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公开(公告)号：US20210283212A1
公开(公告)日：2021-09-16
申请号：US17143232
申请日：2021-01-07
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20210000927A1
公开(公告)日：2021-01-07
申请号：US16769732
申请日：2018-12-04
摘要： The present disclosure provides methods of treating paroxysmal nocturnal hemoglobinuria (PNH) in subjects with varying exposure to eculizumab by administering R5000. The methods include methods of switching subjects from treatment with eculizumab to R5000.
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公开(公告)号：US20200038477A1
公开(公告)日：2020-02-06
申请号：US16466165
申请日：2017-12-07
发明人： Alonso Ricardo , Steven James DeMarco , Sylvia Tobe , Michelle Denise Hoarty , Robert Paul Hammer , Douglas A. Treco , Kathleen Seyb , Vaishnavi Rajagopal , Guo-Qing Tang , Douangsone D. Vadysirisack , Ramin Farzaneh-Far
IPC分类号： A61K38/12 , A61K9/00 , A61K39/395 , A61P7/06
摘要： The present disclosure relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics. Also provided are methods of measuring C5 and related complexes using C5 binding agents.
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公开(公告)号：US20180371019A1
公开(公告)日：2018-12-27
申请号：US16128561
申请日：2018-09-12
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20220233632A1
公开(公告)日：2022-07-28
申请号：US17400267
申请日：2021-08-12
发明人： Alonso Ricardo , Steven James DeMarco , Sylvia Tobe , Michelle Denise Hoarty , Robert Paul Hammer , Douglas A. Treco , Kathleen Seyb , Vaishnavi Rajagopal , Guo-Qing Tang , Douangsone D. Vadysirisack , Ramin Farzaneh-Far
IPC分类号： A61K38/12 , A61P7/06 , A61K9/00 , A61K39/395
摘要： The present disclosure relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics. Also provided are methods of measuring C5 and related complexes using C5 binding agents.
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公开(公告)号：US11123399B2
公开(公告)日：2021-09-21
申请号：US16466165
申请日：2017-12-07
发明人： Alonso Ricardo , Steven James DeMarco , Sylvia Tobe , Michelle Denise Hoarty , Robert Paul Hammer , Douglas A. Treco , Kathleen Seyb , Vaishnavi Rajagopal , Guo-Qing Tang , Douangsone D. Vadysirisack , Ramin Farzaneh-Far
IPC分类号： A61K38/12 , A61P7/06 , A61K9/00 , A61K39/395
摘要： The present disclosure relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics. Also provided are methods of measuring C5 and related complexes using C5 binding agents.
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公开(公告)号：US10328115B2
公开(公告)日：2019-06-25
申请号：US15905158
申请日：2018-02-26
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20190119328A1
公开(公告)日：2019-04-25
申请号：US16237893
申请日：2019-01-02
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US10106579B2
公开(公告)日：2018-10-23
申请号：US15318063
申请日：2015-06-12
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20180256672A1
公开(公告)日：2018-09-13
申请号：US15978271
申请日：2018-05-14
发明人： Zhaolin Wang , Ping Ye , Alonso Ricardo , Kristopher Josephson , Paul Anderson , Michelle Denise Hoarty , Zhong Ma , Nathan Ezekiel Nims , Eberhard Schneider , Gregor Schurmann , Peter Wagner , Douglas A. Treco , Hong Zheng , Daniel Elbaum , Nicolas Cedric Boyer
CPC分类号： A61K38/10 , A61K9/0048 , A61K9/0051 , A61K38/00 , A61K45/06 , A61K47/60 , C07K7/08 , C08G65/48
摘要： The present invention provides inhibitors and/or antagonists of plasma kallikrein. Also provided are methods of utilizing the inhibitors as therapeutics.
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