公开(公告)号：US20190177287A1

公开(公告)日：2019-06-13

申请号：US16278778

申请日：2019-02-19

申请人： ADVERIO PHARMA GMBH

发明人： Peter FEY ,  Alfons Grunenberg ,  Donald Bierer

IPC分类号： C07D295/104 ,  A61P9/00 ,  C07D471/04 ,  C07D295/067 ,  C07D265/30 ,  C07C317/04 ,  C07C309/04 ,  C07C303/28

摘要： The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US10030014B2

公开(公告)日：2018-07-24

申请号：US14295922

申请日：2014-06-04

申请人： Adverio Pharma GmbH

发明人： Franz-Josef Mais ,  Joachim Rehse ,  Winfried Joentgen ,  Konrad Siegel

IPC分类号： C07D239/48 ,  C07D239/50 ,  C07D471/04 ,  C07D487/04 ,  C07D403/04 ,  C07C325/02

摘要： The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.

公开(公告)号：US09604948B2

公开(公告)日：2017-03-28

申请号：US14796703

申请日：2015-07-10

申请人： ADVERIO PHARMA GMBH

发明人： Peter Fey ,  Alfons Grunenberg ,  Donald Bierer

IPC分类号： A01N43/54 ,  C07D295/104 ,  C07D265/30 ,  C07D471/04 ,  C07C309/04 ,  C07C317/04 ,  C07D295/067 ,  C07C303/28

CPC分类号： C07D295/104 ,  C07B2200/13 ,  C07C303/28 ,  C07C309/04 ,  C07C317/04 ,  C07D265/30 ,  C07D295/067 ,  C07D471/04 ,  C07C309/65

摘要： The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.