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公开(公告)号：US09708597B2
公开(公告)日：2017-07-18
申请号：US14158106
申请日：2014-01-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
CPC classification number: C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US09585974B2
公开(公告)日：2017-03-07
申请号：US15187115
申请日：2016-06-20
Applicant: General Electric Company
Inventor： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Andrew Soliz Torres
CPC classification number: A61K49/101 , A61K49/0002 , A61K49/04 , A61K49/0428 , A61K49/0485 , A61K49/1818 , A61K49/1848 , B82Y5/00 , B82Y30/00 , C01G35/00 , Y10S977/773 , Y10S977/779 , Y10S977/927 , Y10S977/928 , Y10T428/2982
Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.
Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。
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公开(公告)号：US09452199B2
公开(公告)日：2016-09-27
申请号：US14157819
申请日：2014-01-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
CPC classification number: A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
Abstract translation: 公开了用于释放生长因子的方法和系统。 在某些实施方案中，将血液样品暴露于一个或多个电脉冲的序列以触发样品中生长因子的释放。 在某些实施方案中，生长因子释放不伴随血液样品内的凝血。
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公开(公告)号：US09238808B2
公开(公告)日：2016-01-19
申请号：US13911987
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: C12N13/00 , H02J7/0052 , H02J2007/0059 , H03K3/57 , Y10T307/707
Abstract: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.
Abstract translation: 用于在负载上施加电脉冲的脉冲发生系统包括串联连接在正极链上并被配置为向负载施加正电位的第一多个能量存储模块和串联连接在负极上的第二多个能量存储模块 并配置为向负载施加负电位。 正链和负链的每个储能模块包括整流器和存储元件，以及至少一个控制元件。
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公开(公告)号：US20140363881A1
公开(公告)日：2014-12-11
申请号：US13911987
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: C12N13/00 , H02J7/0052 , H02J2007/0059 , H03K3/57 , Y10T307/707
Abstract: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.
Abstract translation: 用于在负载上施加电脉冲的脉冲发生系统包括串联连接在正极链上并被配置为向负载施加正电势的第一多个能量存储模块和串联连接在负极上的第二多个能量存储模块 并配置为向负载施加负电位。 正链和负链的每个储能模块包括整流器和存储元件，以及至少一个控制元件。
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Patent Agency Ranking
公开(公告)号：US11525768B2
公开(公告)日：2022-12-13
申请号：US16538616
申请日：2019-08-12
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US11464829B2
公开(公告)日：2022-10-11
申请号：US16514662
申请日：2019-07-17
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US10927345B2
公开(公告)日：2021-02-23
申请号：US15694635
申请日：2017-09-01
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
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公开(公告)号：US20170362571A1
公开(公告)日：2017-12-21
申请号：US15694635
申请日：2017-09-01
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
CPC classification number: C12N5/0644 , C12M35/02 , C12N2529/00
Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
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公开(公告)号：US20170191052A1
公开(公告)日：2017-07-06
申请号：US14984988
申请日：2015-12-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Steve Lambert Klopman
CPC classification number: C12N13/00 , A61K33/06 , A61K35/19 , A61K38/18 , A61K41/00 , C12N5/0644 , A61K2300/00
Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
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