公开(公告)号：US09877691B2

公开(公告)日：2018-01-30

申请号：US15398116

申请日：2017-01-04

Applicant: Straxcorp Pty Ltd

Inventor： Roger Zebaze ,  Eleanor Jean Mackie ,  Anne Bohte ,  Aloys Mbala ,  Ali Ghasemzadeh ,  Ego Seeman

IPC: G06K9/00 ,  A61B6/00 ,  G06T7/00 ,  A61B6/03 ,  G06T11/00 ,  G06T7/70 ,  G06T7/12

CPC classification number: A61B6/505 ,  A61B6/032 ,  A61B6/5205 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/70 ,  G06T11/003 ,  G06T2200/24 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/20104 ,  G06T2207/30008 ,  G06T2207/30096

Abstract: A method for quantifying the effects of a treatment of a subject, comprising: analyzing a sample of the subject, the sample comprising a material of interest and at least one adjacent material that is generally adjacent to the material of interest, the material of interest having a generally different density from the adjacent material. The analyzing comprises: (i) automatically defining a plurality of regions of interest within an image of the sample that includes a junction between the material of interest and the adjacent material, each of said regions of interest having a width of one or more pixels or voxels; (ii) determining respective profiles of density, intensity or attenuation within the regions of interest, each of the respective profiles crossing the junctions between the material of interest and the adjacent material; (iii) automatically identifying the material of interest in the profiles; (iv) analyzing said profiles by automatically defining, for each of said profiles, a series of sections of said respective profile, each of said sections comprising at least one S-like portion of the respective profile, the S-like portion containing the junction between the material of interest and the adjacent material; and (v) locating the junction in each of the S-like portions, including: (a) identifying the greatest difference in values of the respective profile between an adjacent peak and trough in a segment of the respective profile that includes at least some of the material of interest and at least some of the adjacent material; and (b) locating a point of inflexion in said segment. This method may also be employed in a method of treatment of a disease in a subject.

公开(公告)号：US20170119333A1

公开(公告)日：2017-05-04

申请号：US15398116

申请日：2017-01-04

Applicant: Straxcorp Pty Ltd

Inventor： Roger ZEBAZE ,  Eleanor Jean MACKIE ,  Anne BOHTE ,  Aloys MBALA ,  Ali GHASEMZADEH ,  Ego SEEMAN

IPC: A61B6/00 ,  A61B6/03

CPC classification number: A61B6/505 ,  A61B6/032 ,  A61B6/5205 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/70 ,  G06T11/003 ,  G06T2200/24 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/20104 ,  G06T2207/30008 ,  G06T2207/30096

Abstract: A method for quantifying the effects of a treatment of a subject, comprising: analysing a sample of the subject, the sample comprising a material of interest and at least one adjacent material that is generally adjacent to the material of interest, the material of interest having a generally different density from the adjacent material. The analysing comprises: (i) automatically defining a plurality of regions of interest within an image of the sample that includes a junction between the material of interest and the adjacent material, each of said regions of interest having a width of one or more pixels or voxels; (ii) determining respective profiles of density, intensity or attenuation within the regions of interest, each of the respective profiles crossing the junctions between the material of interest and the adjacent material; (iii) automatically identifying the material of interest in the profiles; (iv) analysing said profiles by automatically defining, for each of said profiles, a series of sections of said respective profile, each of said sections comprising at least one S-like portion of the respective profile, the S-like portion containing the junction between the material of interest and the adjacent material; and (v) locating the junction in each of the S-like portions, including: (a) identifying the greatest difference in values of the respective profile between an adjacent peak and trough in a segment of the respective profile that includes at least some of the material of interest and at least some of the adjacent material; and (b) locating a point of inflexion in said segment. This method may also be employed in a method of treatment of a disease in a subject.

公开(公告)号：US20160296188A1

公开(公告)日：2016-10-13

申请号：US15191079

申请日：2016-06-23

Applicant: StraxCorp Pty Ltd

Inventor： Roger ZEBAZE ,  Eleanor Jean MACKIE ,  Anne BOHTE ,  Aloys MBALA ,  Ali GHASEMZADEH ,  Ego SEEMAN

IPC: A61B6/00 ,  G06T7/00 ,  A61B6/03 ,  G06T11/00

CPC classification number: A61B6/505 ,  A61B6/032 ,  A61B6/5205 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/70 ,  G06T11/003 ,  G06T2200/24 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/20104 ,  G06T2207/30008 ,  G06T2207/30096

Abstract: A computer-implemented system and method for analysing a sample comprising a material of interest and at least first and second adjacent materials each generally adjacent to the material of interest, the material of interest having a generally different density from the at least first and second adjacent materials. The method comprises automatically defining a plurality of regions of interest within an image of the sample that includes a junction between the material of interest and the first adjacent material and a junction between the material of interest and the second adjacent material, each of the regions of interest having a width of one or more pixels or voxels; determining respective profiles of density, intensity or attenuation within the regions of interest, each of the respective profiles crossing the respective junctions; automatically identifying the material of interest in the density profile; analysing the profiles by automatically defining, for each of the profiles, a series of sections of the respective profile, each of the sections comprising at least first and second S-like portions of the respective profile, the first portion containing the junction between the material of interest and the first adjacent material, the second portion containing the junction between the material of interest and the second adjacent material; and locating the junction in each of the first portions, including: identifying the greatest difference in values of the respective profile between an adjacent peak and trough in a segment of the respective profile that includes at least some of the material of interest and at least some of the first adjacent material; and locating a point of inflexion in the segment.

Abstract translation: 一种用于分析样品的计算机实现的系统和方法，所述样品包括感兴趣的材料和至少第一和第二相邻材料，每个材料通常与感兴趣的材料相邻，感兴趣的材料具有与至少第一和第二相邻 材料 该方法包括在样本的图像内自动定义多个感兴趣区域，该多个区域包括感兴趣的材料和第一相邻材料之间的连接点以及感兴趣材料和第二相邻材料之间的连接点，每个区域 兴趣具有一个或多个像素或体素的宽度; 确定感兴趣区域内的密度，强度或衰减的各个轮廓，各个轮廓中的每一个与相应的交叉点交叉; 自动识别密度分布中感兴趣的材料; 通过为每个轮廓自动定义相应轮廓的一系列部分来分析轮廓，每个部分包括相应轮廓的至少第一和第二S形部分，第一部分包含材料之间的连接部 感兴趣的和第一相邻材料，第二部分包含感兴趣的材料和第二相邻材料之间的连接点; 以及将所述结点定位在所述第一部分中的每一个中，包括：识别所述相应轮廓的段中的相邻峰和波谷之间的相应轮廓的值中的最大差值，所述相关轮廓包括至少一些所述材料和至少一些 的第一相邻材料; 并在分段中定位拐点。