公开(公告)号：US20030130545A1

公开(公告)日：2003-07-10

申请号：US10214983

申请日：2002-08-06

发明人： Todd A. Werpy ,  John G. Frye JR. ,  Alan H. Zacher ,  Dennis J. Miller

IPC分类号： C07C031/18 ,  B01J023/00

CPC分类号： C07C29/00 ,  B01J21/18 ,  B01J23/36 ,  B01J23/8896 ,  C07C29/149 ,  C07C29/60 ,  Y02P20/52 ,  C07C31/205 ,  C07C31/225 ,  C07C31/202

摘要： Methods and compositions for reactions of hydrogen over a Re-containing catalyst with compositions containing a 5-carbon sugar, sugar alcohol, or lactic acid are described. It has been surprisingly discovered that reaction with hydrogen over a Re-containing multimetallic catalyst resulted in superior conversion and selectivity to desired products such as propylene glycol. A process for the synthesis of PG from lactate or lactic acid is also described.

摘要翻译： 描述了在含Re催化剂上的氢与含有5-碳糖，糖醇或乳酸的组合物的反应的方法和组合物。 已经令人惊讶地发现与含氢多金属催化剂上的氢反应导致对所需产物如丙二醇的优异的转化率和选择性。 还描述了从乳酸或乳酸合成PG的方法。

公开(公告)号：US20030100777A1

公开(公告)日：2003-05-29

申请号：US10149199

申请日：2002-06-10

发明人： Michael Anthony Wood ,  Paul Willett ,  Robert Wild ,  Stephen William Colley

IPC分类号： C07D301/02 ,  C07D305/00 ,  C07C031/18

CPC分类号： C07D315/00 ,  C07C29/177 ,  C07D307/08 ,  C07D307/20 ,  C07C31/207

摘要： A process for the co-production of a diol product (e.g. butane-1,4-diol) and a cyclic ether (e.g. tetrahydrofuran) by hydrogenation of an aliphatic diester or lactone feedstock (e.g. dimethyl or diethyl maleate), which contains a minor amount of acidic material, such as the corresponding monoester. The process utilizes a plurality of hydrogenation zones connected in series, each containing a charge of a granular ester hydrogenation catalyst. The catalyst in the first hydrogenation zone is tolerant of a minor amount of acidic material, while the catalyst in the second hydrogenation zone provides enhanced yields of cyclic ethers compared to the catalyst of the first hydrogenation zone. The catalyst in a third hydrogenation zone exhibits low selectivity towards conversion of the diester to at least one by product (e.g. 2-4null-hydroxybutoxy-tetrahydrofuran). The feedstock is supplied to the first hydrogenation zone as a vaporous stream comprising hydrogen and there is recovered a final product stream from the third hydrogenation zone which is substantially free of the hydrogenatable material and contains the diol, cyclic ether and other by products, the selectivity to the cyclic ether being greater in the final product stream than in the first intermediate product stream.

摘要翻译： 通过氢化脂族二酯或内酯原料（例如二甲基或二乙基马来酸酯）共同制备二醇产物（例如丁烷-1,4-二醇）和环醚（例如四氢呋喃）的方法，其包含未成熟的 酸性物质的量，如相应的单酯。 该方法利用串联连接的多个氢化区，每个加氢区含有粒状酯加氢催化剂。 第一加氢区中的催化剂耐受少量酸性物质，而与第一氢化区的催化剂相比，第二加氢区中的催化剂提供了更高的环醚产率。 在第三加氢区中的催化剂对于将二酯转化为至少一种副产物（例如2-4'-羟基丁氧基 - 四氢呋喃）表现出低的选择性。 原料作为包含氢气的气流被供应到第一氢化区，并且从第三氢化区回收最终产物流，其基本上不含可氢化材料并含有二醇，环醚和其它产物，选择性 在最终产物流中环醚比在第一中间产物流中更大。

公开(公告)号：US20030097028A1

公开(公告)日：2003-05-22

申请号：US10299138

申请日：2002-11-19

发明人： Patrick Fuertes

IPC分类号： C07C031/18 ,  C07C029/94

CPC分类号： C07D493/04 ,  C07B63/04 ,  C07D307/20

摘要： The subject of the present invention is a novel method for preparing a composition of internal dehydration product of a hydrogenated sugar, comprising: a) a step of distilling a medium containing the said internal dehydration product in order to obtain a distillate enriched with this product, b) optionally, at least one subsequent step of purifying the distillate thus obtained, c) a subsequent step of bringing the distillate obtained during step a), and then optionally subjected to step b), into contact with an agent capable of improving the stability of the internal dehydration product predominantly contained in the distillate, the said agent not being in gaseous form, d) optionally, a subsequent step of shaping the resulting composition of internal dehydration product of a hydrogenated sugar. This method makes it possible in particular to obtain a stable isosorbide composition, characterized by its purity and/or its content of certain stabilizing or nonstabilizing species.

摘要翻译： 本发明的主题是制备氢化糖的内部脱水产物的组合物的新方法，其包括：a）蒸馏含有所述内部脱水产物的培养基以获得富含该产物的馏出物的步骤， b）任选地，至少一个后续步骤，纯化由此获得的馏出物，c）随后的步骤，使步骤a）中获得的馏出物，然后任选地进行步骤b），与能够改善稳定性的试剂接触 主要包含在馏出物中的内部脱水产物，所述试剂不是气态形式，d）任选地，随后的步骤将所得组合物的氢化糖的内部脱水产物成形。 该方法特别可以获得稳定的异山梨醇组合物，其特征在于其某些稳定或不稳定物质的纯度和/或其含量。

公开(公告)号：US20040225162A1

公开(公告)日：2004-11-11

申请号：US10634687

申请日：2003-08-05

发明人： Hari Babu Sunkara ,  Hiep Quang Do

IPC分类号： C07C031/18

CPC分类号： C08G65/46

摘要： A process is described for reducing the discoloration of PO3G. The discolored polymer is contacted with adsorbent and separated therefrom, for instance, by filtration. The treated polytrimethylene, preferably, has an APHA color of less than about 50 and a molecular weight of about 250 to about 5000.

摘要翻译： 描述了一种减少PO3G变色的方法。 变色的聚合物与吸附剂接触并与其分离，例如通过过滤。 经处理的聚三亚甲基优选具有小于约50的APHA颜色和约250至约5000的分子量。

公开(公告)号：US20040152907A1

公开(公告)日：2004-08-05

申请号：US10712399

申请日：2003-11-14

申请人： Archer-Daniels-Midland Company

发明人： Kevin M. Moore ,  Alexandra J. Sanborn

IPC分类号： C07D307/02 ,  C07C033/02 ,  C07C031/18

CPC分类号： C07H1/00 ,  C07D493/04

摘要： A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. In some embodiments of the present invention, film evaporators are used in distillation and purification of the anhydrosugar alcohols. Anhydrosugar alcohols of very high purity are achieved in the practice of the present invention. In some embodiments of the present invention, very high purities of the anhydrosugar alcohols are achieved without the use of organic solvents.

摘要翻译： 提供了用于制备脱水葡萄糖醇的方法。 该方法包括在酸催化剂存在下加热糖醇或单一脱水葡萄糖醇原料，随后纯化脱水葡萄糖醇。 在本发明的一些实施方案中，薄膜蒸发器用于蒸馏和纯化脱水葡萄糖醇。 在本发明的实践中实现了非常高纯度的脱水葡萄糖醇。 在本发明的一些实施方案中，在不使用有机溶剂的情况下实现非常高纯度的脱水糖醇。

公开(公告)号：US20040082821A1

公开(公告)日：2004-04-29

申请号：US10473213

申请日：2003-09-29

发明人： Michael Koch ,  Steffen Maas ,  Wolfgang Jurgen Popel ,  Matthias Dernbach

IPC分类号： C07C031/18 ,  C07C029/14

CPC分类号： C07C29/141 ,  B01J21/063 ,  B01J21/066 ,  B01J23/72 ,  B01J35/023 ,  B01J35/10 ,  B01J37/0009 ,  B01J37/031 ,  C07C31/22

摘要： In a process for the catalytic hydrogenation of a carbonyl compound or a mixture of two or more carbonyl compounds in the presence of catalyst tablets which comprise an inorganic, TiO2-containing support and, as active component, copper or a mixture of copper with at least one metal selected from the group consisting of zinc, aluminum, cerium, nobel metals and metals of transition group VIII and whose copper surface area is not more than 10 m2/g, the diameter d and/or the height h of the tablets is less than 3 mm.

摘要翻译： 在催化剂片剂的催化剂片剂的催化氢化的催化氢化过程中，催化剂片剂包含无机TiO 2载体和作为活性成分的铜或至少铜的混合物 选自由锌，铝，铈，诺贝尔金属和过渡族VIII族金属组成的组中的一种金属，其铜表面积不超过10m 2 / g，直径d和/或高度h 片剂小于3毫米。

公开(公告)号：US20040077885A1

公开(公告)日：2004-04-22

申请号：US10274580

申请日：2002-10-21

发明人： Daniel Campos ,  Richard Edward Ernst

IPC分类号： C07D307/02 ,  C07C031/18

CPC分类号： C07D315/00 ,  C07C29/149 ,  C07C29/177 ,  Y02P20/584 ,  C07C31/207

摘要： A process for production of tetrahydrofuran, gamma butyrolactone, 1,4 butanediol and the like from a hydrogenatable precursor such as maleic acid, succinic acid, corresponding esters and their mixtures and the like in an aqueous solution in the presence of hydrogen using a noble metal catalyst, wherein a deactivated noble metal catalyst is regenerated by contacting the catalyst with a solvent, separating the solvent from the catalyst, and then reusing the regenerated catalyst in the process.

摘要翻译： 在氢气存在下，使用贵金属制备四氢呋喃，γ-丁内酯，1,4-丁二醇等从可氢化前体如马来酸，琥珀酸，相应的酯及其混合物等中制备的方法 催化剂，其中通过使催化剂与溶剂接触，使溶剂与催化剂分离，然后在该方法中重新使用再生催化剂来再生惰性金属催化剂。

公开(公告)号：US20030229235A1

公开(公告)日：2003-12-11

申请号：US10414605

申请日：2003-04-16

发明人： Kamlesh Kumar Bhatia

IPC分类号： C07D307/02 ,  C07C029/74 ,  C07C031/18

CPC分类号： C07D493/04

摘要： A process for recycling reaction byproducts in the manufacture of dianhydro sugar alcohols, such as isosorbide, from corresponding sugar alcohols.

摘要翻译： 在制备二氢糖醇（如异山梨醇）中从相应的糖醇中回收反应副产物的方法。

公开(公告)号：US20010001106A1

公开(公告)日：2001-05-10

申请号：US09725757

申请日：2000-11-30

发明人： Tomohiro Yoshinari ,  Fritz Schueckler ,  Norbert Poellinger ,  Shinji Maegata

IPC分类号： C07C031/18

CPC分类号： C07C31/26 ,  A61K9/2018 ,  A61K31/44 ,  C07C29/76

摘要： D-mannitol having a specific surface area of not less than about 1 m2/g is disclosed. The D-mannitol shows improved compressibility and is useful as an excipient.

公开(公告)号：US20040254407A1

公开(公告)日：2004-12-16

申请号：US10490450

申请日：2004-03-24

发明人： Satoru Mizutani ,  Koji Hisamura ,  Hirotaka Kinoshita

IPC分类号： C07C031/18 ,  C07C029/74

CPC分类号： C07C29/86 ,  C07C29/80 ,  C07C31/20 ,  C07C31/207

摘要： The present invention provides the following null1null to null3null, etc. null1null 1,3-Butylene glycol where, in a gas chromatographic analysis under a specific condition, the sum of area values of peaks appearing during the specific relative retention time to the area value of the peak of 1,3-butylene glycol is not more than 0.025%. null2null 1,3-Butylene glycol where, in a gas chromatographic analysis under a specific condition, the sum of area values of peaks of compounds having a hydroxyl group and an ether bond and having a molecular weight of 188 to the area value of the peak of 1,3-butylene glycol is not more than 0.025%. null3null 1,3-Butylene glycol where, in a gas chromatographic analysis under a specific condition, the sum of area values of peaks of 2-butoxy-6-methyl-4-tetrahydropyranol to the area value of the peak of 1,3-butylene glycol is not more than 0.025%.

摘要翻译： 本发明提供以下[1]〜[3]等。[1] 1,3-丁二醇，其中在特定条件下的气相色谱分析中，在特定相对保留期间出现峰的面积值之和 时间到1,3-丁二醇峰值的面积值不大于0.025％。 [2] 1,3-丁二醇，其中在特定条件下的气相色谱分析中，具有羟基和醚键的化合物的峰的面积值之和与分子量为188的面积值之和 1,3-丁二醇的峰值不大于0.025％。 [3] 1,3-丁二醇，其中在特定条件下的气相色谱分析中，2-丁氧基-6-甲基-4-四氢吡喃的峰面积值与峰的面积值之和为1， 3-丁二醇不大于0.025％。