公开(公告)号：US08791409B2

公开(公告)日：2014-07-29

申请号：US13560303

申请日：2012-07-27

Applicant: Alexander Alekseevich Makarov ,  Eduard V. Denisov ,  Nicolaie Eugen Damoc

Inventor： Alexander Alekseevich Makarov ,  Eduard V. Denisov ,  Nicolaie Eugen Damoc

IPC: H01J49/04 ,  H01J49/40 ,  H01J49/00 ,  H01J49/02

CPC classification number: H01J49/005 ,  H01J49/004 ,  H01J49/027 ,  H01J49/406

Abstract: A method for mass analyzing multiply-charged ions is provided as well as a mass analyzer suitable for performing the method, the method comprising: introducing multiply-charged ions into an electrostatic mass analyzer where ions undergo multiple changes of direction of motion; detecting the ions in the analyzer; and determining the mass-to-charge ratio of at least some of the detected ions; wherein the absolute velocity in the analyzer of at least some of the ions whose mass-to-charge ratio is determined is not greater than 8,000 m/s and the average path length over the duration of detection of such ions is longer than required for detecting such ions with a mass-to-charge ratio resolving power of 1,000. High resolution mass spectra of high m/z protein complexes, for example in a native state and with low charge, can be achieved.

Abstract translation: 本发明提供了一种质量分析多电荷离子的方法以及适用于执行该方法的质量分析器，该方法包括：将多电荷离子引入静电质量分析器，其中离子经过多个运动方向的改变; 检测分析仪中的离子; 以及确定所检测的离子中的至少一些的质荷比; 其中确定质荷比的至少一些离子的分析仪中的绝对速度不大于8,000m / s，并且在这种离子的检测持续时间内的平均路径长度比检测所需的时间长 这种离子的质荷比分辨能力为1,000。 可以实现高m / z蛋白复合物的高分辨率质谱，例如在天然状态和低电荷下。

公开(公告)号：US20130313425A1

公开(公告)日：2013-11-28

申请号：US13976218

申请日：2011-12-29

Applicant: Anatoly N. Verenchikov

Inventor： Anatoly N. Verenchikov

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0031 ,  H01J49/027 ,  H01J49/06 ,  H01J49/406 ,  H01J49/4205 ,  H01J49/4245 ,  H01J49/4255

Abstract: A method of mass spectral analysis in an analytical electrostatic trap (14) is disclosed. The electrostatic trap (14) defines an electrostatic field volume and includes trap electrodes having static and non-ramped potentials. The method comprises injecting a continuous ion beam into the electrostatic field volume.

Abstract translation: 公开了一种分析静电阱（14）中的质谱分析方法。 静电捕获器（14）限定静电场容积并且包括具有静态和非斜坡电位的陷阱电极。 该方法包括将连续离子束注入到静电场容积中。

公开(公告)号：US07514675B2

公开(公告)日：2009-04-07

申请号：US11730621

申请日：2007-04-03

Applicant: Shinichi Yamaguchi

Inventor： Shinichi Yamaguchi

IPC: H01J49/40

CPC classification number: H01J49/004 ,  H01J49/027 ,  H01J49/408

Abstract: The present invention provides a single set of mass spectrometer capable of selectively performing the following two modes of analyses according to the purpose of analysis: the first mass spectrometry mode in which the analysis can be repeated at short intervals of time; and the second mass spectrometry mode in which the analysis can be performed with high mass resolution and high accuracy. In an embodiment of the present invention, ions ejected from an ion source 1 travel along a straight path B, on which gate electrodes 3 are provided. When a voltage is applied from an MS mode selection controller 7 to the gate electrodes 3, the ions are introduced into a loop orbit A. Located on the loop orbit A is a second ion detector 6, which is a nondestructive type of ion detector. Detection signals of the second ion detector 6 are sent to a data processor 9, which extracts flight time spectrum data from those signals and Fourier-transforms those data to convert the time axis to a frequency axis. From the frequency spectrum thus created, the mass-to-charge ratio of each ion is calculated with high accuracy. When no voltage is applied to the gate electrodes 3, the ions ejected from the ion source 1 travel along the straight path B and arrive at a first ion detector 5. This mode of analysis requires only a short period of time and can achieve a high level of time resolution.

Abstract translation: 本发明提供了一组能够根据分析目的选择性地执行以下两种分析模式的质谱仪：第一种质谱模式，其中可以在短时间间隔内重复分析; 以及可以以高质量分辨率和高精度进行分析的第二质谱模式。 在本发明的一个实施例中，从离子源1喷出的离子沿着设置有栅电极3的直线路径B行进。 当从MS模式选择控制器7将电压施加到栅极电极3时，离子被引入环路轨道A.位于环路轨道A上的是第二离子检测器6，其是非破坏性的离子检测器。 第二离子检测器6的检测信号被发送到数据处理器9，数据处理器9从这些信号中提取飞行时间频谱数据，并对这些数据进行傅立叶变换，以将时间轴转换为频率轴。 根据这样产生的频谱，以高精度计算各离子的质荷比。 当没有电压施加到栅电极3时，从离子源1喷出的离子沿着直线路径B行进并到达第一离子检测器5.这种分析方式仅需要很短的时间并且可以达到高 时间分辨率。

公开(公告)号：US20090084949A1

公开(公告)日：2009-04-02

申请号：US12037506

申请日：2008-02-26

Applicant: Jochen Franzen ,  Karsten Michelmann

Inventor： Jochen Franzen ,  Karsten Michelmann

IPC: B01D59/44

CPC classification number: H01J49/42 ,  H01J49/0036 ,  H01J49/027

Abstract: The invention relates to mass spectrometers in which ion clouds are stored in two spatial directions by radial forces while oscillating largely harmonically at a mass-specific frequency in a third spatial direction perpendicular to the other two, in a potential minimum, the shape of which is as close to a parabola as possible. Analysis of the oscillation frequencies of these ion clouds, preferably by a Fourier analysis, leads via a frequency spectrum to a mass spectrum. The frequency spectrum is analyzed to identify false signals in the frequency spectrum as harmonics and eliminating them where necessary.

Abstract translation: 本发明涉及质谱仪，其中离子云通过径向力在两个空间方向上存储，同时以与另外两个垂直的第三空间方向上的质量特定频率大量谐波地振荡，其形状为 尽可能接近抛物线。 这些离子云的振荡频率的分析优选通过傅立叶分析，经由频谱到质谱。 分析频谱以将频谱中的伪信号作为谐波识别，并在必要时消除它们。

公开(公告)号：US20050045817A1

公开(公告)日：2005-03-03

申请号：US10929770

申请日：2004-08-31

Applicant: Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda ,  Daisuke Okumura

Inventor： Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda ,  Daisuke Okumura

IPC: G01N27/62 ,  B01D59/44 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40

CPC classification number: H01J49/408 ,  H01J49/027

Abstract: In a time of flight mass spectrometer (TOF-MS) of the present invention, a flight controller makes ions fly a loop orbit a predetermined number of turns, and an ion detector detects the ions at each turn of the flight. A flight time measurer measures the length of flight time of ions of a same mass to charge ratio at every turn, and a data processor constructs a spectrum of flight time. The data processor further computes the Fourier transformation of the spectrum, and determines the mass to charge ratio of the ions based on a frequency peak appearing in the Fourier transformation.

Abstract translation: 在本发明的飞行时间质谱仪（TOF-MS）中，飞行控制器使离子飞行预定匝数的环路轨道，并且离子检测器在飞行的每一回合处检测离子。 飞行时间测量器可以测量每一回合具有相同质荷比的离子的飞行时间长度，并且数据处理器构建飞行时间谱。 数据处理器进一步计算光谱的傅立叶变换，并且基于在傅里叶变换中出现的频率峰值来确定离子的质荷比。

公开(公告)号：US20020190205A1

公开(公告)日：2002-12-19

申请号：US09881576

申请日：2001-06-14

Inventor： Melvin A. Park

IPC: H01J049/42

CPC classification number: H01J49/4225 ,  H01J49/027

Abstract: A means and method whereby ions from an ion source can be selected and transferred via a multipole analyzer system in such a way that ions are trapped and analyzed by inductive detection. Ions generated at an elevated pressure are transferred by a pump and capillary system into a multipole device. The multipole device is composed of one analyzing section with two trapping sections at both sides. When the proper voltages are applied, the trapping sections trap ions within the analyzing region. The ions are then detected by two sets of detection electrodes.

Abstract translation: 可以通过多极分析仪系统选择和转移来自离子源的离子的​​方法和方法，使得通过感应检测捕获和分析离子。 在高压下产生的离子通过泵和毛细管系统转移到多极装置中。 多极装置由一个分析部分组成，两侧具有两个捕集部分。 当施加适当的电压时，捕获部分捕获分析区域内的离子。 然后通过两组检测电极检测离子。

公开(公告)号：US20020190200A1

公开(公告)日：2002-12-19

申请号：US09883841

申请日：2001-06-18

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Daniel Zajfman ,  Oded Heber ,  Henrik B. Pedersen ,  Yinon Rudich ,  Irit Sagi ,  Michael Rappaport

IPC: H01J049/40

CPC classification number: H01J3/40 ,  H01J49/027 ,  H01J49/406 ,  H01J49/4245

Abstract: A method for trapping of a plurality of charged particles in a charged particle trap. The trap includes first and second electrode mirrors having a common optical axis, the mirrors being arranged in alignment at two extremities thereof. The mirrors are capable, when voltage is applied thereto, of creating respective electric fields defined by key field parameters. The electric fields are configured to reflect charged particles causing their oscillation between the mirrors. The method includes introducing into the trap, along the optical axis, the plurality of charged particles as a beam having pre-determined key beam parameters. The method further includes choosing the key field parameters for at least one of the mirrors such as to induce bunching among charged particles in the beam.

Abstract translation: 一种用于在带电粒子阱中捕获多个带电粒子的方法。 该陷阱包括具有共同的光轴的第一和第二电极反射镜，该反射镜在两端配置成对准。 当施加电压时，反射镜能够产生由关键场参数定义的各个电场。 电场被配置为反射带电粒子，导致它们在反射镜之间振荡。 该方法包括沿着光轴将多个带电粒子作为具有预定的键束参数的光束引入陷阱。 该方法还包括为至少一个反射镜选择关键场参数，以便在光束中的带电粒子之间引起聚束。

公开(公告)号：US20240297030A1

公开(公告)日：2024-09-05

申请号：US18567195

申请日：2021-07-15

Applicant: SHIMADZU CORPORATION

Inventor： Sergey SMIRNOV ,  Li DING ,  Aleksandr RUSINOV

IPC: H01J49/00 ,  H01J49/02

CPC classification number: H01J49/0036 ,  H01J49/027

Abstract: A method of processing an image-charge/current signal representative of one or more ions undergoing oscillatory motion within an ion analyser apparatus. The method comprising obtaining a recording of the image-charge/current signal generated by the ion analyser apparatus in the time domain. By a signal processing unit, the method comprises determining a value for the period of a periodic signal component within the recorded signal. Then, the method includes truncating the recorded signal to provide a truncated signal having a duration substantially equal to an integer multiple of said period. A step of reconstructing a time-domain signal is done based on a selected one or more frequency-domain harmonic components of the truncated signal. Next, the method determines a magnitude of the reconstructed time-domain signal and therewith calculating a value representative of the charge of a said ion undergoing oscillatory motion within the ion analyser apparatus.

公开(公告)号：US20190035615A1

公开(公告)日：2019-01-31

申请号：US16072550

申请日：2017-03-22

Applicant: SHIMADZU CORPORATION

Inventor： Sergey SMIRNOV ,  Li DING ,  Aleksandr RUSINOV

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/02

CPC classification number: H01J49/0036 ,  H01J49/0004 ,  H01J49/0009 ,  H01J49/027 ,  H01J49/4245

Abstract: A method of processing an image charge/current signal representative of trapped ions undergoing oscillatory motion. The method includes: identifying a plurality of fundamental frequencies potentially present in the image charge/current signal based on an analysis of peaks in a frequency spectrum corresponding to the image charge/current signal in the frequency domain, wherein each candidate fundamental frequency falls in a frequency range of interest; deriving a basis signal for each candidate fundamental frequency using a calibration signal; and estimating relative abundances of ions corresponding to the candidate fundamental frequencies by mapping the basis signals to the image charge/current signal. At least one candidate fundamental frequency is calculated using a frequency associated with a peak that falls outside the frequency range of interest and that has been determined as representing a second or higher order harmonic of the candidate fundamental frequency.

公开(公告)号：US09899201B1

公开(公告)日：2018-02-20

申请号：US15346977

申请日：2016-11-09

Applicant: Bruker Daltonics, Inc.

Inventor： Melvin Andrew Park

IPC: H01J49/40 ,  H01J49/06 ,  H01J49/08 ,  H01J49/02

CPC classification number: H01J49/08 ,  H01J43/246 ,  H01J49/025 ,  H01J49/027 ,  H01J49/40

Abstract: The invention relates to the linear dynamic range of ion abundance measurement devices in mass spectrometers, such as time-of-flight mass spectrometers. The invention solves the problem of ion current peak saturation by producing a second ion measurement signal at an intermediate stage of amplification in a secondary electron multiplier, e.g. a signal generated between the two multichannel plates in chevron arrangement. Because saturation effects are observed only in later stages of amplification, the signal from the intermediate stage of amplification will remain linear even at high ion intensities and will remain outside saturation. In the case of a discrete dynode detector this could encompass, for example, placement of a detection grid between two dynodes near the middle of the amplification chain. The invention uses detection of the image current generated by the passing electrons.