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公开(公告)号：US11951165B2
公开(公告)日：2024-04-09
申请号：US16459303
申请日：2019-07-01
Applicant: Vaxcyte, Inc.
Inventor： Jeffery C. Fairman , Jon H. Heinrichs , Wei Chan
IPC: A61K39/385 , A61K39/09 , A61P31/04 , C07K14/00 , C07K14/285 , C07K14/33 , C07K14/34 , A61K38/00 , A61K39/00
CPC classification number: A61K39/385 , A61K39/092 , A61P31/04 , C07K14/001 , C07K14/285 , C07K14/33 , C07K14/34 , A61K38/00 , A61K2039/6037 , A61K2039/627 , A61K2039/70
Abstract: Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.
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公开(公告)号：US20240108738A1
公开(公告)日：2024-04-04
申请号：US18271353
申请日：2022-01-10
Applicant: Bicycle Tx Limited
Inventor： Nicholas KEEN , Gemma MUDD , Fay DUFORT , Katie GAYNOR , Liuhong CHEN , Phil BRANDISH , Cris LEITHEISER , Sandra UHLENBROICH , Liz REPASH , Kevin MCDONNELL
CPC classification number: A61K47/64 , A61P37/06 , C07K7/08 , C07K14/001 , A61K38/00
Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to natural killer (NK) cells. The invention also includes multimeric binding complexes comprising at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands or said multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by natural killer (NK) cells, such as inflammatory disorders, autoimmune disease and cancer.
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公开(公告)号：US20240101606A1
公开(公告)日：2024-03-28
申请号：US18316102
申请日：2023-05-11
Applicant: California Institute of Technology
Inventor： Lucy S. Chong , Ronghui Zhu , Xiaofei Ge , Michael B. Elowitz , Mark W. Budde
CPC classification number: C07K14/001 , C12N9/22
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
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公开(公告)号：US20240101605A1
公开(公告)日：2024-03-28
申请号：US18255215
申请日：2021-12-21
Applicant: AFFIBODY AB
Inventor： John LÖFBLOM , Stefan STÅHL , Jonas PERSSON , Olof ERIKSSON , Olov KORSGREN
IPC: C07K14/00
CPC classification number: C07K14/001 , C07K2319/20 , C07K2319/40
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for CD69 and provides a CD69-binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QK X21AFKX25X26LKD. The present disclosure also relates to the use of such a CD69-binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.
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公开(公告)号：US20240101604A1
公开(公告)日：2024-03-28
申请号：US17583956
申请日：2022-01-25
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventor： Theresa Hwang , Amy E. Keating , Meucci Ilunga , Sara Parker , Ghassan Mouneimne , Samantha Hill
CPC classification number: C07K7/08 , A61P35/00 , C07K14/001 , C07K2319/01
Abstract: Peptides that selectively bind ENAH (MENA) are described. The peptides are useful for treating certain cancers, such as triple negative breast cancer and for reducing resistance to taxane therapy.
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Patent Agency Ranking
公开(公告)号：US20240043476A1
公开(公告)日：2024-02-08
申请号：US17761255
申请日：2021-08-18
Inventor： Tadashi Matsuda , Kenji Oritani , Yuichi Kitai
CPC classification number: C07K14/001 , A61P35/00
Abstract: The present invention provides a peptide that consists of an amino acid sequence with 20 or fewer residues containing at least one amino acid sequence selected from the group consisting of the amino acid sequence represented in SEQ ID NO: 1, the amino acid sequence represented in SEQ ID NO: 2 and the amino acid sequence represented in SEQ ID NO: 38, the peptide having an activity to inhibit proliferation of a tumor cell or having an activity to inhibit binding between an epidermal growth factor receptor and a signal-transducing adaptor family member-2 (STAP-2); a peptide with a cell-penetrating peptide added to a terminus of the above peptide with or without a linker sequence interposed between the cell-penetrating peptide and the terminus; and pharmaceutical compositions containing any of these peptides.
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公开(公告)号：US20240034753A1
公开(公告)日：2024-02-01
申请号：US17788208
申请日：2021-01-29
Applicant: COHBAR, INC.
Inventor： Kenneth Cundy
CPC classification number: C07K14/001 , A61P1/16 , A61P3/04 , A61P35/00 , C07K11/00
Abstract: The disclosures herein relate to the fields of cell biology and the modulation of cellular mechanisms controlling cell viability, cell proliferation, and metabolic processes. More specifically disclosed herein are peptides effective to modulate cellular mechanisms controlling cell viability, cell proliferation, and metabolic processes, including cell signaling associated with aberrant cellular proliferation and malignancy. Also disclosed herein are peptides effective in modulating cellular mechanisms controlling cell viability, treating metabolic diseases, and as cytoprotective agents.
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公开(公告)号：US20240018187A1
公开(公告)日：2024-01-18
申请号：US18451003
申请日：2023-08-16
Applicant: THERADAPTIVE, INC.
Inventor： Luis ALVAREZ
CPC classification number: C07K7/08 , C07K14/001 , A61P19/00 , C07K14/51 , C07K14/475 , A61K38/1875 , A61K38/04 , A61K38/16
Abstract: Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof.
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公开(公告)号：US20240011010A1
公开(公告)日：2024-01-11
申请号：US18347423
申请日：2023-07-05
Applicant: California Institute of Technology
Inventor： Zibo Chen , Michael B. Elowitz
CPC classification number: C12N9/506 , C12Y304/22044 , C12N9/003 , C12Y105/01003 , C07K14/001
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in winner-take-all neural network computation in mammalian cells. In some embodiments, de novo designed protein heterodimers and engineered viral proteases are combined to implement a synthetic protein circuit that performs winner-take-all neural network computation. The synthetic protein circuit can include modules that compute weighted sums of input protein concentrations through reversible binding interactions, and allow for self-activation and mutual inhibition of protein components using irreversible proteolytic cleavage reactions.
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公开(公告)号：US20230416307A1
公开(公告)日：2023-12-28
申请号：US18339962
申请日：2023-06-22
Applicant: Synvivia, Inc.
Inventor： Gabriel Lopez , Charlie Huang
CPC classification number: C07K7/64 , C12N15/86 , C07K14/001 , C12N2740/15043 , C12N2740/15052 , C12N2750/14143 , C12N2750/14152
Abstract: The present disclosure provides methods and compositions for production of recombinant viral vectors, such as adeno-associated virus (AAV) vectors or lentiviral vectors, in host cells using engineered cyclic peptides that increase viral titer and transduction efficiency of viral vector compositions. The present disclosure also provides methods for selecting genetically encoded, endogenously expressed cyclic peptides that enhance viral vector manufacturability.
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