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    Bicyclic compounds for diagnosis and therapy
    31.
    发明授权
    Bicyclic compounds for diagnosis and therapy 有权

    公开(公告)号：US11623931B2

    公开(公告)日：2023-04-11

    申请号：US16894682

    申请日：2020-06-05

    Applicant: AC IMMUNE SA

    Inventor： Jérôme Molette ,  Emanuele Gabellieri ,  Vincent Darmency

    IPC: C07D495/04 ,  C07D417/14 ,  C07D513/04 ,  A61K51/04 ,  C07B59/00

    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity, of a group of disorders and abnormalities associated with alpha-synuclein (α-synuclein, A-synuclein, aSynuclein, A-syn, α-syn, aSyn) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease. The instant compounds are particularly useful in determining a predisposition to such a disorder, monitoring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament. The present compounds can also be used to treat, alleviate or prevent a disorder or abnormality associated with alpha-synuclein aggregates.

    Micro-Radiobinding Assays for Ligand Screening
    32.
    发明申请
    Micro-Radiobinding Assays for Ligand Screening 有权

    公开(公告)号：US20220397577A1

    公开(公告)日：2022-12-15

    申请号：US17642800

    申请日：2020-09-30

    Applicant: AC Immune SA

    Inventor： Luigino Grasso

    IPC: G01N33/60 ,  G01N33/68

    Abstract: The disclosure relates to binding assays that can measure the binding of ligands to a specific protein target in a micro-radiobinding assay. In particular, the present disclosure relates micro-radiobinding assays useful for low-abundance proteins, such as recombinant or tissue-derived proteins isolated from healthy or diseased, human donor samples.

    NOVEL COMPOUNDS FOR DIAGNOSIS
    34.
    发明申请
    NOVEL COMPOUNDS FOR DIAGNOSIS 有权

    公开(公告)号：US20210252175A1

    公开(公告)日：2021-08-19

    申请号：US16973329

    申请日：2019-06-07

    Applicant: AC IMMUNE SA

    Inventor： Jérôme MOLETTE

    IPC: A61K51/04 ,  C07D513/04 ,  C07B59/00 ,  A61P25/28 ,  G01N33/68

    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity of a group of disorders and abnormalities associated with alpha-synuclein (α-synuclein, A-synuclein, aSynuclein, a-synuclein, A-syn, α-syn, aSyn, SNCA, Non-amyloid beta component of Alzheimer's disease (AD) amyloid plaques, Non-A4 component of amyloid precursor, NACP) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease (PD). The instant compounds are particularly useful in the diagnosis of the preclinical state of such a disorder, monitoring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament.

    ANTI-ABETA THERAPEUTIC VACCINES
    38.
    发明申请
    ANTI-ABETA THERAPEUTIC VACCINES 审中-公开

    公开(公告)号：US20190307867A1

    公开(公告)日：2019-10-10

    申请号：US16379322

    申请日：2019-04-09

    Applicant: AC Immune SA

    Inventor： Emma Fiorini ,  Marija Vukicevic Verhille ,  Maria Pihlgren Bosch

    IPC: A61K39/00 ,  A61K9/127 ,  A61K39/39 ,  A61K39/05 ,  A61K39/08 ,  A61K39/245

    Abstract: A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.

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