公开(公告)号：US20120270837A1

公开(公告)日：2012-10-25

申请号：US13459898

申请日：2012-04-30

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A61K31/122 ,  A61K31/7008 ,  A61P29/00 ,  C12N5/071

CPC分类号： A61K31/12 ,  A61K31/203 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US08257754B2

公开(公告)日：2012-09-04

申请号：US13430154

申请日：2012-03-26

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence M. Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence M. Howell

IPC分类号： A01N65/00

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US20120183634A1

公开(公告)日：2012-07-19

申请号：US13430154

申请日：2012-03-26

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A61K36/53 ,  A61P29/00

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US07820206B2

公开(公告)日：2010-10-26

申请号：US11344554

申请日：2006-01-30

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K36/185 ,  A61K31/12

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.

公开(公告)号：US07722903B2

公开(公告)日：2010-05-25

申请号：US11344559

申请日：2006-01-30

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K36/185 ,  A61K31/12

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。

公开(公告)号：US07431948B2

公开(公告)日：2008-10-07

申请号：US11403016

申请日：2006-04-12

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K45/06 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US07270835B2

公开(公告)日：2007-09-18

申请号：US10689856

申请日：2003-10-20

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K45/06 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US20120177756A1

公开(公告)日：2012-07-12

申请号：US13430073

申请日：2012-03-26

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A61K36/53 ,  A61P29/00

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US08206753B2

公开(公告)日：2012-06-26

申请号：US11635305

申请日：2006-12-07

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Amy J. Hall ,  Veera Konda ,  Linda M. Pacioretty

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Amy J. Hall ,  Veera Konda ,  Linda M. Pacioretty

IPC分类号： A01N65/00

CPC分类号： A61K36/48 ,  A61K36/185 ,  A61K36/23 ,  A61K36/282 ,  A61K36/31 ,  A61K36/73 ,  A61K36/80 ,  A61K2300/00

摘要： Disclosed are botanically based compositions and methods useful for the treatment of metabolic syndrome and diabetes type 2. Compositions, kits, and methods are additionally disclosed for means to augment the activity of identified glucose and insulin regulating drugs.

摘要翻译： 公开了用于治疗代谢综合征和类型2的糖尿病的基于植物学的组合物和方法。另外公开了组合物，试剂盒和方法，以增加鉴定的葡萄糖和胰岛素调节药物的活性。

公开(公告)号：US08142819B2

公开(公告)日：2012-03-27

申请号：US10464410

申请日：2003-06-18

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。