公开(公告)号：US11584770B2

公开(公告)日：2023-02-21

申请号：US16886985

申请日：2020-05-29

申请人： The Queen's University of Belfast

发明人： Marie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Mark Doherty

IPC分类号： C07H19/048 ,  C07H1/00 ,  C07H1/06 ,  C07H19/04

摘要： Methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I) wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido;
R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and
X− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

公开(公告)号：US11242364B1

公开(公告)日：2022-02-08

申请号：US17323789

申请日：2021-05-18

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.

公开(公告)号：US10815262B2

公开(公告)日：2020-10-27

申请号：US15905922

申请日：2018-02-27

申请人： The Queen's University of Belfast

发明人： Marie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Mark Doherty

IPC分类号： C07H19/00 ,  C07H19/048 ,  C07H1/00 ,  C07H1/06 ,  C07H19/04

摘要： The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I), wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and X− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

公开(公告)号：US20180258127A1

公开(公告)日：2018-09-13

申请号：US15977851

申请日：2018-05-11

申请人： ChromaDex Inc. ,  The Queen's University of Belfast

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Ryan Dellinger ,  Troy Rhonemus ,  Sylesh Venkataraman ,  Brian Nettles

IPC分类号： C07H19/048 ,  C07H1/00 ,  C07H19/04

CPC分类号： C07H19/048 ,  C07H1/00 ,  C07H19/04

摘要： The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.

公开(公告)号：US20160272668A1

公开(公告)日：2016-09-22

申请号：US15072121

申请日：2016-03-16

申请人： ChromaDex Inc. ,  The Queen's University of Belfast

发明人： Ryan Dellinger ,  Marie Eugenie Migaud ,  Philip Redpath ,  Troy Rhonemus ,  Richard Cunningham

IPC分类号： C07H19/048 ,  A61Q19/08 ,  A61Q19/00 ,  A61K8/60

CPC分类号： C07H19/048 ,  A61K8/675 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/007 ,  A61Q19/08

摘要： Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2′,3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2′,3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.

摘要翻译： 烟碱苷（NAR）衍生物，烟酰胺核苷（NR）和还原的NAR和NR，包括1-（2'，3'，5'-三乙酰基-β-D-呋喃核糖基）-1,4-二氢烟酸 提供含有相同和/或还原的衍生物形式的包括1-（2'，3'，5'-三乙酰基-β-D-呋喃核糖基）-1,4-烟酰胺（2）的烟酰胺核苷的组合物 用于护理皮肤和皮肤状况的治疗。 在一些实施方案中，本发明涉及含有一种或多种NR，NAR，NRH或NARH衍生物或其前药或盐的药物组合物和化妆品组合物。 在进一步的实施方案中，本发明涉及使用一种或多种NR，NAR，NRH或NARH衍生物或其前药，溶剂合物或其盐来促进细胞中烟酰胺腺嘌呤二核苷酸（NAD +）的细胞内水平的增加的方法，以及 用于改善细胞和组织存活的组织以及整个细胞和组织的健康。