公开(公告)号：US20080078405A1

公开(公告)日：2008-04-03

申请号：US11541297

申请日：2006-09-29

Applicant: Gary L. Crumback ,  Charles E. Porges ,  Alfred Chung ,  David Hyde

Inventor： Gary L. Crumback ,  Charles E. Porges ,  Alfred Chung ,  David Hyde

IPC: A62B9/06 ,  A61M16/00

CPC classification number: A61M16/04 ,  A61M16/0427 ,  A61M16/0431 ,  A61M16/0443 ,  A61M16/0459 ,  A61M16/0463 ,  A61M16/0484 ,  A61M2205/0266

Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.

公开(公告)号：US4115374A

公开(公告)日：1978-09-19

申请号：US795497

申请日：1977-05-10

Applicant: James Walter Ryan ,  Alfred Chung

Inventor： James Walter Ryan ,  Alfred Chung

IPC: C07K5/083 ,  C07K5/097 ,  C12Q1/34 ,  C12Q1/37 ,  C07C103/52

CPC classification number: C07K5/0823 ,  C07K5/0806 ,  C12Q1/34 ,  C12Q1/37 ,  G01N2333/948 ,  G01N2333/96486

Abstract: The novel compounds Iodo-p-hydroxyphenyl-glycylglycylglycine and Benzoylprolylphenylalanylarginine are disclosed, together with radioisotope labeled forms thereof, wherein the radioisotope is incorporated in the Iodo-p-hydroxyphenyl moiety or the Benzoyl moiety, respectively. These compounds are useful as substrates for angiotensin converting enzyme in an assay for that enzyme's activity.

Abstract translation: 公开了新型化合物Ioo-对羟基苯基 - 甘氨酰甘氨酰甘氨酸和苯甲酰基脯氨酰基苯丙氨酰精氨酸及其放射性同位素标记形式，其中放射性同位素分别并入碘代对羟基苯基部分或苯甲酰基部分。 这些化合物在该酶的活性测定中可用作血管紧张素转换酶的底物。

公开(公告)号：US08413659B2

公开(公告)日：2013-04-09

申请号：US12849636

申请日：2010-08-03

Applicant: Gary L. Crumback ,  Charles E. Porges ,  Alfred Chung ,  David Hyde

Inventor： Gary L. Crumback ,  Charles E. Porges ,  Alfred Chung ,  David Hyde

IPC: A61M16/00 ,  A62B9/06

CPC classification number: A61M16/04 ,  A61M16/0427 ,  A61M16/0431 ,  A61M16/0443 ,  A61M16/0459 ,  A61M16/0463 ,  A61M16/0484 ,  A61M2205/0266

Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.

Abstract translation: 公开了一种气管内管，其具有最小的横截面轮廓，以便于在插管期间容易地观察解剖特征。 在将管置于气管中之后，管适于增加直径。 以这种方式，管直径可以被扩张以允许减少患者的呼吸作用（WOB），而没有如此大的直径导致气管不适。

公开(公告)号：US20100313895A1

公开(公告)日：2010-12-16

申请号：US12859567

申请日：2010-08-19

Applicant: Michael P. O'Neil ,  Joel C. Colburn ,  Gary L. Crumback ,  Charles E. Porges ,  Alfred Chung ,  David Hyde

Inventor： Michael P. O'Neil ,  Joel C. Colburn ,  Gary L. Crumback ,  Charles E. Porges ,  Alfred Chung ,  David Hyde

IPC: A61M16/04 ,  B23P17/04

CPC classification number: A61M16/04 ,  A61M16/0427 ,  A61M16/0431 ,  A61M16/0434 ,  A61M16/044 ,  A61M16/0443 ,  A61M16/0459 ,  A61M16/0463 ,  A61M16/0484 ,  A61M25/0026 ,  A61M2205/0266 ,  Y10T29/49826

Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.

Abstract translation: 公开了一种气管内管，其具有最小的横截面轮廓，以便于在插管期间容易地观察解剖特征。 在将管置于气管中之后，管适于增加直径。 以这种方式，管直径可以被扩张以允许减少患者的呼吸作用（WOB），而没有如此大的直径导致气管不适。

公开(公告)号：US20080050736A1

公开(公告)日：2008-02-28

申请号：US11718831

申请日：2005-11-09

Applicant: Stanley Stevens ,  Alfred Chung

Inventor： Stanley Stevens ,  Alfred Chung

IPC: C12Q1/68 ,  G01N24/00 ,  G01N33/53

CPC classification number: G01N33/533 ,  C07D493/10 ,  C07H21/04 ,  G01N33/582 ,  Y10T436/24

Abstract: The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by addition of cysteamine as the target-associative moiety to another molecule or entity having a property or properties useful in discriminating or selecting between members of a set, where such properties could include, for example, fluorescence, mass, affinity, reactivity, size, absorbance, magnetism, subatomic spin characteristics, or an ability to associate specifically or preferentially with certain structures. The invention further relates to a method for analyzing, identifying, or purifying phosphorylated proteins or phosphorylated protein fragments using a tag having the properties of both fluorescence and affinity.

Abstract translation: 本发明涉及包含半胱胺作为靶缔合部分的靶标相关标签。 本发明还涉及通过将半胱胺作为靶缔合部分加入另一分子或实体来生产目标缔合标签的方法，所述另一分子或实体具有可用于区分或选择组中成员之间的特性或性质，其中这些性质可包括 ，例如荧光，质量，亲和力，反应性，大小，吸光度，磁性，亚原子自旋特性，或特定或优先与特定结构缔合的能力。 本发明还涉及使用具有荧光和亲和性两者的标签来分析，鉴定或纯化磷酸化蛋白质或磷酸化蛋白片段的方法。