公开(公告)号：US11566076B2

公开(公告)日：2023-01-31

申请号：US16808910

申请日：2020-03-04

Applicant: Five Prime Therapeutics, Inc. ,  Bristol-Myers Squibb Company

Inventor： Brian Wong ,  Julie Hambleton ,  Robert Sikorski ,  Emma Masteller ,  Kevin Hestir ,  David Bellovin ,  Katherine E. Lewis

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.

公开(公告)号：US11559583B2

公开(公告)日：2023-01-24

申请号：US16786158

申请日：2020-02-10

Applicant: Five Prime Therapeutics, Inc.

Inventor： Emma Masteller ,  Thomas Brennan ,  David Bellovin ,  Kevin P. Baker ,  Brian Wong

IPC: C07K16/28 ,  A61P35/00 ,  A61K51/10 ,  A61K39/00 ,  A61K47/68

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with one or more immune stimulating agents are provided.

公开(公告)号：US11421034B2

公开(公告)日：2022-08-23

申请号：US16646690

申请日：2018-09-12

Applicant: Five Prime Therapeutics, Inc. ,  Bristol-Myers Squibb Company

Inventor： Katherine E. Lewis ,  Serena Kimi Perna ,  Michael Carleton ,  Ke Xu ,  Penny Phillips ,  Dimple Pandya ,  Brian Wong ,  Julie Hambleton ,  Robert Sikorski ,  Emma Masteller ,  Kevin Hestir ,  David Bellovin ,  Janine Powers ,  Ernestine Lee

IPC: C07K16/28 ,  A61K47/69 ,  A61K47/64 ,  A61P35/00 ,  A61K31/337 ,  A61K31/513 ,  A61K31/7068 ,  A61K39/395 ,  C12Q1/6886 ,  A61K39/00

Abstract: The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).

公开(公告)号：US20200299392A1

公开(公告)日：2020-09-24

申请号：US16808910

申请日：2020-03-04

Applicant: Five Prime Therapeutics, Inc. ,  Bristol-Myers Squibb Company

Inventor： Brian Wong ,  Julie Hambleton ,  Robert Sikorski ,  Emma Masteller ,  Kevin Hestir ,  David Bellovin ,  Katherine E. Lewis

IPC: C07K16/28 ,  C07K16/30

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.

公开(公告)号：US10273281B2

公开(公告)日：2019-04-30

申请号：US15340238

申请日：2016-11-01

Applicant: Five Prime Therapeutics, Inc.

Inventor： Thomas Brennan ,  David Bellovin ,  David Busha ,  Barbara Sennino

IPC: C07K14/705 ,  A61K38/17 ,  A61K39/395 ,  A61K45/06 ,  C07K16/00 ,  C07K16/28 ,  A61K38/00

Abstract: This application relates to CD80 (B7-1) extracellular domain (ECD) polypeptides and CD80-ECD fusion molecules and their use in treatment of cancer, both alone and in combination with other therapeutic agents, such as immune stimulating agents such as PD-1/PD-L1 inhibitors.

公开(公告)号：US20180016555A1

公开(公告)日：2018-01-18

申请号：US15520998

申请日：2015-10-21

Applicant: Five Prime Therapeutics, Inc.

Inventor： Luis Borges ,  Nathan Sallee ,  Charles Kaplan ,  Arthur Brace ,  W. Michael Kavanaugh ,  Brian Wong ,  David Bellovin ,  Thomas Brennan ,  Artur Karasyov

IPC: C12N5/0783 ,  C07K16/28 ,  G01N33/50

CPC classification number: C12N5/0636 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2317/76 ,  C07K2319/30 ,  C12N2501/599 ,  G01N33/505

Abstract: Methods of identifying and using SLAMF1 antagonists are provided.