公开(公告)号：US10914658B2

公开(公告)日：2021-02-09

申请号：US16868715

申请日：2020-05-07

申请人： Agilent Technologies, Inc.

发明人： Kyle Schleifer ,  Kristin Briana Bernick ,  Adrienne Mccampbell ,  Nicholas M. Sampas ,  Victor Lim

IPC分类号： G01N1/30 ,  G01N1/06 ,  G01N1/28 ,  G01N35/00 ,  G06T7/00

摘要： The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.

公开(公告)号：US20210025789A1

公开(公告)日：2021-01-28

申请号：US16935191

申请日：2020-07-22

申请人： JelloX Biotech Inc.

发明人： YEN-YIN LIN ,  YU-CHIEH LIN ,  CHIA-JUNG LEE

IPC分类号： G01N1/06 ,  G01N1/28

摘要： The disclosure provides a tissue sectioning system for direct coupling with a microscope. The tissue sectioning system includes a frame having a blade module, a container containing a solution system, and a movable arm. Specifically, the blade module is used to slice a sample. The solution system in the container includes at least two solutions, which are the first and second solutions. Further, a refractive index of the first and second solutions is identical, and the first and second solution is immiscible with each other. The first moveable arm has two ends, which are the first end and second ends. The first and second ends connect to the container and the frame, respectively. Additionally, the first moveable arm moves the container along the Z-axis.

公开(公告)号：US10901202B2

公开(公告)日：2021-01-26

申请号：US16573449

申请日：2019-09-17

申请人： Illumina, Inc.

发明人： Stanley S. Hong ,  William McGuigan ,  Frank DeWitt, IV

IPC分类号： G02B26/08 ,  G01N1/06

摘要： A system includes: a light source; first and second gratings; and at least one reflective component that in a first position forms a first light path originating at the light source and extending to the first grating and thereafter to a subsequent component in the system, and that in a second position forms a second light path originating at the light source and extending to the second grating and thereafter to the subsequent component.

公开(公告)号：US20200307012A1

公开(公告)日：2020-10-01

申请号：US16765510

申请日：2018-11-27

申请人： Leica Microsystems Ltd., Shanghai

发明人： Zheguang FAN ,  Xiang LIANG ,  Gang ZHOU

IPC分类号： B26D7/06 ,  G01N1/06

摘要： A retraction device includes a spindle movable along the axis thereof and an operating unit including a pull rod and a movable member. The movable member defines a step-shaped groove, the pull rod has a first end connected to the spindle, and a second end received in the groove; the groove includes a first step and a second step and an inclined face connecting the first step and the second step arranged along a first direction, and a height of the second step is greater than that of the first step along the axis direction of the spindle; the movable member is slidable along the first direction relative to the pull rod, to allow the spindle to switch between a retraction position in which the pull rod is received in the second step, and a release position in which the pull rod is received in the first step.

公开(公告)号：US20200064232A1

公开(公告)日：2020-02-27

申请号：US16671385

申请日：2019-11-01

申请人： Clarapath, Inc.

发明人： Partha P. Mitra ,  Alexander S. Tolpygo ,  Robert L. Kleinberg

IPC分类号： G01N1/06

摘要： A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.

公开(公告)号：US20200041387A1

公开(公告)日：2020-02-06

申请号：US16367141

申请日：2019-03-27

申请人： 3Scan, Inc.

发明人： Christopher Rhodes ,  Cody Daniel ,  Joey Springer ,  Kristy Parker

IPC分类号： G01N1/06 ,  G01N1/30

摘要： An automated tissue section slicing, staining, and imaging system sequentially adheres tissue sections to a continuous substrate such that the staining, imaging, and interpretation of the tissue sections are readily carried out at high speed under machine control.

公开(公告)号：US10520398B2

公开(公告)日：2019-12-31

申请号：US14991631

申请日：2016-01-08

申请人： Leica Mikrosysteme GmbH

发明人： Reinhard Lihl ,  Michael Zimmermann

IPC分类号： G01N1/06 ,  B26D1/10 ,  B26D1/00 ,  G01N1/42 ,  B26D1/157

摘要： A microtome system has a cryomicrotome with a sectioning device in which is provided a preparation holder and a knife edge that are guided past one another inside a working space during a sectioning operation, in order to produce thin sections of a preparation retained in the preparation holder. A micromanipulator is operable outside the working space. With the micromanipulator, a tool for retention of a specimen support is positioned proximate the knife edge during a sectioning operation in order to receive the sections that are produced, preferably for substantially stationary retention of the specimen support.

公开(公告)号：US10466143B2

公开(公告)日：2019-11-05

申请号：US15811464

申请日：2017-11-13

申请人： Sakura Finetek U.S.A., Inc.

发明人： Xuan S. Bui ,  Alyicia Marie Rios ,  Erico Von Bueren

IPC分类号： G01N1/06 ,  B26D7/01 ,  B26D7/27 ,  H05B33/08 ,  G01N1/31 ,  G01N21/25

摘要： A microtome including a microtome housing having a base portion, a front portion and a top portion, a microtome storage member associated with the top portion of the microtome housing, and a sample sectioning assembly associated with the front portion of the microtome housing, the sample sectioning assembly operable to cut sections from a sample.

公开(公告)号：US20190242790A1

公开(公告)日：2019-08-08

申请号：US15890829

申请日：2018-02-07

申请人： Nanotronics Imaging, Inc.

发明人： Matthew C. Putman ,  John B. Putman ,  Alejandro S. Jaime ,  Randolph E. Griffith

IPC分类号： G01N1/06

CPC分类号： G01N1/06 ,  G01N1/2813

摘要： Cutting apparatuses comprising: a base; a first platen and a second platen that are coupled to the base and that are configured to hold a specimen, wherein the first platen includes a first cutting surface and the second platen includes a second cutting surface; a moveable carriage that is moveably coupled to the base; a cutting arm that is pivotably coupled at a pivot point to the carriage and that is configured to hold a cutting blade; and a spring coupled to the arm so as to apply a directional force to the arm and the blade, wherein the moveable carriage can be moved in a manner that causes the blade to slide on at least one of the first cutting surface and the second cutting surface while being pressed against the at least one of the first cutting surface and the second cutting surface by the directional force.

公开(公告)号：US10281365B2

公开(公告)日：2019-05-07

申请号：US16150910

申请日：2018-10-03

申请人： Aquaro Histology, Inc.

发明人： Collin Rich ,  Nolan Orfield ,  Vincent Alessi

IPC分类号： G01N1/10 ,  G01N1/00 ,  G01N1/36 ,  G01N1/31 ,  G01N1/28 ,  G01N1/06 ,  G01N1/44

摘要： A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby recirculating fluid flow between the fluid channel inlet and the fluid channel outlet to carry sections between the sample sectioning module and the section mounting region.