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    Epileptic event detection based on correlation of body signals
    23.
    发明授权
    Epileptic event detection based on correlation of body signals 有权

    公开(公告)号：US10993652B2

    公开(公告)日：2021-05-04

    申请号：US14208466

    申请日：2014-03-13

    Applicant: Flint Hills Scientific, L.L.C.

    Inventor： Ivan Osorio

    IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/11

    Abstract: We report a method of a method for detecting an epileptic seizure, comprising providing a first body signal reference value; determining a current body signal value from a time series of body signals; comparing the current body signal value and the first reference value; determining a work level of the patient; determining whether the current body signal value comprises an ictal component, based on the work level and the comparing; issuing a detection of an epileptic seizure in response to the determination that the current body signal value comprises the ictal component; and taking at least one further action (e.g. warning, delivering a therapy, etc.), based on the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

    Epileptic seizure prevention or treatment via heart rate clamping
    24.
    发明授权
    Epileptic seizure prevention or treatment via heart rate clamping 有权

    公开(公告)号：US10363362B2

    公开(公告)日：2019-07-30

    申请号：US14201609

    申请日：2014-03-07

    Applicant: Flint Hills Scientific, L.L.C.

    Inventor： Ivan Osorio

    IPC: A61M5/172 ,  A61N1/36 ,  A61B17/132 ,  A61F7/00 ,  A61F7/12 ,  A61F7/10 ,  A61F7/02

    Abstract: We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

    EPILEPTIC SEIZURE THERAPIES COMPRISING PARTIAL REDUCTION OR COOLING OF BLOOD FLOW TO BRAIN REGIONS
    28.
    发明申请
    EPILEPTIC SEIZURE THERAPIES COMPRISING PARTIAL REDUCTION OR COOLING OF BLOOD FLOW TO BRAIN REGIONS 审中-公开
    包括部分减少或冷却血液流向脑区的特殊治疗

    公开(公告)号：US20140276551A1

    公开(公告)日：2014-09-18

    申请号：US14170246

    申请日：2014-01-31

    Applicant: Flint Hills Scientific, L.L.C.

    Inventor： Ivan Osorio

    IPC: A61M5/172 ,  A61F7/00 ,  A61B17/132

    CPC classification number: A61M5/1723 ,  A61B17/1325 ,  A61F7/007 ,  A61F7/10 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0075 ,  A61F2007/0282 ,  A61F2007/126 ,  A61N1/36053 ,  A61N1/36064

    Abstract: We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by at least one of: applying a pressure, applying a cooling, or administering a vasoconstrictive agent to a vessel supplying blood to at least a portion of the brain. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

    Abstract translation: 我们报告一种治疗患者癫痫发作的方法，其包括：基于来自所述患者的身体数据检测所述癫痫发作; 以及响应于所述检测到的癫痫发作，减少所述患者的脑部血液流动; 其中所述还原通过以下至少一种来实现：施加压力，施加冷却或施用血管收缩剂到向至​​少一部分脑供血的血管。 我们还报告配置为实施该方法的医疗设备系统。 我们还报告了一种非暂时性的计算机可读程序存储单元，其中编码有指令，当由计算机执行时，执行该方法。

    AUTOMATED MEANS TO CONTROL RESPONSES TO REPETITIVE ELECTRICAL STIMULATION AND IMPROVE THERAPEUTIC EFFICACY
    29.
    发明申请
    AUTOMATED MEANS TO CONTROL RESPONSES TO REPETITIVE ELECTRICAL STIMULATION AND IMPROVE THERAPEUTIC EFFICACY 审中-公开
    自动化控制反应电刺激和提高治疗效果的手段

    公开(公告)号：US20140276194A1

    公开(公告)日：2014-09-18

    申请号：US14201482

    申请日：2014-03-07

    Applicant: Flint Hills Scientific, L.L.C.

    Inventor： Ivan Osorio

    IPC: A61B5/00 ,  A61N1/36

    CPC classification number: A61B5/4094 ,  A61B5/0484 ,  A61N1/36064 ,  A61N1/36139

    Abstract: We report a method for optimizing the therapeutic efficacy of evoked responses elicited by one or more electrical impulses delivered to a neural structure, comprising: comparing a test evoked response to an evoked response elicited by therapeutically efficacious electrical stimulation; adjusting at least one parameter of the electrical impulses in response to a determination that said test evoked response is not similar to the therapeutic evoked response; determining that the test evoked response resembles the therapeutic evoked response after performing at least one of said adjustments; and saving to memory at least one adjusted parameter that increased the similarity between the test evoked response and the therapeutic evoked response. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

    Abstract translation: 我们报告一种用于优化由递送到神经结构的一个或多个电脉冲引起的诱发反应的治疗功效的方法，包括：将测试诱发反应与由治疗有效的电刺激引起的诱发反应进行比较; 响应于所述测试诱发反应与治疗诱发反应不相似的确定，调整电脉冲的至少一个参数; 在执行所述调整中的至少一个之后，确定所述测试诱发反应类似于所述治疗诱发反应; 并且将记忆保存至少一个调整的参数，这增加了测试诱发反应与治疗诱发反应之间的相似性。 我们还报告配置为实施该方法的医疗设备系统。 我们还报告了一种非暂时性的计算机可读程序存储单元，其中编码有指令，当由计算机执行时，执行该方法。

    SEIZURE DETECTION BASED ON WORK LEVEL EXCURSION
    30.
    发明申请
    SEIZURE DETECTION BASED ON WORK LEVEL EXCURSION 有权
    基于工作水平检测的检测

    公开(公告)号：US20140275831A1

    公开(公告)日：2014-09-18

    申请号：US14169006

    申请日：2014-01-30

    Applicant: FLINT HILLS SCIENTIFIC, L.L.C.

    Inventor： Ivan Osorio

    IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/0205

    CPC classification number: A61B5/4094 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/14551 ,  A61B5/4848 ,  A61B5/4866 ,  G06F19/00

    Abstract: We report a method of determining an occurrence of an epileptic convulsive seizure in a patient, comprising: receiving body data from a patient during a first time period, determining a work level relating to said first time period at least based partially upon said body data; determining whether said work level exceeds an extreme work level threshold; performing a responsive action, in response to a determination that said work level exceeds said extreme work level threshold. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

    Abstract translation: 我们报告一种确定患者癫痫性惊厥发作的方法，包括：在第一时间段期间从患者接收身体数据，至少基于所述身体数据确定与所述第一时间段有关的工作等级; 确定所述工作级别是否超过极限工作级别阈值; 响应于所述工作级别超过所述极限工作级别阈值的确定，执行响应动作。 我们还报告配置为实施该方法的医疗设备系统。 我们还报告了一种非暂时性的计算机可读程序存储单元，其中编码有指令，当由计算机执行时，执行该方法。

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