-15

Applicant: Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel M. Shaolian

Inventor： Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel M. Shaolian

IPC: A61F2/06

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material, and an energy absorption enhancement material configured to absorb energy in response to an activation energy. The energy absorption enhancement material is in thermal communication with said shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration, and is configured to be implanted in the first configuration into a heart. The body member is configured to transform from the first configuration to the second configuration in response to the activation energy. The second configuration is configured to reduce a dimension of a cardiac valve annulus in the heart.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施方案中，所述装置包括包括形状记忆材料的主体构件和被配置为响应于活化能吸收能量的能量吸收增强材料。 能量吸收增强材料与所述形状记忆材料热连通。 主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸，并且构造成以第一构造植入心脏。 身体构件被配置为响应于激活能量从第一配置变换到第二配置。 第二配置被配置为减小心脏中的心脏瓣膜环的尺寸。

公开(公告)号：US07536228B2

公开(公告)日：2009-05-19

申请号：US11728010

申请日：2007-03-22

Applicant: Samuel Shaolian ,  Shahram Moaddeb ,  Maurice Buchbinder ,  David Zarbatany ,  Jason Tran

Inventor： Samuel Shaolian ,  Shahram Moaddeb ,  Maurice Buchbinder ,  David Zarbatany ,  Jason Tran

IPC: A61N1/18

CPC classification number: A61F2/2445 ,  A61F2/2466 ,  A61F2250/0001

Abstract: An activation device for applying energy to an implanted annuloplasty ring is described. In some embodiments, the activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween. In some embodiments, the activation device further includes an inner elongate member having a inner elongate member distal end and a inner elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one energy-transfer element coupled to the adjustable spline.

Abstract translation: 描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。 在一些实施例中，激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔。 在一些实施例中，激活装置还包括具有内部细长构件远端和内部细长构件近端的内部细长构件和其间的内腔，其中内部细长构件可滑动地插入穿过外部细长构件的内腔。 在一些实施例中，激活装置还包括具有花键近端和花键远端的至少一个可调节花键，花键远端连接到内部管状构件远端，花键近端连接到外部管状构件远端，其中， 当内部细长构件驻留在外部细长构件的内腔中时，可调节花键构造成随着内部管状构件远端朝向外部管状构件远端被拉近而弯曲。 在一些实施例中，激活装置还包括耦合到可调节花键的至少一个能量传递元件。