公开(公告)号：US09273058B2

公开(公告)日：2016-03-01

申请号：US14541343

申请日：2014-11-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Upender Velaparthi ,  Chetan Padmakar Darne ,  Peiying Liu ,  Mark D. Wittman ,  Bradley C. Pearce ,  Erika M. V. Araujo ,  Bireshwar Dasgupta ,  Jalathi Surendran Nair ,  Sakthi Kumaran Janakiraman ,  Chandrasekhar Reddy Rachamreddy ,  Mettu Mallikarjuna Rao ,  Arul Mozhi Selvan Subbiah Karuppiah ,  Bandreddy Subba Reddy ,  Pulicharla Nagalakshmi ,  Rajesh Onkardas Bora ,  Shilpa Holehatti Maheshwarappa ,  Selvakumar Kumaravel ,  Dibakar Mullick ,  Ramesh Sistla

IPC: C07D487/04 ,  C07D487/10 ,  C07D487/20 ,  C07D491/147 ,  C07D491/20 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61P19/02

CPC classification number: C07D487/04 ,  C07D487/10 ,  C07D487/20 ,  C07D491/147 ,  C07D491/20 ,  C07D519/00

Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）的化合物抑制蛋白激酶活性，从而使它们用作抗癌剂。