公开(公告)号：US20050014704A1

公开(公告)日：2005-01-20

申请号：US10735179

申请日：2003-12-12

Applicant: Wendelin Frick ,  Heiner Glombik ,  Werner Kramer ,  Hurbert Heuer ,  Harm Brummerhop ,  Oliver Plettenburg

Inventor： Wendelin Frick ,  Heiner Glombik ,  Werner Kramer ,  Hurbert Heuer ,  Harm Brummerhop ,  Oliver Plettenburg

IPC: A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  A61P3/10 ,  C07H15/203 ,  C07H17/02

CPC classification number: C07H15/203

Abstract: Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and process for their preparation. The compounds are suitable for example as antidiabetics.

Abstract translation: 新型芳香族氟代糖苷衍生物，含有这些化合物的药物及其用途。 本发明涉及其中基团具有所述含义的式I的取代芳族氟代糖苷衍生物及其生理学耐受盐及其制备方法。 该化合物适合于例如抗糖尿病药。

公开(公告)号：US5430116A

公开(公告)日：1995-07-04

申请号：US992411

申请日：1992-12-17

Applicant: Werner Kramer ,  Stefan Mullner ,  Matthias Gutweiler ,  Matthias Kroggel

Inventor： Werner Kramer ,  Stefan Mullner ,  Matthias Gutweiler ,  Matthias Kroggel

IPC: A23L1/30 ,  A61K31/375 ,  A61K31/78 ,  A61K31/785 ,  A61K47/32 ,  A61P1/16 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J41/00 ,  C07J43/00 ,  C08F12/00 ,  C08F12/02 ,  C08F12/26 ,  C08F16/14 ,  C08F16/16 ,  C08F16/26 ,  C08F16/36 ,  C08F16/38 ,  C08F18/02 ,  C08F20/26 ,  C08F20/52 ,  C08F20/54 ,  C08F20/58 ,  C08F22/40 ,  C08F26/02 ,  C08F26/10 ,  C08F220/28 ,  C08F226/10 ,  C11D1/02 ,  C08F232/08 ,  C08F222/02 ,  C08F222/04 ,  C08F222/10

CPC classification number: C07J9/005 ,  C07J41/0061 ,  C08F12/26 ,  C08F20/54

Abstract: Polymeric and oligomeric bile acids are described which can be prepared by polymerization of monomeric bile acids of the formula IG--X--A (I)in which G, X and A have the given meanings or by copolymerization with a monomer of the formula IV ##STR1## in which R.sup.9 and R.sup.10 have the given meanings, or by copolymerization with N-vinylpyrrolidone or its derivatives,and/or by copolymerization with ethylenically unsaturated dicarboxylic anhydrides and ethylenically unsaturated dicarboxylic acids each having 2 to 6 carbon atoms; their esters or half esters, alkyl esters having 1-6 carbon atoms, cycloalkyl esters having 5 to 8 carbon atoms, benzyl esters or phenyl esters being understood as esters. They can be used as pharmaceuticals, foodstuff additives, formulation auxiliaries and detergents.

Abstract translation: 描述了可以通过聚合式I GXA（I）的单体胆汁酸制备的聚合和低聚胆汁酸，其中G，X和A具有给定的含义或通过与式IV的单体共聚 ，或通过与N-乙烯基吡咯烷酮或其衍生物共聚，和/或通过与烯键式不饱和二羧酸酐和各自具有2至6个碳原子的烯键式不饱和二羧酸进行共聚合; 它们的酯或半酯，具有1-6个碳原子的烷基酯，具有5-8个碳原子的环烷基酯，苄基酯或苯基酯被理解为酯。 它们可以用作药物，食品添加剂，配方助剂和洗涤剂。

公开(公告)号：US5428182A

公开(公告)日：1995-06-27

申请号：US074753

申请日：1993-06-10

Applicant: Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Gunther Wess

Inventor： Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Gunther Wess

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00 ,  C07J51/00

CPC classification number: C07J41/0055 ,  C07J41/0005 ,  C07J9/005

Abstract: Bile acid derivatives of the formula IZ(X--GS)nin which GS, X, Z and n have the meanings indicated in the specification, and a process for the preparation of these compounds are described. The compounds are pharmacologically active and can, therefore, be used as pharmaceuticals, in particular as a hypolipidemic.

Abstract translation: 描述了其中GS，X，Z和n具有本说明书中指出的含义的式I Z（X-GS）n的胆汁酸衍生物及其制备方法。 这些化合物是药理活性的，因此可以用作药物，特别是降血脂药。

公开(公告)号：US5250524A

公开(公告)日：1993-10-05

申请号：US802413

申请日：1991-12-04

Applicant: Werner Kramer ,  Gunther Wess ,  Stefan Mullner ,  Horst Neubauer

Inventor： Werner Kramer ,  Gunther Wess ,  Stefan Mullner ,  Horst Neubauer

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  A61K31/56 ,  C07J53/00

CPC classification number: C07J43/003 ,  C07J31/006 ,  C07J41/0016 ,  C07J41/0055 ,  C07J41/0061 ,  C07J41/0094 ,  C07J9/005

Abstract: The invention relates to bile acid derivatives of the formula IG1--X--G2 (I)in whichG1 and G2 are bile acid radicals or modified bile acid radicals in the form of the free acids, the esters or amides, the salt forms and also the forms derivatized on the alcohol groups andX is a bridge group or a single covalent bond, it being possible for G1 and G2 to be optionally bonded via X.The compounds according to the invention have a high affinity for the specific bile acid transport system of the small intestine and inhibit bile acid absorption in a concentration-dependent and competitive manner.

Abstract translation: 本发明涉及式I G1-X-G2（I）的胆汁酸衍生物，其中G1和G2是游离酸，酯或酰胺，盐形式的胆汁酸基或改性胆汁酸基， 还有在醇基上衍生的形式，X是桥基或单个共价键，可以通过X任选地键合G1和G2。根据本发明的化合物对于特定的胆汁酸转运具有高亲和力 小肠系统，以浓度依赖性和竞争性抑制胆汁酸吸收。

公开(公告)号：US07772429B2

公开(公告)日：2010-08-10

申请号：US11690993

申请日：2007-03-26

Applicant: Gerhard Jaehne ,  Wendelin Frick ,  Andreas Lindenschmidt ,  Stefanie Flohr ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer ,  Eric Galia ,  Heiner Glombik

Inventor： Gerhard Jaehne ,  Wendelin Frick ,  Andreas Lindenschmidt ,  Stefanie Flohr ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer ,  Eric Galia ,  Heiner Glombik

IPC: C07C229/08 ,  C07C229/12

CPC classification number: C07C233/18 ,  C07D205/08

Abstract: The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.

Abstract translation: 本发明涉及式1的化合物及其生理上可接受的盐。 该化合物例如可用作降血脂药物。

公开(公告)号：US07666848B2

公开(公告)日：2010-02-23

申请号：US11464338

申请日：2006-08-14

Applicant: Heiner Glombik ,  Wendelin Frick ,  Hubert Heuer ,  Werner Kramer ,  Harm Brummerhop ,  Oliver Plettenburg

Inventor： Heiner Glombik ,  Wendelin Frick ,  Hubert Heuer ,  Werner Kramer ,  Harm Brummerhop ,  Oliver Plettenburg

IPC: A61K31/70 ,  C07H17/00

CPC classification number: A61K45/06 ,  A61K31/7042 ,  C07H17/00 ,  A61K2300/00

Abstract: Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.

Abstract translation: 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。

公开(公告)号：US20100035834A1

公开(公告)日：2010-02-11

申请号：US12465883

申请日：2009-05-14

Applicant: Heiner Glombik ,  Wendelin Frick ,  Stefan Theis ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer

Inventor： Heiner Glombik ,  Wendelin Frick ,  Stefan Theis ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer

IPC: A61K31/7028 ,  C07H5/06 ,  A61P25/00 ,  A61P3/10 ,  A61P25/28 ,  A61P25/18

CPC classification number: C07H5/06 ,  C07D409/12

Abstract: This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.

Abstract translation: 本发明涉及具有改进性质的新型1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。

公开(公告)号：US07176194B2

公开(公告)日：2007-02-13

申请号：US10463807

申请日：2003-06-18

Applicant: Gerhard Jaehne ,  Wendelin Frick ,  Stefanie Flohr ,  Andreas Lindenschmidt ,  Heiner Glombik ,  Werner Kramer ,  Hubert Heuer ,  Hans-Ludwig Schaefer

Inventor： Gerhard Jaehne ,  Wendelin Frick ,  Stefanie Flohr ,  Andreas Lindenschmidt ,  Heiner Glombik ,  Werner Kramer ,  Hubert Heuer ,  Hans-Ludwig Schaefer

IPC: C07D205/08 ,  C07D227/00 ,  A61K31/397 ,  A61P3/06 ,  A61P9/10

CPC classification number: C07D403/12 ,  C07D205/08 ,  C07D453/02 ,  C07D487/08 ,  Y10S930/28

Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.

Abstract translation: 本发明的一个实施方案涉及式I化合物，其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。

公开(公告)号：US07176193B2

公开(公告)日：2007-02-13

申请号：US10463388

申请日：2003-06-18

Applicant: Gerhard Jaehne ,  Wendelin Frick ,  Stefanie Flohr ,  Andreas Lindenschmidt ,  Heiner Glombik ,  Werner Kramer ,  Hubert Heuer ,  Hans-Ludwig Schaefer

Inventor： Gerhard Jaehne ,  Wendelin Frick ,  Stefanie Flohr ,  Andreas Lindenschmidt ,  Heiner Glombik ,  Werner Kramer ,  Hubert Heuer ,  Hans-Ludwig Schaefer

IPC: C07D205/08 ,  C07D227/00 ,  A61K31/397 ,  A61P3/06 ,  A61P9/10

CPC classification number: C07D205/08

Abstract: One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula 1, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.

Abstract translation: 本发明的一个实施方案涉及式I化合物：其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义。 本发明的其它实施方案涉及式1化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。

公开(公告)号：US07101856B2

公开(公告)日：2006-09-05

申请号：US10616945

申请日：2003-07-11

Applicant: Heiner Glombik ,  Wendelin Frick ,  Hubert Heuer ,  Werner Kramer ,  Harm Brummerhop ,  Oliver Plettenburg

Inventor： Heiner Glombik ,  Wendelin Frick ,  Hubert Heuer ,  Werner Kramer ,  Harm Brummerhop ,  Oliver Plettenburg

IPC: A61K31/70 ,  C07H17/00

CPC classification number: A61K45/06 ,  A61K31/7042 ,  C07H17/00 ,  A61K2300/00

Abstract: Novel thiophene glycoside derivatives of the formula I: in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.

Abstract translation: 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理上耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。