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公开(公告)号：US5690815A
公开(公告)日：1997-11-25
申请号：US367296
申请日：1995-04-06
CPC分类号： B01D61/22 , A61M1/02 , A61M1/0227 , A61M1/025 , A61M1/029 , B01D61/20 , B01D65/08 , A61M2202/0413 , A61M2202/0429 , A61M2202/0439 , A61M5/1486 , B01D2321/04 , B01D2321/2066
摘要： An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly including a first container operatively associated with the pressure differential generator, at least one satellite container in fluid communication with the first container and a porous medium including a leukocyte depletion medium interposed between the first container and the satellite container and a sensor downstream of the porous medium for sensing and providing a signal reflecting the presence of red blood cells downstream of the porous medium. An automated control arrangement is coupled to the sensor to receive the signal from the sensor and coupled to at least one of the pressure differential generator and the biological fluid processing assembly to control flow between the first container and the satellite container.
摘要翻译： PCT No.PCT / US93 / 06547。 371日期：1995年4月6日 102（e）日期1995年4月6日PCT提交1993年7月13日PCT公布。 出版物WO94 / 01193 1994年1月20日，用于处理生物流体的自动化系统包括压差发生器，生物流体处理组件，其包括与压差发生器可操作地相关联的第一容器，与第一容器流体连通的至少一个卫星容器和多孔 介质，其包括插入在第一容器和卫星容器之间的白细胞消耗介质和在多孔介质下游的传感器，用于感测并提供反映多孔介质下游红细胞存在的信号。 自动控制装置耦合到传感器以接收来自传感器的信号并且耦合到压力差发生器和生物流体处理组件中的至少一个，以控制第一容器和卫星容器之间的流动。
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公开(公告)号：US5601727A
公开(公告)日：1997-02-11
申请号：US232174
申请日：1994-08-02
CPC分类号： B01D61/147 , A61M1/34 , A61M1/3603 , B01D63/08 , A61M2202/0415 , A61M2202/0439 , A61M5/1452 , A61M5/1486
摘要： A device and method for processing a biological fluid comprises directing the biological fluid tangentially or parallel to the face of a separation medium in at least one serpentine fluid flow channel such that a plasma-rich fluid passes through the separation medium and a plasma-depleted fluid passes tangentially to the surface of the separation medium.
摘要翻译： PCT No.PCT / US92 / 09542 Sec。 371日期1994年8月2日 102（e）日期1994年8月2日PCT提交1992年11月3日PCT公布。 出版物WO93 / 08904 日期1993年5月13日用于处理生物流体的装置和方法包括在至少一个蛇形流体流动通道中将生物流体切向或平行于分离介质的表面引导，使得富含血浆的流体通过分离介质和 等离子体耗尽的液体切向地传递到分离介质的表面。
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公开(公告)号：US5543060A
公开(公告)日：1996-08-06
申请号：US467322
申请日：1995-06-06
CPC分类号： B01D39/1623 , A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439
摘要： A device for processing donated blood comprises a porous medium interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 70 to about 115 dynes/cm. The porous medium blocks red blood cells, but allows platelets to pass therethrough.
摘要翻译： 用于处理捐赠血液的装置包括介于收集袋和卫星袋之间的多孔介质，其中通过离心分离的组分可以表达在其中，所述过滤元件优选具有约70至约115达因/厘米3的CWST。 多孔介质阻止红细胞，但允许血小板通过。
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公开(公告)号：US5360545A
公开(公告)日：1994-11-01
申请号：US100919
申请日：1993-08-03
申请人： David B. Pall , Thomas C. Gsell
发明人： David B. Pall , Thomas C. Gsell
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/36 , B01D39/16 , B01D61/14 , B01D61/16 , B01D63/08 , B01D39/00
CPC分类号： B01D63/087 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/029 , A61M1/3633 , A61M1/3646 , A61M1/3652 , B01D39/1623 , B01D61/147 , B01D61/16 , A61J1/10 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12
摘要： The invention provides processing donated blood, particularly a platelet-containing solution such as platelet-containing plasma, involving separating blood into a red cell containing sediment layer and a supernatant layer, and passing the supernatant layer through a filter until the filter is blocked, thereby leaving platelets to be harvested. The preferred filter comprises a porous medium having a plurality of zones of progressively increasing density.
摘要翻译： 本发明提供了处理捐献血液，特别是含血小板的溶液如含血小板的血浆，包括将血液分离成含有沉积物层和上清液层的红细胞，并将上清液层通过过滤器直至过滤器被阻断， 使血小板收获。 优选的过滤器包括具有逐渐增加的密度的多个区域的多孔介质。
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公开(公告)号：US5266219A
公开(公告)日：1993-11-30
申请号：US745166
申请日：1991-08-15
CPC分类号： B01D39/163 , G01N33/491 , Y10T436/25375
摘要： A device for separating plasma from blood is provided comprising a synthetic polymeric fibrous structure having a CWST in excess of 65 dynes/cm, the structure having a first region for receiving a blood sample and a second region for accumulating plasma.
摘要翻译： 提供了一种用于从血液中分离血浆的装置，其包括具有超过65达因/厘米的CWST的合成聚合物纤维结构，所述结构具有用于接收血液样品的第一区域和用于积聚血浆的第二区域。
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公开(公告)号：US5252222A
公开(公告)日：1993-10-12
申请号：US620775
申请日：1990-12-03
IPC分类号： A61K9/00 , A61M5/165 , B01D19/00 , B01D36/00 , B01D39/16 , B01D61/14 , B01D61/18 , B01D63/08 , B01D69/12 , B01D61/00 , B01D39/00
CPC分类号： A61K9/0029 , A61M5/165 , B01D19/0031 , B01D36/001 , B01D39/1623 , B01D61/147 , B01D61/18 , B01D63/087 , B01D69/12 , A61M2005/1657
摘要： A filter device and method are provided for treating parenteral nutrient fluids, particularly TNA systems containing lipids, glucose, and amino acids. The filter device comprises a housing and a microporous medium in the form of a synthetic polymeric microporous structure having a pore rating of less than 1.2 micrometers. A preferred microporous medium comprises, in series, a matrix of microfibers which has been radiation grafted to render the matrix wettable by parenteral nutrient fluids followed by a microporous membrane, also wettable by parenteral nutrient fluids, and having a finer pore rating than the microfibrous matrix.
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公开(公告)号：US06322709B1
公开(公告)日：2001-11-27
申请号：US09558270
申请日：2000-04-25
IPC分类号： B01D3700
CPC分类号： B01D61/22 , A61M1/02 , A61M1/0227 , A61M1/025 , A61M1/029 , A61M5/1486 , A61M2202/0413 , A61M2202/0429 , A61M2202/0439 , B01D61/20 , B01D65/08 , B01D2321/04 , B01D2321/2066 , A61M2202/0092 , A61M2202/005
摘要： A method for automatically processing a biological fluid is disclosed. The method includes the steps of obtaining a container having a biological fluid therein, providing a first signal and communicating with an automated control arrangement to establish flow of at least a portion of the biological fluid along a fluid flow path through a leukocyte depletion medium, providing a second signal and communicating with the automatic control arrangement to terminate flow along the fluid flow path wherein providing the second signal includes sensing the back pressure in the fluid flow path or the flow rate through the leukocyte depletion medium.
摘要翻译： 公开了一种用于自动处理生物流体的方法。 该方法包括以下步骤：在其中获得具有生物流体的容器，提供第一信号并与自动控制装置连通，以建立至少一部分生物流体沿着通过白细胞消耗介质的流体流动路径的流动，从而提供 第二信号并与自动控制装置通信以终止沿着流体流动路径的流动，其中提供第二信号包括感测流体流动路径中的背压或通过白细胞消耗介质的流速。
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公开(公告)号：US06106727A
公开(公告)日：2000-08-22
申请号：US949817
申请日：1997-10-14
IPC分类号： A61M1/02 , A61M5/148 , B01D21/30 , B01D61/20 , B01D61/22 , B01D65/08 , B01D36/00 , B01D37/00
CPC分类号： B01D61/22 , A61M1/02 , A61M1/0227 , A61M1/025 , A61M1/029 , B01D61/20 , B01D65/08 , A61M2202/0413 , A61M2202/0429 , A61M2202/0439 , A61M5/1486 , B01D2321/04 , B01D2321/2066
摘要： An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly, and an automated control arrangement coupled to at least one of the pressure differential generator and the biological fluid processing assembly. The automated system may include a porous medium, such as a red cell barrier medium, a leukocyte depletion medium, or a combination red cell barrier/leukocyte depletion medium. The automated system may also include a sensor producing a signal reflecting a parameter of fluid flow.
摘要翻译： 用于处理生物流体的自动化系统包括压差发生器，生物流体处理组件和耦合到压力差发生器和生物流体处理组件中的至少一个的自动控制装置。 自动化系统可以包括多孔介质，例如红细胞屏障介质，白细胞消耗介质，或组合的红细胞屏障/白细胞消耗介质。 自动化系统还可以包括产生反映流体流动参数的信号的传感器。
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公开(公告)号：US5744047A
公开(公告)日：1998-04-28
申请号：US294051
申请日：1994-08-24
CPC分类号： B01D39/1623 , A61M1/3633 , A61M2202/0439 , A61M2205/7536 , A61M2206/16
摘要： Leucocyte depletion filter assemblies decrease the leucocyte content of a leucocyte-containing liquid at a flow rate of greater than about 25 milliliters per minute. These filter assemblies are suitable for use in an extracorporeal circuit. Methods for removing leucocytes and other deleterious matter are also disclosed.
摘要翻译： 白细胞消耗过滤器组件以大于约25毫升/分钟的流速降低含白细胞液体的白细胞含量。 这些过滤器组件适用于体外循环。 还公开了除去白细胞和其它有害物质的方法。
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公开(公告)号：US5616254A
公开(公告)日：1997-04-01
申请号：US451494
申请日：1995-05-26
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/34 , A61M1/36 , A61M5/148 , B01D61/14 , B01D61/16 , B01D61/20 , B01D61/22 , B01D63/08 , B01D65/08 , B01D37/00 , A61M1/00 , B01D21/26 , B01D39/00
CPC分类号： B01D63/087 , A61J1/05 , A61M1/02 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/025 , A61M1/029 , A61M1/3472 , A61M1/3633 , A61M1/3646 , A61M1/3652 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D61/22 , B01D65/08 , A61J1/10 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , A61M5/1486 , B01D2321/2083
摘要： A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
摘要翻译： 用于收集和处理捐赠血液的系统包括介于血液收集袋和卫星袋之间的第一多孔介质和介于血液收集袋和另一卫星袋之间的第二多孔介质。 多孔介质是白细胞消耗介质。 该系统还可以包括以下一种或多种：红细胞阻挡介质，分离介质，气体入口和气体出口。 该系统可用于将全血离心成一个或多个组分，并且包括在离心过程中保护系统的方法。
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