公开(公告)号：US09062071B2

公开(公告)日：2015-06-23

申请号：US14366466

申请日：2012-12-17

Applicant: Merck Sharp & Dohme Corp

Inventor： Yao Ma ,  Manami Shizuka ,  Timothy J. Guzi ,  Yuan Liu ,  Yuan Tian ,  Brian R. Lahue ,  Craig R. Gibeau ,  Gerald W. Shipps, Jr. ,  Yaolin Wang ,  Stephane L. Bogen ,  Latha G. Nair ,  Weidong Pan ,  Mark A. McCoy ,  Matthew E. Voss ,  Margarita Kirova-Snover ,  W. Bent Clayton

IPC: C07D409/14 ,  C07D495/04 ,  A61K31/497

CPC classification number: C07D495/04 ,  C07D409/14

Abstract: The present invention provides a compound of Formula I (The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

Abstract translation: 本发明提供如本文所述的式I化合物（该式应该在此插入）或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。

公开(公告)号：US08962611B2

公开(公告)日：2015-02-24

申请号：US14465577

申请日：2014-08-21

Applicant: Merck Sharp & Dohme Corp.

Inventor： Matthew P. Christopher ,  Francesc Xavier Fradera Llinas ,  Michelle Machacek ,  Michelle Martinez ,  Michael Hale Reutershan ,  Manami Shizuka ,  Binyuan Sun ,  Christopher Francis Thompson ,  B. Wesley Trotter ,  Matthew E. Voss ,  Michael D. Altman ,  Stephane L. Bogen ,  Ronald J. Doll

IPC: A61K31/553 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D471/08 ,  C07D498/04 ,  C07D519/00

Abstract: The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

Abstract translation: 本发明提供如本文所述的取代的咪唑并吡啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。

公开(公告)号：US08846657B2

公开(公告)日：2014-09-30

申请号：US14132946

申请日：2013-12-18

Applicant: Merck Sharp & Dohme Corp.

Inventor： Matthew P. Christopher ,  Francesc Xavier Fradera Llinas ,  Michelle Machacek ,  Michelle Martinez ,  Michael Hale Reutershan ,  Manami Shizuka ,  Binyuan Sun ,  Christopher Francis Thompson ,  B. Wesley Trotter ,  Matthew E. Voss ,  Michael D. Altman ,  Stephane L. Bogen ,  Ronald J. Doll

IPC: A61K31/553 ,  C07D471/04 ,  C07D471/08 ,  C07D498/04

CPC classification number: C07D471/04 ,  C07D471/08 ,  C07D498/04 ,  C07D519/00

Abstract: The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

Abstract translation: 本发明提供如本文所述的取代的咪唑并吡啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。