Invention Grant
- Patent Title: Substituted piperidines as HDM2 inhibitors
- Patent Title (中): 取代的哌啶作为HDM2抑制剂
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Application No.: US14366466Application Date: 2012-12-17
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Publication No.: US09062071B2Publication Date: 2015-06-23
- Inventor: Yao Ma , Manami Shizuka , Timothy J. Guzi , Yuan Liu , Yuan Tian , Brian R. Lahue , Craig R. Gibeau , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Latha G. Nair , Weidong Pan , Mark A. McCoy , Matthew E. Voss , Margarita Kirova-Snover , W. Bent Clayton
- Applicant: Merck Sharp & Dohme Corp
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Yong Zhao; Laura M. Ginkel
- International Application: PCT/US2012/069996 WO 20121217
- International Announcement: WO2013/096150 WO 20130627
- Main IPC: C07D409/14
- IPC: C07D409/14 ; C07D495/04 ; A61K31/497
Abstract:
The present invention provides a compound of Formula I (The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
Public/Granted literature
- US20140323482A1 SUBSTITUTED PIPERIDINES AS HDM2 INHIBITORS Public/Granted day:2014-10-30
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